Reduced fractional anisotropy in the anterior corpus callosum is associated with reduced speech fluency in persistent developmental stuttering

Civier, Oren; Kronfeld-Duenias, Vered; Amir, Ofer; Ezrati-Vinacour, Ruth; Ben-Shachar, Michal

doi:10.1016/j.bandl.2015.01.012

Cited by 34 publications

(30 citation statements)

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“…This may be a compensatory means to overcome left-sided malfunctions in the motor control but perhaps also stimulus processing and inhibitory control. Decreased inhibitory regulation via corpus callosum may also activate right-sided structures abnormally, instead of beneficial compensation, as proposed by Civier et al (Civier et al, 2015). Then again, decreased white matter connectivity in CWS (Chang et al, 2015) could lead to increased temporal dispersion of N2-and P3-related processes, as well, affecting the synchronization of activity between hemispheres and thus the duration of ERP components.…”

Section: Atypical Lateralizationmentioning

confidence: 91%

“…Both children (Chang et al, 2015) and adults who stutter (Cai, S. et al, 2014;Civier et al, 2015) have shown reduced connectivity between auditory and motor areas mostly on the left side, as well as in the corpus callosum. Some of the structural and functional abnormalities found in CWS and AWS overlap areas involved in the Go/Nogo task and inhibition in general (Steele et al, 2013, for an overview, please see Chambers et al, 2009).…”

Section: Atypical Lateralizationmentioning

confidence: 99%

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Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study

Piispala

Määttä

Pääkkönen

et al. 2017

Clinical Neurophysiology

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Please cite this article as: Piispala, J., Mä ättä, S., Pä äkkönen, A., Bloigu, R., Kallio, M., Jansson-Verkasalo, E., Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study, Clinical Neurophysiology (2016), doi: http://dx.doi.org/10.1016/j.clinph. 2016.11.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study Event related potential, Go/Nogo, children, stuttering, stimulus evaluation, inhibitory control. Highlights 1. Children with stutter (CWS) show atypical brain activation compared to typically developing children (TDC) in a visual Go/Nogo task especially in the right frontal area.2. CWS had prolonged N2 in both conditions while the Nogo P3 component was diminished compared to TDC.3. Stimulus classification and/or inhibitory control may operate abnormally in the CWS. AbstractObjective: The aim of the study was to investigate inhibitory control by evaluating possible differences in the strength and distribution of the brain activity in a visual Go/Nogo task in children who stutter (CWS) compared to typically developing children (TDC).Methods: Eleven CWS and 19 TDC participated. Event related potentials (ERP) were recorded using a 64-channel EEG-cap during an equiprobable visual Go/Nogo task. The global field power (GFP) as well as the mean amplitudes in the P3 time frame were compared between groups. Additionally, the potential maps of the groups were investigated visually in the N2 and P3 time windows.Results: The groups differed significantly in the right frontal area especially in the Nogo condition Conclusions: The CWS show atypical brain activation compared to the TDC in a Go/Nogo task as indexed by the excessive N2-related activity in both conditions and reduced P3-related activity in Nogo condition.Significance: These findings indicate atypical stimulus evaluation and response inhibition processes in CWS.

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Section: Atypical Lateralizationmentioning

confidence: 91%

Section: Atypical Lateralizationmentioning

confidence: 99%

Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study

Piispala

Määttä

Pääkkönen

et al. 2017

Clinical Neurophysiology

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“…Increased FA in left forceps minor, genus of the corpus callosum, anterior thalamic radiation (ATR), and anterior corona radiata has been linked to mathematical ability (NavasSanchez et al, 2014), while stutterers have decreased FA in the forceps minor (Beal et al, 2013;Civier et al, 2015). Lesion studies have implicated left inferior frontal-occipital fasciculus (IFOF), left ATR, and left uncinate fasciculus (UF) in semantic processing (Han et al, 2013) and fluency (Almairac et al, 2014), while in healthy participants left IFOF and UF are both prominently involved in amodal (domain general) semantic memory (de Zubicaray et al, 2011).…”

Section: Wm Structural Differencesmentioning

confidence: 98%

“…FreeSurfer"s GM segmentation was verified manually for each participant, and no manual corrections were needed (for example participant"s segmentation, see Inline Supplementary 2013) 10mm smoothing kernel on the two dimension cortical surface using an iterative Heat Kernel method (Chung, 2004). The resulting CT values on the cortical surface were interpolated to a surface mesh that maintained the same number of vertices for all participants, in similar locations (using SUMA"s MapIcosahedron procedure).…”

Section: Cortical Thickness Analysismentioning

confidence: 99%

“…The main purpose of the FA analysis was to evaluate whether WM changes would be found in the vicinity of areas linked to GM or CT differences. In particular, the frontal aslant tract (Catani et al, 2013) has been implicated in fluency and stuttering (Kronfeld-Duenias et al, 2014), as has the forceps minor in the anterior corpus callosum (Civier et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Brains of verbal memory specialists show anatomical differences in language, memory and visual systems

et al. 2016

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We studied a group of verbal memory specialists to determine whether intensive oral text memory is associated with structural features of hippocampal and lateral-temporal regions implicated in language processing. Professional Vedic Sanskrit Pandits in India train from childhood for around 10years in an ancient, formalized tradition of oral Sanskrit text memorization and recitation, mastering the exact pronunciation and invariant content of multiple 40,000-100,000 word oral texts. We conducted structural analysis of gray matter density, cortical thickness, local gyrification, and white matter structure, relative to matched controls. We found massive gray matter density and cortical thickness increases in Pandit brains in language, memory and visual systems, including i) bilateral lateral temporal cortices and ii) the anterior cingulate cortex and the hippocampus, regions associated with long and short-term memory. Differences in hippocampal morphometry matched those previously documented for expert spatial navigators and individuals with good verbal working memory. The findings provide unique insight into the brain organization implementing formalized oral knowledge systems.

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Two unrelated children with overlapping 6q25.3 deletions, motor speech disorders, and language delays

Peter

Lancaster

Vose

et al. 2017

American J of Med Genetics Pt A

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Interstitial and terminal 6q25 deletions are associated with developmental delays, hypotonia, eye pathologies, craniofacial dysmorphologies, and structural brain anomalies. In most cases, speech and language deficits are not described in detail. We report on a case (Patient 1, age 7 years) with a de novo 6q25.3-qter deletion, 11.1 Mb long and encompassing 108 genes, and a case (Patient 2, age 5 years) with an inherited interstitial 6q25.3 deletion, located within Patient 1's deletion region and 403 kb long, the smallest 6q25 deletion reported to date. Both children have hypotonia, motor speech disorders, and expressive language delays. Patient 1's speech was characterized by childhood apraxia of speech (CAS) and dysarthria. Other findings include developmental delay, ataxic cerebral palsy, optic nerve dysplagia, and atypical brain morphologies regarding the corpus callosum and gyration patterns, a clinical profile that closely matches a previously reported case with a nearly identical deletion. Patient 2 had speech characterized by CAS and typical nonverbal processing abilities. His father, a carrier, had typical speech and language but showed difficulties with complex motor speech and hand motor tasks, similar to other adults with residual signs of CAS. The small deletion in this family contains the IGF2R-AIRN-SLC22A2-SLC22A3 gene cluster, which is associated with imprinting and maternal-specific expression of Igf2R, Slc22a2, and Slc22a3 in mice, whereas imprinting in humans is a polymorphic trait. The shared phenotypes in the two patients might be associated with the deletion of the gene cluster.

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Reduced fractional anisotropy in the anterior corpus callosum is associated with reduced speech fluency in persistent developmental stuttering

Cited by 34 publications

References 109 publications

Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study

Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study

Brains of verbal memory specialists show anatomical differences in language, memory and visual systems

Two unrelated children with overlapping 6q25.3 deletions, motor speech disorders, and language delays

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