Reduced gut bacterial translocation in European sea bass (Dicentrarchus labrax) fed mannan oligosaccharides (MOS)

Torrecillas, Silvia; Makol, Alex; Benítez‐Santana, T.; Caballero, M. J.; Montero, Daniel; Sweetman, John; Izquierdo, Marisol

doi:10.1016/j.fsi.2010.12.020

Cited by 77 publications

(76 citation statements)

References 48 publications

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“…However, fold width was reduced in fish fed cMOS, which could be due to a reduced engrossment of the submucosa within the fold basis. Besides, the presence of thinner folds in fish fed cMOS may result in a higher absorptive surface by increasing the number of folds by intestinal section in agreement with previous studies in the same fish species with the first generation product [11] and in relation to the enhanced SGR found in the present study. Indeed, further morphometric studies are being conducted in order to corroborate this hypothesis.…”

Section: Discussionsupporting

confidence: 93%

Effects of dietary concentrated mannan oligosaccharides supplementation on growth, gut mucosal immune system and liver lipid metabolism of European sea bass (Dicentrarchus labrax) juveniles

Torrecillas

Montero

Caballero

et al. 2015

Fish & Shellfish Immunology

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Section: Discussionsupporting

confidence: 93%

Effects of dietary concentrated mannan oligosaccharides supplementation on growth, gut mucosal immune system and liver lipid metabolism of European sea bass (Dicentrarchus labrax) juveniles

Torrecillas

Montero

Caballero

et al. 2015

Fish & Shellfish Immunology

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“…The ability of orally-delivered immunostimulants to enhance innate immunity seems to be different in the gut, compared to other mucosal surfaces. This is illustrated by a recent study where mannan was orally administered to seabass and gut but not skin mucus innate immune functions were significantly modulated [122]. On the other hand, feeding ergosan or fermented Saccharomyces cerevisiae to rainbow trout enhances skin mucus innate immune parameters, indicating some connection between both compartments [123, 124].…”

Section: Exploiting Mucosal Immunity For Immunotherapymentioning

confidence: 99%

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

Gómez

Sunyer

Salinas

2013

Fish & Shellfish Immunology

580

348

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The field of mucosal immunology research has grown fast over the past few years, and our understanding on how mucosal surfaces respond to complex antigenic cocktails is expanding tremendously. With the advent of new molecular sequencing techniques, it is easier to understand how the immune system of vertebrates is, to a great extent, orchestrated by the complex microbial communities that live in symbiosis with their hosts. The commensal microbiota is now seen as the “extended self” by many scientists. Similarly, fish immunologist are devoting important research efforts to the field of mucosal immunity and commensals. Recent breakthroughs on our understanding of mucosal immune responses in teleost fish open up the potential of teleosts as animal research models for the study of human mucosal diseases. Additionally, this new knowledge places immunologists in a better position to specifically target the fish mucosal immune system while rationally designing mucosal vaccines and other immunotherapies. In this review, an updated view on how teleost skin, gills and gut immune cells and molecules, function in response to pathogens and commensals is provided. Finally, some of the future avenues that the field of fish mucosal immunity may follow in the next years are highlighted.

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“…In fish as in mammals, it has been shown that the mucus layer is continuously secreted and thereby washes away trapped particles. The main components of this mucus layer are secreted mucins (20,21). In mammals, each mucin can carry on the order of 100 different carbohydrate structures, which provides a vast array of potential binding sites for microbes (20).…”

mentioning

confidence: 99%

Aeromonas salmonicida Binds Differentially to Mucins Isolated from Skin and Intestinal Regions of Atlantic Salmon in an N -Acetylneuraminic Acid-Dependent Manner

et al. 2014

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b Aeromonas salmonicida subsp. salmonicida infection, also known as furunculosis disease, is associated with high morbidity and mortality in salmonid aquaculture. The first line of defense the pathogen encounters is the mucus layer, which is predominantly comprised of secreted mucins. Here we isolated and characterized mucins from the skin and intestinal tract of healthy Atlantic salmon and studied how A. salmonicida bound to them. The mucins from the skin, pyloric ceca, and proximal and distal intestine mainly consisted of mucins soluble in chaotropic agents. The mucin density and mucin glycan chain length from the skin were lower than were seen with mucin from the intestinal tract. A. salmonicida bound to the mucins isolated from the intestinal tract to a greater extent than to the skin mucins. The mucins from the intestinal regions had higher levels of sialylation than the skin mucins. Desialylating intestinal mucins decreased A. salmonicida binding, whereas desialylation of skin mucins resulted in complete loss of binding. In line with this, A. salmonicida also bound better to mammalian mucins with high levels of sialylation, and N-acetylneuraminic acid appeared to be the sialic acid whose presence was imperative for binding. Thus, sialylated structures are important for A. salmonicida binding, suggesting a pivotal role for sialylation in mucosal defense. The marked differences in sialylation as well as A. salmonicida binding between the skin and intestinal tract suggest interorgan differences in the host-pathogen interaction and in the mucin defense against A. salmonicida.

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Reduced gut bacterial translocation in European sea bass (Dicentrarchus labrax) fed mannan oligosaccharides (MOS)

Cited by 77 publications

References 48 publications

Effects of dietary concentrated mannan oligosaccharides supplementation on growth, gut mucosal immune system and liver lipid metabolism of European sea bass (Dicentrarchus labrax) juveniles

Effects of dietary concentrated mannan oligosaccharides supplementation on growth, gut mucosal immune system and liver lipid metabolism of European sea bass (Dicentrarchus labrax) juveniles

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

Aeromonas salmonicida Binds Differentially to Mucins Isolated from Skin and Intestinal Regions of Atlantic Salmon in an N -Acetylneuraminic Acid-Dependent Manner

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