Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study

Ng, Kwun Kei; Lo, June C.; Lim, Joseph; Chee, Michael W.L.; Zhou, Juan

doi:10.1016/j.neuroimage.2016.03.029

Cited by 195 publications

(183 citation statements)

References 96 publications

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“…We have recently shown that increased coupling of these networks, as predicted by the DECHA is associated with reduced fluid intelligence and increased reliance on semantic or crystalized knowledge in older adulthood [126]. Recent evidence both from cross-sectional [96] and longitudinal [127] investigations provide support for this hypothesis and provide further evidence that these changes in network interactivity can predict individual differences in cognitive functioning. Taken together these network-based accounts of functional brain aging point to network neuroscience as an important new frontier in neurocognitive aging research.…”

Section: Changes In Functional Brain Networkmentioning

confidence: 78%

Structure and function of the aging brain

Spreng¹,

Turner²

2018

Preprint

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In this opening section of the Aging Brain we set the stage for the contributions that follow by providing a broad overview of the latest advances in our understanding of how the brain changes, both structurally and functionally, across the adult lifespan. We leave domain-specific aspects of brain aging to the subsequent chapters, where contributors will provide more targeted accounts of brain change germane to their particular focus on the aging brain. Here we review the extant, and rapidly expanding literature to provide a brief overview and introduction to structural and functional change that occur with typical brain aging. We begin the chapter by looking back, to review some of the early discoveries about how the brain changes across the adult lifespan. We close the chapter by looking forward, towards new discoveries that challenge our core assumptions about the inevitability or irreversibility of age-related brain changes. These sections serve as bookends for the core of the chapter where we review the latest research advances that continue to uncover the mysteries of the aging brain. Spreng, R.N., Turner, G.R. (2019, forthcoming) Structure and function of the aging brain. In G Samanez-Larkin (Ed.) The aging brain. Washington DC: American Psychological Association.

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Section: Changes In Functional Brain Networkmentioning

confidence: 78%

Structure and function of the aging brain

Spreng¹,

Turner²

2018

Preprint

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“…The current results partially support this hypothesis. The nature of the coupling and its association with task performance or cognitive ability is yet to be resolved as only a handful of studies have directly tested these issues to date (e.g., Ng et al, 2016; Rieck et al, 2017; Sambataro et al, 2010; Spreng et al, 2010; Spreng et al, 2014; Spreng et al, 2017). In the current study the coupled modulation was such that as modulation to difficulty in the positive modulation regions increased, there was lesser down-modulation of these deactivated regions.…”

Section: Discussionmentioning

confidence: 99%

Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance

Kennedy

Boylan

Rieck

et al. 2017

Neurobiology of Aging

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Alteration of dynamic range of modulation to cognitive difficulty has been proposed as a salient predictor of cognitive aging. Here we examine in 171 adults (aged 20–94 years) the effects of age on dynamic modulation of BOLD activation to difficulty in parametrically increasing working memory load (0-,2-,3-,4-back conditions). First, we examined parametric increases and decreases in activation to increasing WM load (positive modulation effect and negative modulation effect). Second, we examined the effect of age on modulation to difficulty (WM load) to identify regions that differed with age as difficulty increased (age-related positive and negative modulation effects). Weakened modulation to difficulty with age was found in both the positive-modulation (middle frontal, superior/inferior parietal) and negative-modulation effect (deactivated) regions (insula, cingulate, medial superior frontal, fusiform, and parahippocampal gyri, hippocampus, and lateral occipital cortex). Age-related alterations to positive modulation emerged later in the lifespan than negative modulation. Further, these effects were significantly coupled in that greater up-modulation was associated with lesser down-modulation. Importantly, greater frontal-parietal up-modulation to difficulty and greater down-modulation of deactivated regions was associated with better task accuracy and up-modulation with better working memory span measured outside the scanner. These findings suggest that greater dynamic range of modulation of activation to cognitive challenge is in service of current task performance, as well as generalizing to cognitive ability beyond the scanner task, lending support to its utility as a marker of successful cognitive aging.

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“…Lastly, our mediation and correlation analyses were based on cross-sectional data. Future longitudinal or lesion studies are needed to investigate the temporal dynamics or the possible causal relationships between CC degeneration, inter-hemispheric functional disconnections, and cognitive performance in disease progression67.…”

Section: Discussionmentioning

confidence: 99%

“…Task-free fMRI data preprocessing was performed using Data Processing & Analysis of Brain Imaging (DPABI 1.2)77 based on statistical parametric mapping (SPM8, http://www.fil.ion.ucl.ac.uk/spm), following our previous approaches677879 (Supplementary Methods for details).…”

Section: Methodsmentioning

confidence: 99%

Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI

Qiu

Liu

Hilal

et al. 2016

Sci Rep

Self Cite

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Evidences suggested that both corpus callosum (CC) degeneration and alternations of homotopic inter-hemispheric functional connectivity (FC) are present in Alzheimer’s disease (AD). However, the associations between region-specific CC degeneration and homotopic inter-hemispheric FC and their relationships with memory deficits in AD remain uncharacterized. We hypothesized that selective CC degeneration is associated with memory impairment in AD and amnestic mild cognitive impairment (aMCI), which is mediated by homotopic inter-hemispheric functional dysconnectivity. Using structural magnetic resonance imaging (MRI) and task-free functional MRI, we assessed the CC volume and inter-hemispheric FC in 66 healthy controls, 41 aMCI and 41 AD. As expected, AD had CC degeneration and attenuated inter-hemispheric homotopic FC. Nevertheless, aMCI had relatively less severe CC degeneration (mainly in mid-anterior, central, and mid-posterior) and no reduction in inter-hemispheric homotopic FC. The degeneration of each CC sub-region was associated with specific inter-hemispheric homotopic functional disconnections in AD and aMCI. More importantly, impairment of inter-hemispheric homotopic FC partially mediated the association between CC (particularly the central and posterior parts) degeneration and memory deficit. Notably, these results remained after controlling for hippocampal volume. Our findings shed light on how CC degeneration and the related inter-hemispheric FC impact memory impairment in early stage of AD.

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Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study

Cited by 195 publications

References 96 publications

Structure and function of the aging brain

Structure and function of the aging brain

Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance

Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI

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