Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder

Villarreal, Gerardo; Hamilton, Derek A.; Petropoulos, Helen; Driscoll, Ira; Rowland, Laura M.; Griego, Jaqueline A; Kodituwakku, Piyadasa; Hart, Blaine L.; Escalona, Rodrigo; Brooks, William M.

doi:10.1016/s0006-3223(02)01359-8

Cited by 321 publications

(212 citation statements)

References 35 publications

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“…Villarreal et al 2002. People given a drug that blocks the effects of stress hormones do not remember well the details of an upsetting story at a later time (Cahill et al 1994).…”

Section: Chapter 16mentioning

confidence: 99%

Efficient Learning for the Poor: Insights from the Frontier of Cognitive Neuroscience

Abadzi¹

2006

PsycEXTRA Dataset

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“…Villarreal et al 2002. People given a drug that blocks the effects of stress hormones do not remember well the details of an upsetting story at a later time (Cahill et al 1994).…”

Section: Chapter 16mentioning

confidence: 99%

Efficient Learning for the Poor: Insights from the Frontier of Cognitive Neuroscience

Abadzi¹

2006

PsycEXTRA Dataset

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“…Hippocampal volume is reduced in patients with longstanding depression (Campbell et al, 2004;Videbech and Ravnkilde, 2004) and severe, unremitting post-traumatic stress disorder (PTSD; Bremner et al, 1995Bremner et al, , 1997Gilbertson et al, 2002;Gurvits et al, 1996;Lindauer et al, 2004;Stein et al, 1997;Villarreal et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…In a number of cases, such trait factors indeed had a significant influence on hippocampal volume (eg, De Bellis et al, 2002;Fennema-Notestine et al, 2002;Gurvits et al, 1996;Lindauer et al, 2004;MacQueen et al, 2003;Rusch et al, 2001;Villarreal et al, 2002). While this approach cannot provide mechanistic information, it can 'refine' a diagnosis with the help of theoretically and operationally better defined entities.…”

Section: Introductionmentioning

confidence: 99%

Anxiety and Hippocampus Volume in the Rat

Kalisch

Schubert

Jacob

et al. 2005

Neuropsychopharmacol

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In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxietyrelated behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. Neuropsychopharmacology (2006) 31, 925-932.

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“…For example, smaller bilateral hippocampi in patients with schizophrenia have been found by a large number of research groups, [22][23][24][25][26][27] but not by others. [28][29][30][31] Similarly, several groups found smaller bilateral hippocampi in patients with PTSD, 32,33 whereas others were unable to find significantly smaller hippocampi in PTSD. [34][35][36] In MD, significantly smaller bilateral hippocampal volumes have been reported by some, 11,37,38 but not by others.…”

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confidence: 99%

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

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The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.

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Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder

Cited by 321 publications

References 35 publications

Efficient Learning for the Poor: Insights from the Frontier of Cognitive Neuroscience

Efficient Learning for the Poor: Insights from the Frontier of Cognitive Neuroscience

Anxiety and Hippocampus Volume in the Rat

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

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