REDUCED GENE FLOW AT PERICENTROMERIC LOCI IN A HYBRID ZONE INVOLVING CHROMOSOMAL RACES OF THE HOUSE MOUSE<i>MUS MUSCULUS DOMESTICUS</i>

Franchini, Paolo; Colangelo, Paolo; Solano, Emanuela; Capanna, Ernesto; Verheyen, Erik; Castiglia, Riccardo

doi:10.1111/j.1558-5646.2010.00964.x

Cited by 42 publications

(64 citation statements)

References 64 publications

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“…Results for this analysis of Italian mice with our set of loci (F ST ¼ 0.404; 95% confidence interval (CI): 0.308-0.487) are clearly similar to those obtained by Panithanarak et al (2004) and confirm that the degree of differentiation observed for the Madeiran metacentric mice is not because of some property of the particular microsatellites used in this study. This is further supported by the observed degree of differentiation between localities in Portugal (F ST ¼ 0.287; 95% CI: 0.249-0.326), Scotland (F ST ¼ 0.225; 95% CI: 0.158-0.301) and Spain (F ST ¼ 0.149; 95% CI: 0.106-0.189), which is in the same range as previous studies (Dallas et al, 1995(Dallas et al, , 1998Panithanarak et al, 2004;Franchini et al, 2008Franchini et al, , 2010.…”

Section: Relationship Of Madeiran Metacentric Mice With Those Of Elsesupporting

confidence: 78%

“…Previous studies in house mice involving chromosomally less divergent races typically show higher levels of genetic differentiation at microsatellite loci (F ST ¼ 0.39, 13 microsatellite loci (Panithanarak et al, 2004); F ST ¼ 0.187, 8 microsatellite loci (Franchini et al, 2008); F ST ¼ 0.133, 12 microsatellite loci (Franchini et al, 2010)). More pronounced differentiation has also been recorded in a study involving metacentric and standard karyotype (all-acrocentric) mice (F ST ¼ 0.29; eight microsatellite loci (Dallas et al, 1998)), as well as between standard karyotype mice, even in localities only 300 m distant from one another (F ST ¼ 0.18; six microsatellite loci (Dallas et al, 1995)).…”

Section: Relationship Of Madeiran Metacentric Mice With Those Of Elsementioning

confidence: 99%

“…Considering 179 mice from 36 localities in six geographic regions (Table 1), 331 alleles were found for the 21 microsatellite loci. The mean number of alleles per locus varied between localities, with a range of 1.2-4.7 (overall mean ¼ 3.5; (Dallas et al, 1998;Panithanarak et al, 2004;Franchini et al, 2008Franchini et al, , 2010.…”

Section: Microsatellite Variationmentioning

confidence: 99%

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Origin of the chromosomal radiation of Madeiran house mice: a microsatellite analysis of metacentric chromosomes

et al. 2012

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Chromosome races of Mus musculus domesticus are characterised by particular sets of metacentric chromosomes formed by Robertsonian fusions and whole-arm reciprocal translocations. The Atlantic island of Madeira is inhabited by six chromosome races of house mice with 6-9 pairs of metacentric chromosomes. Three of these races are characterised by the metacentric 3.8 also found elsewhere in the distribution of M. m. domesticus, including Denmark and Spain. We investigated the possibility that metacentric 3.8 was introduced to Madeira during the initial colonisation, as this could have 'seeded' the cascade of chromosomal mutation that is the basis of the extraordinary chromosomal radiation observed on the island. Variation at 24 microsatellite loci mapping to three different chromosomal regions (proximal, interstitial and distal) of mouse chromosomes 3 and 8 was investigated in 179 mice from Madeira, Denmark, Portugal, Spain, Italy and Scotland. Analyses of microsatellite loci closely linked to the centromeres of these chromosomes ('proximal loci') do not support a common evolutionary origin of metacentric 3.8 among Madeiran, Danish and Spanish mouse populations. Our results suggest that Madeiran mice are genetically more similar to standard karyotype mice from Portugal than to metacentric mice from elsewhere. There is expected to be an interruption to gene flow between hybridising metacentric races on Madeira, particularly in the chromosomal regions close to the rearrangement breakpoints. Consistent with this, relating to differentiation involving chromosomes 3 and 8 on Madeira, we found greater genetic structure among races for proximal than interstitial or distal loci.

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Section: Relationship Of Madeiran Metacentric Mice With Those Of Elsesupporting

confidence: 78%

Section: Relationship Of Madeiran Metacentric Mice With Those Of Elsementioning

confidence: 99%

Section: Microsatellite Variationmentioning

confidence: 99%

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Origin of the chromosomal radiation of Madeiran house mice: a microsatellite analysis of metacentric chromosomes

et al. 2012

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“…Thus, a differential effect on gene flow of hybrid breakdown vs reduced proximal recombination is expected. This suggests that (i) both recombination reduction and hybrid unfitness act synergistically to modify the gene flow landscape between chromosomal races of the house mouse as previously stated (Panithanarak et al, 2004;Franchini et al, 2010;Gimenez et al, 2013), and (ii) the effect of hybrid unfitness is expected to increase with the degree and type of heterozygosity. Combining simulation approaches with analyses, using high resolution genomic markers in wild populations, will undoubtedly assist in teasing apart the respective contribution of both factors, and further refine the expected patterns of divergence related to Rb fusions.…”

Section: Effect Of Rb Heterozygosity On Gene Flowmentioning

confidence: 79%

“…However, several studies have addressed this question by measuring the level of divergence of mapped microsatellite markers between chromosomally differentiated house mice. In all cases, centromeric loci exhibited higher differentiation levels than distal ones, regardless of the type of meiotic heterozygosity of the hybrids, that is, complex chains or rings (Panithanarak et al, 2004;Förster et al, 2013;Gimenez et al, 2013 ) or trivalents (Franchini et al, 2010). Previous studies have indicated that recombination suppression extended up to 15-20 cM from the centromere depending on the chromosomes involved in the Rb fusion and the genetic background (Davisson and Akeson, 1993;Gimenez et al, 2013;Capilla et al, 2014).…”

Section: Effect Of Rb Heterozygosity On Gene Flowmentioning

confidence: 99%

Reduced recombination patterns in Robertsonian hybrids between chromosomal races of the house mouse: chiasma analyses

2014

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The recombination suppression models of chromosomal speciation posit that chromosomal rearrangements act as partial barriers to gene flow allowing these regions to accumulate genetic incompatibilities, thus contributing to the divergence of populations. Empirical and theoretical studies exploring the requirements of these models have mostly focused on the role of inversions. Here, the recombination landscape of heterozygosity for Robertsonian (Rb) fusions is investigated in the house mouse. Laboratory-bred F1 males and females between highly differentiated races from Tunisia (Rb: 2n ¼ 22, Standard, St: 2n ¼ 40) were produced in which all Rb fusions are present as trivalents in meiosis. Recombination patterns were determined by the analysis of chiasmata and compared with previous data on the Tunisian parental mice. A comparative analysis was performed on wild-caught male mice spanning the hybrid zone between two Italian races (2n ¼ 40, 2n ¼ 22). The results showed that the chiasma characteristics of both male and female Tunisian F1 and Italian hybrids clearly differed from those of Rb and St mice. Not only was the mean chiasma number (CN) intermediate between those of the parental mice in both geographic samples, but the distribution of chiasmata along the chromosomal arms of the F1 showed a distinct mosaic pattern. In short, the proximal region in the F1 exhibited a reduced CN similar to that observed in homozygous Rb, whereas distal regions more closely matched those in St mice. These results suggest that Rb rearrangements (homozygous or heterozygous) reduce recombination in the proximal regions of the chromosomes supporting their potential role in recombination-mediated speciation models.

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Role of Chromosomal Reorganisations in the Human–Chimpanzee Speciation

Farré

Ruiz‐Herrera

2014

Encyclopedia of Life Sciences

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The elucidation of how recombination is shaping the genomic architecture of organisms and, more in particular, how this affects the speciation process has been a long‐standing question in evolutionary biology. Large‐scale genomic changes such as inversions, translocations, fusions and fissions contribute to the reshuffling of genomes, providing new chromosomal forms on which natural selection can work. Despite large efforts employed in the last decade, few empirical data are available on the mechanisms by which genome reshuffling contribute to the formation of new species. Here, the authors discuss on the models of chromosomal evolution and the contribution of chromosomal reorganisations in mammalian chromosome evolution, and more specifically, during the human–chimpanzee speciation event. Key Concepts: The evolutionary process by which new biological species arise (speciation) is a complex process that requires the understanding of many mechanisms such as reproductive isolation, patterns of species diversity, together with the genetic basis underlying the process. Understanding the mechanisms by which reproductive isolation (breakdown of gene flow between two populations) is achieved, is fundamental for speciation. Genetic speciation makes references to the group of genes that are involved in maintaining reproductive isolation between species. Chromosomal reorganisations may contribute to speciation due to the underdominant fitness effects associated with meiotic abnormalities when occurring in heterozygotes. Chromosome rearrangements, such as inversions, can suppress recombination thus contributing to a reduction of gene flow across genomic regions and the accumulation of genetic incompatibilities.

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REDUCED GENE FLOW AT PERICENTROMERIC LOCI IN A HYBRID ZONE INVOLVING CHROMOSOMAL RACES OF THE HOUSE MOUSEMUS MUSCULUS DOMESTICUS

Cited by 42 publications

References 64 publications

Origin of the chromosomal radiation of Madeiran house mice: a microsatellite analysis of metacentric chromosomes

Origin of the chromosomal radiation of Madeiran house mice: a microsatellite analysis of metacentric chromosomes

Reduced recombination patterns in Robertsonian hybrids between chromosomal races of the house mouse: chiasma analyses

Role of Chromosomal Reorganisations in the Human–Chimpanzee Speciation

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