Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915-29

Leon, David A.; Lithell, Hans; Vågerö, Denny; Koupilová, Ilona; Mohsen, Rawya; Berglund, Lars; Lithell, Ulla-Britt; McKeigue, Paul

doi:10.1136/bmj.317.7153.241

Cited by 735 publications

(547 citation statements)

References 18 publications

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“…The association of larger birth size with increased cancer incidence in men found here is in the opposite direction to that found with circulatory diseases in this cohort 2 and in other studies. 3 Furthermore, the magnitude of the overall increase in cancer incidence in men observed here is approximately half the magnitude of the decrease in ischemic heart disease in the same cohort 2 (hazard ratio of 1.17 for cancer vs. 0.77 for IHD for 1,000 g increase in birth weight).…”

Section: Biologic Plausibilitycontrasting

confidence: 99%

See 1 more Smart Citation

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

McCormack

dos‐Santos‐Silva

Koupil

et al. 2005

Intl Journal of Cancer

120

115

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Associations between larger size at birth and increased rates of adult cancer have been proposed but few empirical studies have examined this hypothesis. We investigated overall and site-specific cancer incidence in relation to birth characteristics in a Swedish population-based cohort of 11,166 singletons born in 1915-1929 for whom we have detailed obstetric data and who were alive in 1960. A total of 2,685 first primary cancers were registered during follow-up from 1960 to 2001. A standard deviation (SD) increase in birth weight for gestational age (GA) was associated with (sexadjusted) increases of 13% (95% CI = 0.03-0.23) in the rates of digestive cancers and of 17% (95% CI = 0.01-0.35) in the rates of lymphatic cancers. Women who had higher birth weights also had increased rates of breast cancer under age 50 years (by 39% per SD increase; 95% CI = 0.09-0.79), but reduced rates (by 24%; 95% CI = 0.07-0.38) of endometrial (corpus uteri) cancer at all ages. There was no evidence of associations with other cancer sites. For overall cancer incidence, men had an 8% increased risk at all ages per SD increase in birth weight for GA while women only had an increased risk under age 50 years (mainly driven by the association with breast cancer). These findings provide evidence of a modest association of birth size and adult cancer risk, resulting from positive associations with a few cancer sites and a possible inverse association with endometrial cancer. ' 2005 Wiley-Liss, Inc.

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Section: Biologic Plausibilitycontrasting

confidence: 99%

“…2 Detailed obstetric notes were kept, providing data on maternal age, birth order, birth weight and placental weight (recorded to the nearest 10 g) and birth length and head circumference (recorded to the nearest 0.5 cm). Ponderal index, a measure of weight relative to height in infants, was calculated as birth weight/length 3 (kg/m 3 ).…”

Section: Methodsmentioning

confidence: 99%

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

McCormack

dos‐Santos‐Silva

Koupil

et al. 2005

Intl Journal of Cancer

120

115

View full text Add to dashboard Cite

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“…Intrauterine growth restriction (IUGR) is a major cause of perinatal mortality and morbidity1, 2, 3 and is associated with long‐term consequences, including impaired neurological development4 and increased risks of developing cardiovascular disease5 and metabolic syndrome6. There are no effective therapies to reverse IUGR, and antenatal management is aimed at determining the ideal time for delivery, sometimes very prematurely.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

Sohlberg

Mulic‐Lutvica

Olovsson

et al. 2015

Ultrasound in Obstet & Gyne

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ObjectiveTo evaluate in‐vivo placental perfusion fraction, estimated by magnetic resonance imaging (MRI), as a marker of placental function.MethodsA study population of 35 pregnant women, of whom 13 had pre‐eclampsia (PE), were examined at 22–40 weeks' gestation. Within a 24‐h period, each woman underwent an MRI diffusion‐weighted sequence (from which we calculated the placental perfusion fraction), venous blood sampling and an ultrasound examination including estimation of fetal weight, amniotic fluid index and Doppler velocity measurements. The perfusion fractions in pregnancies with and without fetal growth restriction were compared and correlations between the perfusion fraction and ultrasound estimates and plasma markers were estimated using linear regression. The associations between the placental perfusion fraction and ultrasound estimates were modified by the presence of PE (P < 0.05) and therefore we included an interaction term between PE and covariates in the models.ResultsThe median placental perfusion fractions in pregnancies with and without fetal growth restriction were 21% and 32%, respectively (P = 0.005). The correlations between placental perfusion fraction and ultrasound estimates and plasma markers were highly significant (P = 0.002 and P = 0.0001, respectively). The highest coefficient of determination (R 2 = 0.56) for placental perfusion fraction was found for a model that included pulsatility index in the ductus venosus, plasma level of soluble fms‐like tyrosine kinase‐1, estimated fetal weight and presence of PE.ConclusionThe placental perfusion fraction has the potential to contribute to the clinical assessment of cases with placental insufficiency. © 2015 Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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“…Hales and co-workers suggested that undernutrition during critical periods, leading to impaired development of b-cell function and muscle response to insulin, is the root cause of impaired glucose tolerance and diabetes -the 'thrifty phenotype hypothesis' (Hales et al, 1991;Barker, 1994). Many longitudinal studies have since provided supporting evidence for these hypotheses among diverse populations, mostly in high-income countries using data from historical cohorts (Hales et al, 1991;Leon et al, 1998;Bavdekar et al, 1999;Eriksson et al, 2001;Yajnik, 2001;Barker et al, 2002). This study, drawing on longitudinal birth cohort data, assessed levels of haemoglobin (Hb) A 1c in adolescence in relation to fetal growth rate in an urban Brazilian population.…”

Section: Introductionmentioning

confidence: 99%

Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

et al. 2006

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The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A 1c , an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A 1c at age 18 years, were available for 197 individuals. There was an inverse association between mean Hb A 1c and birthweight for the gestational age, but not birthweight alone. The association remained significant after adjustment for family income and mother's education, as well as for body mass index at 18 years (P for trend ¼ 0.01 and 0.03, respectively).

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Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915-29

Cited by 735 publications

References 18 publications

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

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