Reduced high‐molecular‐weight adiponectin is an independent risk factor for cardiovascular lesions in hypercholesterolaemic patients

Wang, Wenqing; Xing, Wenjuan; Hf, Zhang; Ding, Mao; Shang, Lei; Wang, Xiaoming; Li, Rong

doi:10.1111/j.1365-2265.2012.04444.x

Cited by 10 publications

(8 citation statements)

References 34 publications

(51 reference statements)

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“…Data concerning the physiological role of LMW AN remains extremely rare, particularly in juvenile populations, and findings are inconsistent. LMW AN has been negatively correlated with WC, BMI and WHR in some studies [40][41][42] but this relationship is inconsistent in adults 20,37,43 and generally absent in younger age groups. 23,24 In relation to LMW AN and other CVD biomarkers, Baumann et al 13 examined AN in relation to blood pressure and reported that whilst total AN was not significantly different between hypertensive and normotensive patients, there was a shift in isoform distribution, with HMW AN being significantly lower and LMW AN being significantly higher, in hypertensives versus normotensives.…”

Section: Discussionmentioning

confidence: 96%

“…Studies of AN isoforms have mainly demonstrated that the HMW form is the most metabolically active, 4,16,17 compared with the MMW and LMW forms, and that HMW AN is a better marker of insulin resistance and CVD risk than total AN. [17][18][19] Recent research 20 suggests that individuals with low levels of HMW and MMW AN and concurrent hypercholesterolaemia are more susceptible to sequential CVD. Most of the research regarding the relationship between AN, obesity and cardiovascular (CV) risk comes from adult populations.…”

Section: Introductionmentioning

confidence: 99%

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Adiponectin multimers, body weight and markers of cardiovascular risk in adolescence: Northern Ireland Young Hearts Project

et al. 2013

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Prominent, BMI-independent associations between total and HMW AN, but not LMW AN, and CVD risk factors were already evident in this young population. This research in adolescents supports the contention that AN subfractions may have different biological actions. These associations in apparently healthy adolescents suggest an important role for AN and its subfractions in the pathogenesis of metabolic syndrome traits and indicate that the potential for total or HMW AN to act as early universal biomarkers of CV risk warrants further study.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Adiponectin multimers, body weight and markers of cardiovascular risk in adolescence: Northern Ireland Young Hearts Project

et al. 2013

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“…The HMW:TA ratio is a superior marker of insulin resistance compared to total and HMW adiponectin levels individually [ 18 ]. It is also an independent risk factor for coronary vascular disease (CVD) [ 19 ]. Previous studies have shown increased cardiovascular risk in HIV-infected patients, including those on HAART [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors

et al. 2014

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BackgroundAt the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease inhibitors (PI) and NRTIs). HAART is associated with the lipodystrophy syndrome, insulin resistance and reduced total adiponectin (TA) levels. The high molecular weight (HMW):TA ratio is a superior marker of insulin resistance. The aim of this study was to establish whether HMW:TA ratios are low in patients on PIs and whether they correlate with insulin resistance.MethodsThis was a cross-sectional study undertaken in an antiretroviral clinic at a tertiary hospital. The participants were 66 HIV-infected females: 22 were on regimen 2 (PI group), 22 on regimen 1 (non-PI) and 22 treatment naïve (TN), matched for BMI and age. Patients with a history of diabetes or impaired glucose tolerance were excluded. Serum adiponectin multimers were analysed using the AlpcoTM Adiponectin (Multimeric) enzyme immunoassay. Waist hip ratios (WHR), glucose and insulin levels were assessed, and HOMA-IR and QUICKI calculated. Data were analysed non-parametrically and multivariate analysis was performed.ResultsTA and HMW levels were lower in the treatment groups than in the TN group. HMW:TA was lower in the PI than in the non-PI and TN groups, and in the non-PI than in the TN groups. HMW:TA correlated negatively with waist, insulin and HOMA-IR, independently of BMI and duration of therapy. HOMA-IR and QUICKI did not differ among the groups.ConclusionHMW:TA is significantly decreased with HAART (particularly with PIs, but also with non-PIs) and may be a more sensitive marker of insulin resistance in these patients than conventional markers or HMW and total adiponectin individually.

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“…Elderly individuals and those with kidney disease were not included in the present study. Adipose tissue accumulation leading to the development of obesity that is accompanied by a prevailing proinflammatory state clearly leads to a decrease in both total adiponectin and HMW adiponectin levels [ 7 ]. Similarly, in diabetic patients participating in the present study, diabetes mellitus was accompanied by obesity and CRP levels were slightly raised as compared with metabolically healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…The association between individual lipoprotein particles and adiponectin levels may vary depending on the development of cardiovascular lesions; a decrease in adiponectin levels means a compensatory reaction. HMW adiponectin levels positively correlate with total cholesterol and HDL cholesterol levels [ 7 ]. The present study found a weak correlation between HMW adiponectin and ApoA1, particularly among healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients

Horáková

Azeem

Benešová

et al. 2015

International Journal of Endocrinology

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The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.

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Reduced high‐molecular‐weight adiponectin is an independent risk factor for cardiovascular lesions in hypercholesterolaemic patients

Abstract: These results suggest that reduced HMW isoform concentrations might be considered as an independent risk factor for cardiovascular complications in patients with HC.

Cited by 10 publications

References 34 publications

Adiponectin multimers, body weight and markers of cardiovascular risk in adolescence: Northern Ireland Young Hearts Project

Adiponectin multimers, body weight and markers of cardiovascular risk in adolescence: Northern Ireland Young Hearts Project

High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors

Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients

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