Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real World Outcomes

Yellin, Jessica Izhakoff; Gaebler, Julia; Zhou, Frank F.; Niecko, Timothy; Novins, Olivia; Ockert, Amelia; Krzynowek, Darcy; Garoufalis, Matthew G.; Lee, Aliza M.; Frykberg, Robert G.

doi:10.2139/ssrn.3866544

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Regulating blood glucose levels and appropriate insulin therapy have shown high efficacy in wound closure (Veves et al, 2001). Other methods, such as revascularization (Liu et al, 2019), hyperbaric oxygen therapy (Raspovic et al, 2022), and granulocyte colony-stimulating factor (Yellin et al, 2022), have also been used. However, in most cases, wound dressings create an optimal environment for open wounds, leading to better and faster wound closure (Futrega et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

Jiang,

Zeng,

et al. 2024

Front. Bioeng. Biotechnol.

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Diabetic wounds are a significant subset of chronic wounds characterized by elevated levels of inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They are also associated with impaired angiogenesis, persistent infection, and a high likelihood of hospitalization, leading to a substantial economic burden for patients. In severe cases, amputation or even mortality may occur. Diabetic foot ulcers (DFUs) are a common complication of diabetes, with up to 25% of diabetic patients being at risk of developing foot ulcers over their lifetime, and more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit a structural similarity to the extracellular matrix (ECM), promoting the adhesion, growth, and migration of fibroblasts, thereby facilitating the formation of new skin tissue at the wound site. The composition and size of electrospun scaffolds can be easily adjusted, enabling controlled drug release through fiber structure modifications. The porous nature of these scaffolds facilitates gas exchange and the absorption of wound exudate. Furthermore, the fiber surface can be readily modified to impart specific functionalities, making electrospinning nanofiber scaffolds highly promising for the treatment of diabetic wounds. This article provides a concise overview of the healing process in normal wounds and the pathological mechanisms underlying diabetic wounds, including complications such as diabetic foot ulcers. It also explores the advantages of electrospinning nanofiber scaffolds in diabetic wound treatment. Additionally, it summarizes findings from various studies on the use of different types of nanofiber scaffolds for diabetic wounds and reviews methods of drug loading onto nanofiber scaffolds. These advancements broaden the horizon for effectively treating diabetic wounds.

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Section: Introductionmentioning

confidence: 99%

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

Jiang,

Zeng,

et al. 2024

Front. Bioeng. Biotechnol.

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The Diabetic Foot, Its Complications, Role of Technology in Evidence-Based Management

Dixon

Edmonds

2023

Chronic Wound Management

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Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

Frykberg

2021

Medicina

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Oxygen is a critical component of many biological processes and is essential for wound healing. Chronic wounds are typically characterized as being hypoxic in that the partial pressure of oxygen (pO2) in the center of the wound is often below a critical threshold necessary to fully support those enzymatic processes necessary for tissue repair. Providing supplemental oxygen can effectively raise pO2 levels to better optimize functioning of these essential enzymes. While hyperbaric oxygen therapy has been well studied in this regard, comparative clinical studies have fallen short of providing clear evidence in support of this modality for healing chronic diabetic foot ulcers (DFU). Topical oxygen therapy (TOT) has been in clinical use for over 50 years with encouraging pre-clinical and clinical studies that have shown improved healing rates when compared to standard care. Nonetheless, TOT has heretofore been discounted as an unproven wound healing modality without theoretical or clinical evidence to support its use. This review shall provide a brief summary of the role of oxygen in wound healing and, specifically, discuss the different types of topical oxygen devices and associated studies that have convincingly shown their efficacy in healing chronic DFUs. The time has come for topical oxygen therapy to be embraced as a proven adjunctive modality in this regard.

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Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real World Outcomes

Cited by 3 publications

References 27 publications

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

The Diabetic Foot, Its Complications, Role of Technology in Evidence-Based Management

Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

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