Reduced expression of the metastasis suppressor gene KAI1 in advanced colon cancer and its metastases

Maurer, Christoph A.; Graber, H.U.; Friess, Helmut; Beyermann, Beate; Willi, Doris; Netzer, Peter; Zimmermann, Arthur; Büchler, Markus W.

doi:10.1016/s0039-6060(99)70028-0

Cited by 34 publications

(9 citation statements)

References 21 publications

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“…(b) In contrast, only few cells (arrows) show weak positivity in a breast cancer brain metastasis. Nm23 expression in tendency was comparable in breast cancer primary tumors (c) and brain metastases (d) (magnification ·400) There is evidence that KAI1 expression is down-regulated in advanced breast and colorectal cancer (Maurer et al 1999;Yang et al 1997;Yang et al 2000). Notably, a correlation between reduced metastasis in the MDA-MB-435 model system and increased expression of KAI1 protein has been described (Philips et al 1998).…”

Section: Discussionmentioning

confidence: 94%

Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases

Stark¹,

Tongers²,

Maass³

et al. 2004

J Cancer Res Clin Oncol

128

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Section: Discussionmentioning

confidence: 94%

Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases

Stark¹,

Tongers²,

Maass³

et al. 2004

J Cancer Res Clin Oncol

128

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“…27 The present study showed that KAI1 expression was higher in colorectal adenomas and carcinomas than in normal mucosa. Maurer et al 28 showed that KAI1 expression was higher in stages II and III than in stage IV in colorectal cancers. Reduced KAI1 gene expression is thought to contribute to the invasiveness and metastatic ability of colon cancer cells.…”

Section: Discussionmentioning

confidence: 99%

KAI1 , CAR , and Smad4 expression in the progression of colorectal tumor

Mikami

Ookawa

Shimoyama

et al. 2001

Journal of Gastroenterology

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“…CD81 knockout leads to a reduction of expression a Simultaneous reduction of CD9 and CD82 has an additive effect on metastatic potential and is a bad prognosis factor [121,125].…”

Section: Tetraspanins In Organ Functions and Diseasesmentioning

confidence: 99%

Tetraspanins

Boucheix¹,

Rubinstein²

2001

CMLS, Cell. Mol. Life Sci.

570

629

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The first tetraspanins were discovered on surface of human leucocytes, but it was rapidly demonstrated that they had a wider tissue expression. Twenty-six molecules display sufficient homology to belong to the same superfamily. Their function is not precisely known, but data coming from biochemical studies or knockout mice suggest that they play a major role in membrane biology. One of their outstanding properties is their ability to form a network of multimolecular complexes, the 'tetraspanin web', in which integrins are included. The structure of these complexes is under investigation, but some of the rules that govern their organization have already been unraveled. The challenge is to determine how the organization of the 'tetraspanin web' modifies the function of its constitutive molecules and consequently influences cellular behaviour. The implications may be considerable for the understanding of basic cellular processes such as migration and also of diseases related to loss or mutation of a single tetraspanin.

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Reduced expression of the metastasis suppressor gene KAI1 in advanced colon cancer and its metastases

Cited by 34 publications

References 21 publications

Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases

Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases

KAI1 , CAR , and Smad4 expression in the progression of colorectal tumor

Tetraspanins

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