Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors

Kesler, Shelli R.; Janelsins, Michelle Christine; Koovakkattu, Della; Palesh, Oxana; Mustian, Karen M.; Morrow, Gary R.; Dhabhar, Firdaus S.

doi:10.1016/j.bbi.2012.05.017

Cited by 259 publications

(277 citation statements)

References 102 publications

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“…Prospective studies have revealed that both frontal and temporal cortex showed the most pronounced volume reductions [27,28]. A recent cross-sectional investigation provided evidence for hippocampal damage that was related to decreased verbal memory performance [29]. In line with the findings from the animal work reported above, diffusion tensor imaging (DTI) studies have found chemotherapy-related reductions of white matter integrity that correlated with cognitive performance [30].…”

Section: Manysupporting

confidence: 67%

Challenges in research on the neural basis of „chemobrain”

Kaiser

Dietrich

2014

Translational Neuroscience

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Cancer survivors treated with chemotherapy frequently complain about impairment of cognitive functions including attention and memory. While the contribution of factors like psychological distress, anxiety or fatigue to this "chemobrain" syndrome has been discussed, studies in rodents have demonstrated the toxicity of various chemotherapeutic substances to the adult central nervous system. In humans, structural brain imaging has revealed both reduced gray and white matter volume and decreased white matter integrity related to chemotherapeutic treatment. Studies of brain function have found alterations in brain activation patterns during different types of tasks. Nevertheless, further clinical research using prospective designs in larger samples is required to better understand the relationship between chemotherapy and cognitive deficits. Variables that need to be considered more systematically include drug dose, genetic variations, and psychological factors. Assessing both electroencephalographic and hemodynamic responses during tasks at different stages of the processing hierarchy and at di erent di culty levels should help in pinpointing the cortical processes a ected by chemotherapy.

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Section: Manysupporting

confidence: 67%

Challenges in research on the neural basis of „chemobrain”

Kaiser

Dietrich

2014

Translational Neuroscience

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“…These include reduced gray matter volumes of brain regions associated with the DMN, particularly the precuneus, cingulate, lateral parietal cortex, medial frontal gyrus, and hippocampus (10)(11)(12). Gray matter atrophy can significantly alter DMN connectivity (8).…”

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confidence: 99%

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Kesler

Wefel²,

Hosseini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

105

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Breast cancer (BC) chemotherapy is associated with cognitive changes including persistent deficits in some individuals. We tested the accuracy of default mode network (DMN) resting state functional connectivity patterns in discriminating chemotherapy treated (C+) from non–chemotherapy (C−) treated BC survivors and healthy controls (HC). We also examined the relationship between DMN connectivity patterns and cognitive function. Multivariate pattern analysis was used to classify 30 C+, 27 C−, and 24 HC, which showed significant accuracy for discriminating C+ from C− (91.23%, P < 0.0001) and C+ from HC (90.74%, P < 0.0001). The C− group did not differ significantly from HC (47.06%, P = 0.60). Lower subjective memory function was correlated ( P < 0.002) with greater hyperplane distance (distance from the linear decision function that optimally separates the groups). Disrupted DMN connectivity may help explain long-term cognitive difficulties following BC chemotherapy.

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“…Remarkably diminished left hippocampus size and worsened functioning of verbal memory were correlated with significantly increased level of IL-6 (interleukin 6) and TNF-α (tumour necrosis factor) in female patients diagnosed with breast cancer undergoing chemotherapy when compared to healthy women. The interaction between TNF-α and IL-6 which suggests that IL-6 may modulate the influence of TNF-α on hippocampus has also been found [14] .…”

Section: Heterogeneity Of the Phenomenon -Causesmentioning

confidence: 98%

“…Znacząco zmniejszona wielkość lewego hipokampa i gorsze funkcjonowanie pamięci werbalnej było skorelowane z istotnie podwyższonym poziomem IL-6 (interleukiny 6) i TNF-α (czynnikiem nekrozy nowotworów) u kobiet ze zdiagnozowanym nowotworem piersi poddawanych leczeniu chemioterapeutycznemu w porównaniu do osób zdrowych. Znaleziono również interakcję TNF-α i IL-6, która sugeruje, że IL-6 może modulować oddziaływanie TNF-α na hipokamp [14].…”

Section: Niejednorodność Zjawiska -Przyczynyunclassified

“…Generally, the biological factors, such as TNF-α, IL-6, BDNF play a significant role in creating and modifying cognitive deficits among patients with diagnosed cancer, mainly in case of women with breast cancer [14][15][16]. These compounds turned out to be crucial in development of cancer among the patient with multiple myeloma [29][30][31]39].…”

Section: Chemobrain and Multiple Myelomamentioning

confidence: 99%

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Review paper. Chemobrain in patients suffering from cancer based on the example of multiple myeloma

Bury

2017

Current Problems of Psychiatry

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Introduction: The incidence rate of cancers emphasizes the necessity to investigate not only patients' somatic ailments but also their psychosocial functioning as well as the need to raise the quality standards of cancer patients. The improvement of the quality of life is one of the major challenges of psycho-oncology, which is the science created in the interface of two disciplines: psychology and medicine.One of the important aspects of psycho-oncologists' activity is the minimization of negative side-effects related to treatment, such as changes in patients' cognitive functioning resulting from anti-cancer treatment.Objective: The aim of this work is to provide the reader with the knowledge concerning the phenomenon of chemobrain in a very special group of patients with hemato-oncologic tumour. Few researches related to this topic have confirmed the occurrence of cognitive deficits resulting from the cancer process, taken cytotoxic drugs, other forms of anti-cancer therapy and the activeness of biochemical compounds in patients with multiple myeloma.Methods: The author has done a literary review concerning the topic under study using the Google Scholar and EBSCO databases. The main part of this work consists of references to Polish and English research literature published after 2000. The review includes also classic works from the eighties and nineties of the 20th century.Results: The present work has been divided into several sections. The part devoted to explanation of the term chemobrain describes the evolution of its definition over the years. The second section -'Heterogeneity of the phenomenon -causes' -underlines the influence of biochemical etiological factors, such as the impact of the activity of proinflammatory cytokines on the cognitive state of the patients suffering from tumour. Next part -'Chemobrain and multiple myeloma' is devoted to the clinical characteristics of this cancer and to the descriptions of the selected methods of chemotherapy. The review of researches concerning the deteriorated cognitive functioning of patients with multiple myeloma in relation to the probable aetiology of this disease has been also presented.Conclusions: The review of Polish and English literature concerning the functioning of memory and attention processes in the patients suffering from multiple myeloma can serve as an inspiration for a search for objective biochemical factors conditioning the deterioration of cognitive processes of the patients undergoing anti-cancer treatment.

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Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors

Cited by 259 publications

References 102 publications

Challenges in research on the neural basis of „chemobrain”

Challenges in research on the neural basis of „chemobrain”

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Review paper. Chemobrain in patients suffering from cancer based on the example of multiple myeloma

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