“…Ophn1 encodes for a Rho GTPase activating protein (RhoGAP) which negatively regulates Rac, RhoA and Cdc42 (Billuart et al, 1998;Fauchereau et al, 2003;Khelfaoui et al, 2007). Ophn1 is expressed in several brain regions, including the cerebral cortex and the hippocampus, where it contributes to synapse maturation and plasticity (Govek et al, 2004;Khelfaoui et al, 2007;Powell et al, 2012;Powell et al, 2014). Ophn1 knock-out (KO) mice represent an excellent model of Ophn1 mutations in humans (Khelfaoui et al, 2007).…”