Reduced expression of the WW domain-containing oxidoreductase in human hematopoietic malignancies

Luo, Lingqing; Chen, Yan; Cheng, Xiao; Lin, Yazhen; Fu, Xiaodan; Li, Dan; Cui, Zhaolei; Dong, Lin

doi:10.3892/ol.2016.4495

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…A number of studies have contributed to the description of the role of this gene in leukemic malignancies. Luo et al [ 33 ] found that the expression of the WWOX mRNA and protein is significantly reduced or absent in cases of leukemia and their cell lines in comparison with the controls, which is consistent with the findings of Cui et al [ 34 ], who evaluated patients diagnosed with different types of leukemia.…”

Section: Discussionsupporting

confidence: 80%

Identification of Genomic Variants Associated with the Risk of Acute Lymphoblastic Leukemia in Native Americans from Brazilian Amazonia

Leitão

Carvalho

Rodrigues

et al. 2022

JPM

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A number of genomic variants related to native American ancestry may be associated with an increased risk of developing Acute Lymphoblastic Leukemia (ALL), which means that Latin American and hispanic populations from the New World may be relatively susceptible to this disease. However, there has not yet been any comprehensive investigation of the variants associated with susceptibility to ALL in traditional Amerindian populations from Brazilian Amazonia. We investigated the exomes of the 18 principal genes associated with susceptibility to ALL in samples of 64 Amerindians from this region, including cancer-free individuals and patients with ALL. We compared the findings with the data on populations representing five continents available in the 1000 Genomes database. The variation in the allele frequencies found between the different groups was evaluated using Fisher’s exact test. The analyses of the exomes of the Brazilian Amerindians identified 125 variants, seven of which were new. The comparison of the allele frequencies between the two Amerindian groups analyzed in the present study (ALL patients vs. cancer-free individuals) identified six variants (rs11515, rs2765997, rs1053454, rs8068981, rs3764342, and rs2304465) that may be associated with susceptibility to ALL. These findings contribute to the identification of genetic variants that represent a potential risk for ALL in Amazonian Amerindian populations and might favor precision oncology measures.

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Section: Discussionsupporting

confidence: 80%

Identification of Genomic Variants Associated with the Risk of Acute Lymphoblastic Leukemia in Native Americans from Brazilian Amazonia

Leitão

Carvalho

Rodrigues

et al. 2022

JPM

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“…Li suggests that WWOX may have potential clinical implications in bladder cancer therapy 6. In a study of 182 patients with leukemia of different types, Luo suggests WWOX has potential to be a good biomarker or predictor for leukemia therapy 7. WWOX can suppress stem cell properties in cancer stem cells, including self-renewal ability, differentiation potential, in vivo tumorigenic capability, high-level expression of stem cell genes and multidrug resistance 5…”

Section: Introductionmentioning

confidence: 99%

Expression of CD133, E-cadherin and WWOX in colorectal cancer and related analysis

et al. 2017

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Objective:To detect the expression of CD133, E-cadherin and WWOX in colorectal cancer, analyze the correlations and pathological significance of the biomarkers.Methods:Two hundred and ten patients with colorectal cancer treated surgically between January 2007 and December 2015 were analyzed retrospectively. All patients had pathologic specimens and integrated clinical data. Pathologic specimens were retrieved for immunohistochemical examination of the expressions of CD133, WWOX and E-cadherin. The clinical data of these patients including gender, age, tumor location, tumor size, tumor differentiation, invasion depth, hepatic metastases, lymphatic metastasis, UICC stage and recurrence of tumor were retrieved to investigate their demographics and clinical characteristics.Results:In 210 specimens of colorectal cancer, the positive expression rate of CD133, E-cadherin and WWOX was 61.9%, 40.5% and 41.9%, respectively. The expression of CD133, E-cadherin and WWOX was significantly correlated with lymphatic metastasis, hepatic metastases and UICC stage (p<0.05). The expression of CD133 was negatively correlated with WWOX and E-cadherin (p<0.05), and the expression of WWOX was positively correlated with E-cadherin in specimens (p<0.05).Conclusion:A detection of CD133, E-cadherin and WWOX can facilitate physicians in predicting the progression and prognosis of colorectal cancer.

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“…Luo ve ark. WWOX ifadesinin farklı lösemi tiplerinde normal kontrollere kıyasla azaldığını veya kaybolduğunu göstermişlerdir23 . Chen ve ark.…”

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WWOX Gen İfadesinin Kronik Lenfositik Lösemi ile İlişkisi

Hancı¹,

Topçu²,

Akpınar³

et al. 2020

Namık Kemal Tıp Dergisi

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76/07/11) ve Helsinki Bildirgesi'nin talimatlarına uygun olarak gerçekleştirildi. Öz Amaç: WW alanı içeren oksidoredüktaz (WWOX) geni kromozom 16q23.3-q24.1 bölgesinde bulunmaktadır ve yaygın kromozomal frajil bölge, FRA16D, içermektedir. WWOX geni 46 kDa moleküler ağırlığında WWOX tümör baskılayıcı proteini kodlar. Birçok insan kanserlerinde WWOX lokusunda heterozigozite kaybı (LOH), WWOX promoter hipermetilasyonu ve sonuç olarak Wwox ifadesi kaybı veya azalması bildirilmiştir. Ayrıca, son çalışmalar çeşitli kanser tiplerinde Wwox eksikliğinin kötü prognoz ile ilişkili olduğunu göstermiştir. Kronik lenfositik löseminin (KLL) klinik özellikleri ve genetik anomalileri iyi tanımlanmıştır, fakat moleküler detaylar halen araştırılmaktadır. WWOX ifadesi seviyeleri KLL için olası bir biyobelirteç olabilir. Bildiğimiz kadarıyla literatürde KLL'de WWOX'ın tanı ve prognostik önemi ile ilgili kanıtlar bulunmamaktadır. Çalışmamızda, KLL hastalarında ve sağlıklı kontrollerde WWOX ifadesi düzeylerini tanımlamayı ve KLL hastalarında WWOX ifadesini klinik özelliklerine göre analiz etmeyi amaçladık. Materyal ve Metot:Bu çalışmayı 40 KLL hastasında ve 26 sağlıklı kontrolde gerçekleştirdik. WWOX ifadesi seviyelerini ters transkriptaz kantitatif PCR (RT-QPCR) tekniğini kullanarak analiz ettik.Bulgular: Sonuçlarımız WWOX ifadesinin KLL hastalarında sağlıklı kontrol grubuna göre anlamlı derecede yüksek olduğunu gösterdi (P<0,001). WWOX düzeyleri ile KLL'deki klinik parametreler arasında istatistiksel olarak anlamlı bir fark bulmadık (P>0,05). Sonuç: Sonuç olarak, WWOX geninin anormal transkripsiyon varyantları, anormal protein izoformları ile ilişkilendirilebilir ve bu izoformlar, KLL hastalarında WWOX geninin tümör baskılayıcı etkilerini değiştirebilir.

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Reduced expression of the WW domain-containing oxidoreductase in human hematopoietic malignancies

Cited by 3 publications

References 27 publications

Identification of Genomic Variants Associated with the Risk of Acute Lymphoblastic Leukemia in Native Americans from Brazilian Amazonia

Identification of Genomic Variants Associated with the Risk of Acute Lymphoblastic Leukemia in Native Americans from Brazilian Amazonia

Expression of CD133, E-cadherin and WWOX in colorectal cancer and related analysis

WWOX Gen İfadesinin Kronik Lenfositik Lösemi ile İlişkisi

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