Reduced fibrinogen, fibrinolytic biomarkers, and physical parameters after a weight-loss program in obese subjects

Aziz, Che Badariah Abdul; Omar, Norsuhana; Abdullah, Wan Zaidah; Jalil, Rohana Abdul; Nik, Wan Suriati Wan; Zakaria, Rahimah

doi:10.4103/1947-2714.139286

Cited by 17 publications

(12 citation statements)

References 31 publications

(34 reference statements)

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“…WC and c-HDL were demonstrated in our study to be the two parameters which significantly correlated with all biomarkers of prothrombogenesis. Our findings are parallel to those reported by Aziz et al [ 19 ] who showed that WC was significantly correlated with tPA and PAI-1. However, this study did not examine the other parameters of MS and moreover had smaller sample size ( n =28) compared to ours.…”

Section: Discussionsupporting

confidence: 92%

Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome

et al. 2018

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Objective There is limited data comparing prothrombogenic or fibrinolysis biomarkers (tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)) simultaneously in subjects with Metabolic Syndrome (MS), simple central obesity without MS (COB) and normal controls (NC). We investigated the concentrations of fibrinolysis biomarkers in subjects with MS, COB and NC. Methods A cross-sectional study involving 503 drug naive subjects (163 males, aged 30–65 years old (mean age ± SD = 47.4 ± 8.3 years)) divided into MS, COB and NC groups. COB was defined as central obesity (waist circumference (WC) males ≥90 cm, females ≥80 cm) in the absence of MS according to the International Diabetes Federation 2006. Fasting blood levels of tPA and PAI-1were analyzed. Results MS and COB had significantly higher concentration of all biomarkers compared to NC. The MS group had significantly higher concentration of tPA and PAI-1 compared to COB. WC and HDL-c had significant correlation with all biomarkers (tPA p < 0.001, PAI-1 p < 0.001). Fasting plasma glucose and diastolic blood pressure were independent predictors after correcting for confounding factors. Conclusion Central obesity with or without MS both demonstrated enhanced prothrombogenesis. This suggests that simple obesity possibly increases the risk of coronary artery disease in part, via increased susceptibility to thrombogenesis.

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Section: Discussionsupporting

confidence: 92%

Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome

et al. 2018

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“…In a previous study, it was reported that impaired fibrinolysis in obesity was associated with high levels of plasminogen activator inhibitor-1 (PAI-1) and the development of CVD; however, the results also showed that there was no significant decrease in fibrinogen and PAI-1 levels following the weight loss 23. In the current study, there was a significant reduce in the level of fibrinogen after weight loss on the calorie-restricted diets.…”

Section: Discussioncontrasting

confidence: 62%

Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Özkan

Yiğit²,

Yiğit³

2019

SMJ

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Objectives: To assess the differences in the parameters that are metabolically related to cardiovascular diseases after weight loss in obese people with coronary artery diseases (CADs). Methods: This study was conducted on 184 patients who were diagnosed with CADs in Istanbul University Cardiology Institute Hospital, Istanbul, Turkey. The levels of leptin, fibrinogen, homocysteine, high-sensitivity C-reactive protein (hs-CRP), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), fasting blood glucose and insulin, glycated hemoglobin, and uric acid of the obese patients who were put on calorie restricted diet were evaluated retrospectively and compared before and after weight loss. For comparison, non-obese control patients were also studied. Student’s t-test and Chi-square test were used for the statistical analysis. Results: Levels of homocysteine, glycated hemoglobin, and leptin were significantly higher in the obese patients than in the non-obese patients. Diabetic obese patients with CADs lost (11.1%) and non-diabetic obese patients with CADs lost (10.5%) of their body weight in 6 months. The levels of cholesterol, LDL-C, and fibrinogen were significantly improved in both groups. Conclusion: The obese patients lost weight after being on calorie-restricted diets and showed significant improvement in the levels of cholesterol, LDL-C, fibrinogen. There was no significant difference in the levels of homocysteine, hs-CRP, and leptin before and after weight loss in both diabetic and non-diabetic obese patients.

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“…Visceral fat has been shown to secrete more PAI-1 than subcutaneous fat tissue in the obese phenotype 46 47 48 and WHR has been found to correlate more strongly with PAI-1 than BMI 49 50 51 . Lifestyle and dietary-mediated weight loss in the moderately overweight and obese has been associated with concomitant reductions in PAI-1 levels, further supporting a causal link between adiposity and PAI-1 expression 52 53 54 55 . However, in our review, 7 of the prospective studies that adjusted for measures of overall (BMI) or visceral adiposity (WHR or WC) maintained a significant association between PAI-1 and diabetes, though the association was attenuated in some studies.…”

Section: Discussionmentioning

confidence: 85%

Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies

Yarmolinsky

Barbieri

Weinmann

et al. 2016

Sci Rep

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An emerging body of evidence has implicated plasminogen activator inhibitor-1 (PAI-1) in the development of type 2 diabetes (T2D), though findings have not always been consistent. We systematically reviewed epidemiological studies examining the association of PAI-1 with T2D. EMBASE, PubMed, Web of Science, and the Cochrane Library were searched to identify studies for inclusion. Fifty-two studies (44 cross-sectional with 47 unique analytical comparisons and 8 prospective) were included. In pooled random-effects analyses of prospective studies, a comparison of the top third vs. bottom third of baseline PAI-1 values generated a RR of T2D of 1.67 (95% CI 1.28–2.18) with moderate heterogeneity (I2 = 38%). Additionally, of 47 cross-sectional comparisons, 34(72%) reported significantly elevated PAI-1 among diabetes cases versus controls, 2(4%) reported significantly elevated PAI-1 among controls, and 11(24%) reported null effects. Results from pooled analyses of prospective studies did not differ substantially by study design, length of follow-up, adjustment for various putative confounding factors, or study quality, and were robust to sensitivity analyses. Findings from this systematic review of the available epidemiological literature support a link between PAI-1 and T2D, independent of established diabetes risk factors. Given the moderate size of the association and heterogeneity across studies, future prospective studies are warranted.

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Reduced fibrinogen, fibrinolytic biomarkers, and physical parameters after a weight-loss program in obese subjects

Cited by 17 publications

References 31 publications

Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome

Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome

Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies

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