Reduced graphene oxide-ZnO nanocomposite based electrochemical sensor for sensitive and selective monitoring of 8-hydroxy-2′-deoxyguanosine

Hao, Junxing; Wu, Kangbing; Wan, Chidan; Tang, Yong

doi:10.1016/j.talanta.2018.04.028

Cited by 41 publications

(13 citation statements)

References 37 publications

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“…It is commendable that nano-biosensors have been applied for the direct and one-step electrochemical detection of BRCA1. Since the discovery of graphene nanomaterial due to its unique electronic, optical, chemical, and mechanical properties, many scientists have been working on finding graphene-based DNA biosensors [28,29].…”

Section: Introductionmentioning

confidence: 99%

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Xia

Chen

et al. 2020

Electroanalysis

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A label‐free DNA biosensor based on three‐dimensional reduced graphene oxide (3D‐rGO) and polyaniline (PANI) nanofibers modified glassy carbon electrode (GCE) was successfully developed for supersensitive detection of breast cancer BRCA1. The results demonstrated that 3D‐rGO and PANI nanofibers had synergic effects for reducing the charge transfer resistance (Rct), meaning a huge enhancement in electrochemical activity of 3D‐rGO‐PANI/GCE. Probe DNA could be immobilized on 3D‐rGO‐PANI/GCE for special and sensitive recognition of target DNA (1.0×10−15–1.0×10−7 M) with a theoretical LOD of 3.01×10−16 M (3S/m). Furthermore, this proposed nano‐biosensor could directly detect BRCA1 in real blood samples.

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Section: Introductionmentioning

confidence: 99%

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Xia

Chen

et al. 2020

Electroanalysis

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“…The growth of electrocatalysts directly on conductive substrates such as graphene nanosheets, carbon nanofibres and nanotubes and Ni foam is an effective way to improve the capacitive performance and cycling stability of the electrode materials by enhancing the electrical conductivity . Of particular interest is graphene and its derivatives such as reduced graphene oxide (rGO) possessing high surface area, good mechanical and thermal stability and have been widely investigated for electrochemical applications , Compared to the numerous reports of Ni(OH) 2 nanostructures for supercapacitor applications, studies on their oxygen evolution activity are less .…”

Section: Introductionmentioning

confidence: 99%

Hybrid Films of Ni(OH)₂ Nanowall Networks on Reduced Graphene Oxide Prepared at a Liquid/Liquid Interface for Oxygen Evolution and Supercapacitor Applications

et al. 2019

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Free‐standing films of reduced graphene oxide (rGO) based Ni(OH)2 nanowall structures are generated at a liquid/liquid interface involving in situ reaction and self‐assembly. The nanowall network of Ni(OH)2 sheets anchored on rGO layers with 10–15 nm wall thickness and ordered voids of average size 100 nm can serve as excellent candidates for catalyzing electrochemical oxygen evolution reaction (OER) as they expose maximum edge sites of Ni(OH)2 and allow diffusion and penetration of electrolytes into voids enhancing the contact area of the electrolyte/electrocatalyst interface. The unique morphology of the hybrid films exhibited high electrochemical surface area and low charge transfer resistance. Accordingly, rGO−Ni(OH)2 hybrid films display excellent catalytic activity and high cycling stability in alkaline solutions giving a current density of 10 mA cm−2 at an overpotential of 378 mV with a Tafel slope of 56 mV dec−1. The hybrid films also exhibited a high specific and areal capacitance of 1402 Fg−1 and 98.12 mF cm−2 at a scan rate of 5 mVs−1. OER activity and capacitance of the hybrid rGO−Ni(OH)2 films are higher compared to that of bare Ni(OH)2 film and is attributed to the synergic effect between the rGO layer and the ordered interconnected nanowall Ni(OH)2 nanostructures. The primary advantage of these hybrid films is that they can be collected on the desired substrate for ready use as electrodes without the use of any external binders.

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“…Hao et al [26] have prepared a nanocomposite using reduced graphene oxide (rGO) and ZnO nanoparticles (ZnO@rGO) via an in situ reduction of graphene oxide (GO) with Zn powder and coated glassy carbon electrode (GCE) ( Figure 1). The ensuing system (ZnO@rGO/GCE), characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), gave significantly enhanced oxidation signals of o 8 dGuo, compared with unmodified GCE and GO-modified GCE (GO/GCE), as verified by cyclic voltammetry (CV).…”

Section: Development Of New Electrodes Electrodes Coated With Reducedmentioning

confidence: 99%

mentioning

confidence: 99%

Analytical and Structural Studies for the Investigation of Oxidative Stress in Guanine Oligonucleotides

Ferenc

Váradi

Kupihár

et al. 2020

IJMS

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DNA damage plays a decisive role in epigenetic effects. The detection and analysis of DNA damages, like the most common change of guanine (G) to 8-oxo-7,8-dihydroguanine (OG), is a key factor in cancer research. It is especially true for G quadruplex structure (GQ), which is one of the best-known examples of a non-canonical DNA arrangement. In the present work, we provided an overview on analytical methods in connection with the detection of OG in oligonucleotides with GQ-forming capacity. Focusing on the last five years, novel electrochemical tools, like dedicated electrodes, were overviewed, as well as different optical methods (fluorometric assays, resonance light scattering or UV radiation) along with hyphenated detection and structural analysis methods (CD, NMR, melting temperature analysis and nanopore detection) were also applied for OG detection. Additionally, GQ-related computational simulations were also summarized. All these results emphasize that OG detection and the analysis of the effect of its presence in higher ordered structures like GQ is still a state-of-the-art research line with continuously increasing interest.

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Reduced graphene oxide-ZnO nanocomposite based electrochemical sensor for sensitive and selective monitoring of 8-hydroxy-2′-deoxyguanosine

Cited by 41 publications

References 37 publications

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Hybrid Films of Ni(OH)₂ Nanowall Networks on Reduced Graphene Oxide Prepared at a Liquid/Liquid Interface for Oxygen Evolution and Supercapacitor Applications

Analytical and Structural Studies for the Investigation of Oxidative Stress in Guanine Oligonucleotides

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Reduced graphene oxide-ZnO nanocomposite based electrochemical sensor for sensitive and selective monitoring of 8-hydroxy-2′-deoxyguanosine

Cited by 41 publications

References 37 publications

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Hybrid Films of Ni(OH)2 Nanowall Networks on Reduced Graphene Oxide Prepared at a Liquid/Liquid Interface for Oxygen Evolution and Supercapacitor Applications

Analytical and Structural Studies for the Investigation of Oxidative Stress in Guanine Oligonucleotides

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Hybrid Films of Ni(OH)₂ Nanowall Networks on Reduced Graphene Oxide Prepared at a Liquid/Liquid Interface for Oxygen Evolution and Supercapacitor Applications