Reduced frequency of melanoma in 72,739 patients with psoriasis: A retrospective study

Methotrexate treatment and risk for cutaneous malignant melanoma: a retrospective comparative registry-based cohort study

“…An Italian retrospective study compared a group of nondermatology patients consisting of patients needing vascular surgery and patients with psoriasis. The study demonstrated that patients with psoriasis had a significantly lower probability of having melanoma . A retrospective nationwide Danish study demonstrated a modestly increased risk of melanoma and NMSC in patients with mild psoriasis, whereas patients with severe psoriasis and PsoA had increased risk of NMSC but not melanoma …”

“…The study demonstrated that patients with psoriasis had a significantly lower probability of having melanoma. 20 A retrospective nationwide Danish study demonstrated a modestly increased risk of melanoma and NMSC in patients with mild psoriasis, whereas patients with severe psoriasis and PsoA had increased risk of NMSC but not melanoma. 21 Interestingly, a publication investigating a melanoma in vitro model suggested that MTX upregulates Fas/FasL and enhances melanoma apoptosis, which might suggest an antineoplastic effect.…”

The Risk of Cancer in Patients With Psoriasis

“…Chen et al 6 found an increased risk for melanoma in Taiwanese patients with psoriasis compared with patients without psoriasis (HR, 3.10; 95% CI, 1.24-7.71). A more recent study 27 found that patients with psoriasis had a lower probability of developing melanoma when compared with a group of nondermatological patients. With respect to pancreatic cancer, a standardized incidence ratio (SIR) of 1.46 (95% CI, 1.10-1.95) has been previously reported, which is somewhat similar to our results (HR, 1.25; 95% CI, 1.04-1.51).…”

Skin cancer in patients with psoriasis

“…While the risk of NMSC [SIR 5.31 (2.63–10.71)] in the same meta‐analysis was markedly higher than in our study, it is important to note that the majority of studies in the aforementioned meta‐analysis included cohorts of patients treated with PUVA or cyclosporine which likely explains the markedly higher risk compared with our results. On the other hand, a very recent study of 72 739 Italian patients with psoriasis, and 25 956 control subjects admitted for vascular surgery, found a significantly decreased risk of melanoma in patients with psoriasis [relative risk 0.40 (0.31–0.51)] . One very recent study examined the association between self‐reported cancers and psoriasis .…”

“…7 While a recent large-scale Italian study found a significantly decreased risk of melanoma in patients with psoriasis, previous studies on the risk of melanoma and NMSC in patients with psoriasis have yielded opposing results. 8,9 We therefore investigated the risk of melanoma and NMSC, respectively, in a nationwide cohort of the Danish population.…”