Reduced Foxo3a, FoxL2, and p27 mRNA expression in human ovarian tissue in premature ovarian insufficiency

Thanatsis, Nikolaos; Kaponis, Apostolos; Koika, Vasiliki; Georgopoulos, Neoklis A.; Decavalas, George

doi:10.1007/s42000-019-00134-4

Cited by 15 publications

(8 citation statements)

References 41 publications

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“…Reportedly, the deletion of FOXO3a, FOXL2, PTEN, and p27 leads to early exhaustion of the primordial follicle pool and premature ovarian insufficiency in transgenic mice (Thanatsis et al, 2019). Melatonin prevents cisplatin-induced primordial follicle loss by suppressing the PTEN/AKT/FOXO3a pathway in the mouse ovary (Jang et al, 2016).…”

Section: Foxo3a and Ovarian Diseasementioning

confidence: 99%

“…Typically, based on morphology and function, follicular development can be artificially divided into different stages, including primordial follicles, primary follicles, secondary follicles, and mature follicles ( Wei et al, 2012 , 2019 ; Huang et al, 2016 ; Wu et al, 2019 ). Notably, various diseases could be induced by follicular dysplasia, including premature ovarian failure, polycystic follicular syndrome, and infertility ( Yang et al, 2010 ; Thanatsis et al, 2019 ). Forkhead box (Fox) proteins are highly conserved transcription factors structurally, currently attracting a great deal of attention.…”

Section: Introductionmentioning

confidence: 99%

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Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development

et al. 2020

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In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology.

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Section: Foxo3a and Ovarian Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development

et al. 2020

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“…It is worth mentioning that Foxo3a was strongly related to follicular development and fate: on the one hand, Foxo3a can inhibit the excessive activation of primordial follicles and maintain the normal reserve of the follicular pool [ 43 ]; on the other hand, follicular development was retarded, and granulosa cell proliferation was arrested with Foxo3a-specific expression [ 44 ]. Another study showed that in POI patient ovaries, the expression of Foxo3a was decreased [ 45 ]. Foxo3a is likely to regulate follicle fate by triggering Bcl-2 family members such as Bim and Bax [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency

Wang

Liu

Nie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Premature ovarian insufficiency (POI) is a common female endocrine disease that is closely linked to ovarian function. Danggui Buxue Tang (DBT) is a classic prescription of traditional Chinese medicine that is helpful for rescuing ovarian function. However, the mechanism by which DBT rescues ovarian function remains unclear. This study explored the molecular mechanism of DBT with respect to apoptosis and related signals in ovarian cells. The quality control of DBT was performed by HPLC. After DBT intervention in the POI rat model, serum AMH/FSH/LH/E2 levels were detected by ELISA, follicles at various developmental stages were observed by HE staining, apoptosis was detected by TUNEL, and the expression profiles of Bcl-2 family proteins and key proteins in the Jak2/Foxo3a signaling pathway were evaluated by western blot. The results demonstrated that DBT could encourage the development of primary/secondary/antral follicles and increase the secretion of AMH. Moreover, DBT might inhibit Foxo3a by upregulating Jak2, thereby mediating Bcl-2 family activities and inhibiting apoptosis in ovarian cells. In conclusion, DBT promotes follicular development and rescues ovarian function by regulating Bcl-2 family proteins to inhibit cell apoptosis, which could be related to the Jak2/Foxo3a signaling pathway.

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“…Multiple studies have shown decreased protein expression in POI [68][69][70][71][72], signifying the significance of a downregulated gene as a possible cause for POI.…”

Section: Glucose Metabolism In Poimentioning

confidence: 99%

Network Pharmacology Approach for Predicting Targets of Zishen Yutai Pills on Premature Ovarian Insufficiency

Feng

Chai

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background and Purpose. Premature ovarian insufficiency (POI) is a serious reproductive disease in females that is characterized by menstrual and ovulation disorders and infertility. The clinical efficacy of complementary and alternative medicine (CAM) has been reported in POI, including compound Chinese medicine. Zishen Yutai Pills (ZSYTP), a well-known patented Chinese medicine, has been widely used for treating POI; however, the pharmacological mechanism and molecular targets of ZSYTP remain unknown. Here, we systematically elucidated the pharmacological mechanism of ZSYTP on POI using a network pharmacology approach and further validated our findings with molecular docking. Methods. A comprehensive strategy based on several Chinese herb databases and chemical compound databases was established to screen active compounds of ZSYTP and predict target genes. For network pharmacological analysis, network construction and gene enrichment analysis were conducted and further verified by molecular docking. Results. A total of 476 target genes of ZSYTP were obtained from 205 active compounds. 13 herbs of ZSYTP overlapped on 8 active compounds based on the compound-target-disease network (C-T network). 20 biological processes and 9 pathways were strongly connected to the targets of ZSYTP in treating POI, including negative regulation of gene expression, mRNA metabolic process, hypoxia-inducible factor 1 (HIF-1) signaling pathway, and gluconeogenesis. Finally, molecular docking was visualized. Conclusion. Intriguingly, the signal pathways and biological processes uncovered in this study implicate inflamm-aging and glucose metabolism as potential pathological mechanisms of POI. The therapeutic effect of ZSYTP could be mediated by regulating glucose metabolism and HIF-1 signal pathway. Collectively, this study sheds light on the therapeutic potential of ZSYTP on POI.

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Reduced Foxo3a, FoxL2, and p27 mRNA expression in human ovarian tissue in premature ovarian insufficiency

Cited by 15 publications

References 41 publications

Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development

Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development

Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency

Network Pharmacology Approach for Predicting Targets of Zishen Yutai Pills on Premature Ovarian Insufficiency

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