Abstract:In the attempt to understand the origin of autoantibody (AAb) production
in patients with and at-risk for T1D, multiple studies have analyzed and
reported alterations in follicular helper T cells (Tfh) in presymptomatic
AAb-positive subjects and patients with T1D. Yet, it is still not clear whether
the regulatory counterpart of Tfh cells, represented by follicular regulatory T
cells (Tfr), is similarly altered. To address this question, we performed
analyses in peripheral blood, spleen and pancreatic lymph nod… Show more
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