Reduced, Free and Total Fractions of Homocysteine and Other Thiol Compounds in Plasma from Patients with Renal Failure

Hultberg, Björn; Andersson, Anders; Arnadottir, Margret

doi:10.1159/000188545

Cited by 74 publications

(35 citation statements)

References 15 publications

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“…The difference in patterns observed between the older and the younger groups was not attributable to the higher mortality in participants with high cholesterol at baseline (data not shown). Other factors, e.g., a decline in renal function, could be responsible for the increase in tCys in this older age group (23 ). This is reflected in the strong association between tCys and creatinine (Table 4) and in the high creatinine values in the older age groups compared with the younger groups ( Table 2).…”

Section: Discussionmentioning

confidence: 90%

Predictors of Change in Plasma Total Cysteine: Longitudinal Findings from the Hordaland Homocysteine Study

et al. 2003

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Section: Discussionmentioning

confidence: 90%

Predictors of Change in Plasma Total Cysteine: Longitudinal Findings from the Hordaland Homocysteine Study

et al. 2003

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“…The associated increase in serum creatinine (Table 3) suggests that elevation of both tCys and tHcy is due to an impaired renal function. 28 Renal failure has consistently been shown to cause increased levels of both tHcy and tCys, 29 and it is associated with high cardiovascular mortality and morbidity. 30 Our finding of increased risk of cardiovascular disease and elevated serum creatinine in subjects with the combination of high tCys and tHcy (Table 3) are in accordance with these published data.…”

Section: Discussionmentioning

confidence: 99%

Plasma Total Cysteine as a Risk Factor for Vascular Disease

et al. 2001

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Background-Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular disease. Although cysteine is structurally similar and metabolically linked to tHcy, its relation to the risk of cardiovascular disease has received little attention. We studied the relation between plasma total cysteine (tCys) levels and the risk of vascular disease in the coronary, cerebral, and peripheral vessels. Methods and Results-This case-control study included 750 patients with vascular disease and 800 age-and sex-matched control subjects recruited from 19 centers in 9 European countries. Conventional risk factors for cardiovascular disease were recorded. In addition, plasma levels of tCys, tHcy, folate, B 6 , B 12 , and creatinine were measured. Overall, a U-shaped relationship was observed between tCys and risk of vascular disease. With the middle range of 250 to 275 mol/L tCys used as the reference category, the adjusted risk of vascular disease at low (Յ225 mol/L) tCys levels was 2.1 (95% CI 1.2 to 3.6), and the risk at high (Ͼ300 mol/L) tCys levels was 1.6 (95% CI 1.1 to 2.3). Different shapes of the dose-response relationship were seen for the 3 vascular disease categories. The relation with peripheral vascular and cerebrovascular disease was U-shaped, whereas a weak positive relation was observed with coronary heart disease. Conclusions-Our data show a significant U-shaped relationship between tCys and cardiovascular disease after adjustment for tHcy, creatinine, and other cardiovascular disease risk factors.

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“…It has been suggested that confounding by renal function might explain the tHcy-CVD relationship (31 ). Renal failure has been shown to cause increased concentrations of both tHcy and tCys (32 ). In contrast to tCys, tHcy showed a strong association with CVD mortality/morbidity in the same population (4,25 ), which suggests that the renal mechanism does not fully explain the relationship between tHcy and CVD because one would then expect an artificial relationship with tCys and later morbidity/ mortality.…”

Section: Discussionmentioning

confidence: 99%

Plasma Total Cysteine, Mortality, and Cardiovascular Disease Hospitalizations: The Hordaland Homocysteine Study

et al. 2003

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Background:We have previously reported a positive association between tHcy and mortality and cardiovascular disease (CVD) hospitalizations in the Hordaland Homocysteine Study cohort. Using the same data set, we assessed the relationship between plasma total cysteine (tCys) and mortality from all causes and from cardiovascular and noncardiovascular conditions, and the association between tCys and the risk of hospitalizations from CVD. Methods: We measured plasma tCys in blood samples from 12 595 men and women 40 -42 years of age and from 4766 men and women 65-67 years of age, collected as part of the Hordaland Homocysteine Study in the year 1992-1993. Follow-up data on mortality were collected through 1999. Data on CVD hospitalizations were collected from hospital records up to May 31, 1998. Results: After a follow-up time of 6.6 -7.6 years, there were a total of 610 deaths, of which 243 were cardiovascular deaths and 367 were noncardiovascular deaths. There was no association between tCys and all-cause, cardiovascular, or noncardiovascular mortality. When we used tCys values <247.6 mol/L (lowest quartile) as the reference category, the adjusted mortality ratio (MR) for all-cause mortality at tCys concentrations of 247.6 -270.79, 270.8 -295.79, and >295.8 mol/L (highest quartile) were 1.0, 0.9, and 1.0, respectively. The adjusted MRs for cardiovascular mortality were 1.0, 1.1, and 1.1, respectively. There were no associations between tCys and 1275 CVD hospitalizations, except that tCys was

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Reduced, Free and Total Fractions of Homocysteine and Other Thiol Compounds in Plasma from Patients with Renal Failure

Cited by 74 publications

References 15 publications

Predictors of Change in Plasma Total Cysteine: Longitudinal Findings from the Hordaland Homocysteine Study

Predictors of Change in Plasma Total Cysteine: Longitudinal Findings from the Hordaland Homocysteine Study

Plasma Total Cysteine as a Risk Factor for Vascular Disease

Plasma Total Cysteine, Mortality, and Cardiovascular Disease Hospitalizations: The Hordaland Homocysteine Study

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