Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals

Kim, Yeshin; Lee, Hyun; Son, Tea Ok; Cho, Soo Hyun; Kim, Si Eun; Kim, Seungjoo; Lee, Jin San; Kim, Jun Pyo; Jung, Young Hee; Lockhart, Samuel N.; Kim, Hee Jin; Na, Duk L.; Park, Hye Yun; Seo, Sang Won

doi:10.1016/j.nicl.2019.102140

Cited by 10 publications

(12 citation statements)

References 42 publications

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“…4c ). Although none were statistically significant after correction for multiple testing, these traits (age of first birth 11 , forced vital capacity 39 , squamous cell lung cancer 40 , and total cholesterol 41 ) were reported in previous studies to correlate with AD. In addition, we estimated overall SNP heritability ( ) to be 0.16 (SE = 0.06) in the Japanese GWAS data, although Lee et al 42 estimated the to be 0.24 (SE = 0.03) in the European GWAS data.…”

Section: Resultsmentioning

confidence: 71%

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

et al. 2021

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Alzheimer’s disease (AD) has no cure, but early detection and risk prediction could allow earlier intervention. Genetic risk factors may differ between ethnic populations. To discover novel susceptibility loci of AD in the Japanese population, we conducted a genome-wide association study (GWAS) with 3962 AD cases and 4074 controls. Out of 4,852,957 genetic markers that passed stringent quality control filters, 134 in nine loci, including APOE and SORL1, were convincingly associated with AD. Lead SNPs located in seven novel loci were genotyped in an independent Japanese AD case–control cohort. The novel locus FAM47E reached genome-wide significance in a meta-analysis of association results. This is the first report associating the FAM47E locus with AD in the Japanese population. A trans-ethnic meta-analysis combining the results of the Japanese data sets with summary statistics from stage 1 data of the International Genomics of Alzheimer’s Project identified an additional novel susceptibility locus in OR2B2. Our data highlight the importance of performing GWAS in non-European populations.

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Section: Resultsmentioning

confidence: 71%

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

et al. 2021

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“…Greater pulmonary function measures were significantly protective against CSVD in this study. Reduced FVC 27 , FEV1 28 and chronic obstructive pulmonary disease 29 were previously reported to increase CSVD risk. Reduced midlife lung function was associated with increased WMH in late life.…”

Section: Discussionmentioning

confidence: 90%

Validation of external and internal exposome of the findings associated to cerebral small vessel disease: A Mendelian randomization study

Zhang

Leng

et al. 2022

J Cereb Blood Flow Metab

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The exposome characterizes all environmental exposures and their impact on a disease. To determine the causally-associated components of the exposome for cerebral small vessel disease (CSVD), we performed mendelian randomization analysis of 5365 exposures on six clinical and subclinical CSVD measures. We found statistically significant evidence (FDR-corrected P < 0.05) that hypertension, high cholesterol, longer television-watching time, lower educational qualifications, younger age of first sexual intercourse, smoking, reduced pulmonary function, higher subjective overall health rating, and frequent tiredness were associated with increased risk of intracerebral hemorrhage or small vessel stroke. Adiposity, diabetes, frequent alcoholic drinks, higher white blood cell count and neutrophil count were significantly associated with higher risk of non-lobar hemorrhage or small vessel stroke, but not lobar hemorrhage. Hypertension, higher arm or leg fat-free mass and higher sitting height were significantly associated with higher white matter hyperintensities. The results were robust to sensitivity analyses and showed no evidence of horizontal pleiotropy. We also identified 41 exposures suggestively associated (uncorrected P < 0.05) with multiple CSVD measures as the “the CSVD exposome”. This exposome-wide association study provides insight into CSVD development and prevention.

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“…Two studies have shown that lower FEV1 is related to smaller volumes of gray and white matter and a greater volume of WMH 30,31 . However, another study has indicated that poor FVC, but not FEV1, is associated with increased WMH 29 . To date, no prior studies have addressed the association between PF and cognitive trajectories in different cognitive domains with supporting results from brain MRI data.…”

Section: Narrativementioning

confidence: 99%

“…25 So far, only a few studies have addressed the association between PF and structural brain differences, and with mixed results. [29][30][31] Two studies have shown that lower FEV1 is related to smaller volumes of gray and white matter and a greater volume of WMH. 30,31 However, another study has indicated that poor FVC, but not FEV1, is associated with increased WMH.…”

Section: -19 Years)mentioning

confidence: 99%

“…White matter hyperintensities (WMH) have a multifactorial pathogenesis, but are strongly associated with cerebrovascular disease and vascular risk factors and thus could reflect microvascular lesions 25 . So far, only a few studies have addressed the association between PF and structural brain differences, and with mixed results 29–31 . Two studies have shown that lower FEV1 is related to smaller volumes of gray and white matter and a greater volume of WMH 30,31 .…”

Section: Narrativementioning

confidence: 99%

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Pulmonary function is associated with cognitive decline and structural brain differences

Wang

Song

Dove

et al. 2021

Alzheimer's & Dementia

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The association of poor pulmonary function (PF) with cognitive trajectories and structural brain differences remains unclear. Within the Rush Memory and Aging Project, 1377 dementia-free subjects were followed up to 21 years. PF was assessed with a composite score measured at baseline. Global and domain-specific cognitive function was assessed annually constructed from 19 cognitive tests. A subsample of 351 participants underwent brain magnetic resonance imaging to investigate the crosssectional association between PF and structural brain volumes. We found that low PF was related to faster decline in global cognition, and domain-specific function including episodic memory, semantic memory, working memory, visuospatial ability, and perceptual speed. In addition, low PF was associated with smaller volumes of total brain, white matter and gray matter, and larger white matter hyperintensities volume. Our results suggest that low PF is associated with faster cognitive decline, and both neurodegeneration and vascular brain lesions may underlie the association.

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Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals

Cited by 10 publications

References 42 publications

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

Validation of external and internal exposome of the findings associated to cerebral small vessel disease: A Mendelian randomization study

Pulmonary function is associated with cognitive decline and structural brain differences

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