Reduced functional connectivity in visual evoked potentials in children with autism spectrum disorder

Isler, Joseph R.; Martien, Katherine M.; Grieve, Philip G.; Stark, Raymond I.; Herbert, Martha R.

doi:10.1016/j.clinph.2010.05.004

Cited by 92 publications

(91 citation statements)

References 48 publications

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“…The current data clearly suggest that the main deficit in ASD is in the 60 -120 Hz frequency band. Finally, we found only limited evidence for increased high-frequency activity in the ASD group as previously reported (Brown et al, 2005;Isler et al, 2010;Stroganova et al, 2012) as elevated gamma-band activity was limited to an upregulation of 25-60 Hz activity over frontocentral sensors.…”

Section: Discussionmentioning

confidence: 51%

“…In the auditory domain, reduced entrainment to auditory stimulation at 40 Hz in participants with ASD (Wilson et al, 2007) as well as their firstdegree relatives (Rojas et al, 2011) has been demonstrated. In contrast, during visual perception there is evidence for both hyperactivity and hypoactivity of gamma-band oscillations (Grice et al, 2001;Brown et al, 2005;Milne et al, 2009;Isler et al, 2010;Stroganova et al, 2012), raising the question of the link between high-frequency oscillations and perceptual dysfunctions in the disorder.…”

Section: Introductionmentioning

confidence: 84%

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Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Sun

Grützner²,

Bölte³

et al. 2012

Journal of Neuroscience

138

134

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Current theories of the pathophysiology of autism spectrum disorders (ASD) have focused on abnormal temporal coordination of neural activity in cortical circuits as a core impairment of the disorder. In the current study, we examined the possibility that gamma-band activity may be crucially involved in aberrant brain functioning in ASD. Magneto-encephalographic (MEG) data were recorded from 13 adult human participants with ASD and 16 controls during the presentation of Mooney faces. MEG data were analyzed in the 25-150 Hz frequency range and a beamforming approach was used to identify the sources of spectral power. Participants with ASD showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces, while responses to inverted stimuli were in the normal range. Impaired perceptual organization in the ASD group was accompanied by a reduction in both the amplitude and phase locking of gamma-band activity. A beamforming approach identified distinct networks during perceptual organization in controls and participants with ASD. In controls, perceptual organization of Mooney faces involved increased 60 -120 Hz activity in a frontoparietal network, while in the ASD group stronger activation was found in visual regions. These findings highlight the contribution of impaired gamma-band activity toward complex visual processing in ASD, suggesting atypical modulation of high-frequency power in frontoposterior networks.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 84%

Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Sun

Grützner²,

Bölte³

et al. 2012

Journal of Neuroscience

138

134

View full text Add to dashboard Cite

show abstract

“…As in the imaging reports, the resulting evidence is conflicting and inconsistent. Twenty-one studies in the last decade have been published; 11 evaluated resting state (Murias et al 2007;Coben et al 2008;Barttfeld et al 2011;Bosl et al 2011;Duffy and Als 2012;Mathewson et al 2012;Sheikhani et al 2012;Leveille and Hannagan 2013;Peters et al 2013;Machado et al 2015), eight were task related (Isler et al 2010;Lazarev et al 2010;Catarino et al 2013;Garcia Dominguez et al 2013;Carson et al 2014;Orekhova et al 2014;Righi et al 2014;Lazarev et al 2015;Machado et al 2015); one obtained during non-rapid eye movement (NREM) sleep (Lazar et al 2010) and one obtained during rapid eye movement (REM) sleep (Leveille et al 2010). It is not possible to directly compare these studies as the acquisition paradigm, the age of the subjects, Figure 3.…”

Section: Aberrant Connectivity In Autismmentioning

confidence: 99%

Epilepsy and Autism

Buckley

Holmes

2016

Cold Spring Harb Perspect Med

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Epilepsy and autistic spectrum disorder frequently coexist in the same individual. Electroencephalogram (EEG) epileptiform activity is also present at a substantially higher rate in children with autism than normally developing children. As with epilepsy, there are a multitude of genetic and environmental factors that can result in autistic spectrum disorder. There is growing consensus from both animal and clinical studies that autism is a disorder of aberrant connectivity. As measured with functional magnetic resonance imaging (MRI) and EEG, the brain in autistic spectrum disorder may be under-or overconnected or have a mixture of over-and underconnectivity. In the case of comorbid epilepsy and autism, an imbalance of the excitatory/inhibitory (E/I) ratio in selected regions of the brain may drive overconnectivity. Understanding the mechanism by which altered connectivity in individuals with comorbid epilepsy and autistic spectrum disorder results in the behaviors specific to the autistic spectrum disorder remains a challenge.

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“…Martini et al, 2012). Phase consistency across trials (not across brain areas) can also be measured via phase coherence indices that have been variously termed as Inter-Trial Coherence (Port et al, 2007), Inter-Trial Phase Coherence and/or Phase Synchrony (Isler et al, 2010). While these measures are a significant improvement over mere power measures, giving insight into presence or absence of systematic rhythms across repetitions (trials), veridical phase estimates in gamma frequency, especially in high gamma, are hard to achieve due to the large spread of the respective frequency bands (e.g.…”

Section: Feature Integration and Gamma Band Activity (Gba)mentioning

confidence: 99%

Brain oscillations and connectivity in autism spectrum disorders (ASD): new approaches to methodology, measurement and modelling

Kessler

Seymour

Rippon

2016

Neuroscience & Biobehavioral Reviews

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Please cite this article as: Kessler, K., Seymour, R.A., Rippon, G., Brain oscillations and connectivity in autism spectrum disorders (ASD): new approaches to methodology, measurement and modelling.Neuroscience and Biobehavioral Reviews http://dx.doi.org/10. 1016/j.neubiorev.2016.10.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Abstract:Although atypical social behaviour remains a key characterisation of ASD, the presence of sensory and perceptual abnormalities has been given a more central role in recent classification changes. An understanding of the origins of such aberrations could thus prove a fruitful focus for ASD research. Early neurocognitive models of ASD suggested that the study of high frequency activity in the brain as a measure of cortical connectivity might provide the key to understanding the neural correlates of sensory and perceptual deviations in ASD. As our review shows, the findings from subsequent research have been inconsistent, with a lack of agreement about the nature of any high frequency disturbances in ASD brains.Based on the application of new techniques using more sophisticated measures of brain synchronisation, direction of information flow, and invoking the coupling between high and low frequency bands, we propose a framework which could reconcile apparently conflicting findings in this area and would be consistent both with emerging neurocognitive models of autism and with the heterogeneity of the condition.

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Reduced functional connectivity in visual evoked potentials in children with autism spectrum disorder

Cited by 92 publications

References 48 publications

Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Epilepsy and Autism

Brain oscillations and connectivity in autism spectrum disorders (ASD): new approaches to methodology, measurement and modelling

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