Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer

Li, Li; Du, Meilin; Wang, Chao; He, Ping

doi:10.21037/jtd-20-2977

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…circRNA_102179 promoted the proliferative, migratory, and invasive abilities in NSCLC through the miR-330-5p/HMGB3 axis [ 24 ]. Additionally, several circRNAs also present potential clinical diagnosis value in NSCLC, including circ_0005280, circFARSA, and circRNA_102231 [ 13 , 25 , 26 ]. Our present study have illustrated that hsa_circ_0077837 elevation inhibited cell viability, migration, and invasion in NSCLC and enhanced apoptosis in vitro and inhibited tumorigenesis in vivo .…”

Section: Discussionmentioning

confidence: 99%

hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis

Jiang

Ya-qian

2022

Journal of Oncology

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Objective. circRNAs were a group of the most promising molecular biomarkers for clinical prognosis and diagnosis of non-small cell lung cancer (NSCLC). It was a pity that academic circle still struggled to figure out how circRNAs acted on NSCLC. This article aimed to study the function and mechanism of hsa_circ_0077837 in NSCLC progression. Methods. Cell viability was measured via CCK-8, while apoptosis was evaluated with flow cytometry. The transwell assay and scratch test were used to detect invasion and migration, respectively. The dual-luciferase reporter gene assay verified the regulatory effect of miR-1178-3p on hsa_circ_0077837 and miR-1178-3p on apoptosis-inducing, TAF9-like domain 1 (APITD1). The TUNEL assay and immunohistochemistry were used to assess cells apoptosis and proliferation in lung tumor tissues in mice. Results. Hsa_circ_0077837 and APITD1 expression were suppressed in NSCLC tissues and cells, and miR-1178-3p level was promoted. High amount of hsa_circ_0077837 intensely prevented cell proliferation, migration, and invasion, promoted cell apoptosis in vitro, and delayed tumor growth in mice. Further analysis indicated that hsa_circ_0077837 acted as a miR-1178-3p sponge to stabilize APITD1, the target of miR-1178-3p. Mechanistically, we discovered that hsa_circ_0077837 could prevent proliferation, viability, migration, and invasion of NSCLC cells through stimulating the miR-1178-3p/APITD1 pathway. Conclusion. Collectively, our findings validated that hsa_circ_0077837 served as a miR-1178-3p sponge by targeting APITD1 that alleviated NSCLC progression.

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Section: Discussionmentioning

confidence: 99%

hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis

Jiang

Ya-qian

2022

Journal of Oncology

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“…For example, it was reported that circRNA_102231 showed increased expression in lung cancer with an area under the ROC curve (AUC) of 0.897, 99 and circ_0005280 was significantly decreased in NSCLC with an AUC of 0.994. 100 Moreover, plasma circ_0001715 levels in lung adenocarcinoma patients were significantly higher than in controls, ROC curve analysis showed that circ_0001715 had a high diagnostic value for lung adenocarcinoma, and the AUC was 0.871. 101 Higher plasma levels of exo-circRNA_0056616 suggested lymph node metastasis of lung adenocarcinoma with an AUC of 0.812.…”

Section: Clinical Prospects Of Circular Rnas In Nsclcmentioning

confidence: 94%

“…The receiver operating characteristic (ROC) curve was used to analyze the sensitivity and specificity of circRNA as a novel tumor biomarker. For example, it was reported that circRNA_102231 showed increased expression in lung cancer with an area under the ROC curve (AUC) of 0.897, 99 and circ_0005280 was significantly decreased in NSCLC with an AUC of 0.994 100 . Moreover, plasma circ_0001715 levels in lung adenocarcinoma patients were significantly higher than in controls, ROC curve analysis showed that circ_0001715 had a high diagnostic value for lung adenocarcinoma, and the AUC was 0.871 101 .…”

Section: Clinical Prospects Of Circular Rnas In Nsclcmentioning

confidence: 99%

Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application

et al. 2022

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Lung cancer is one of the high malignancy-related incidence and mortality worldwide, accounting for about 13% of total cancer diagnoses. Currently, the use of anti-cancer agents is still the main therapeutic method for lung cancer.However, cancer cells will gradually show resistance to these drugs with the progress of treatment. And the molecular mechanisms underlying chemotherapy agents resistance remain unclear. circRNAs are newly identified noncoding RNAs molecules with covalently closed circular structures. Previous studies have shown that circRNAs are associated with tumorigenesis and progression of various cancers, including lung cancer. Recently, growing reports have suggested that circRNAs could contribute to drug resistance of lung cancer cell through different mechanisms. Therefore, in this review, we summarized the functions and underlying mechanisms of circRNAs in regulating chemoresistance of lung cancer and discussed their potential applications for diagnosis, prognosis, and treatment of lung cancer.

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“… 183 novel_circ_0005280 down diagnostic and prognostic biomarker low expression of novel_circ_0005280 predicts poor prognosis in NSCLC patients; AUC = 0.944; cutoff 10.23; sensitivity 85.2%; specificity 95.1%; tumor diameter, p = 0.001; and age, p = 0.021 Li et al. 184 hsa_circ_0002130 up diagnostic biomarker hsa_circ_0002130 is highly expressed in serum exosomes from osimertinib-resistant NSCLC patients and shows diagnostic value for NSCLC patients; AUC = 0.792, 95% CI 0.676–0.909 (p < 0.005) Ma et al. 185 hsa_circ_0046264 up diagnostic and prognostic biomarker high expression of hsa_circ_0046264 shows diagnostic and prognostic value for NSCLC patients; AUC = 0.971, sensitivity 95.1%, and specificity 97.3% in the tumor tissues; AUC = 0.915, sensitivity 92.7%, and specificity 95.7% in the serum of the patients; expression of hsa_circ_0046264 is associated with TNM stage (p = 0.015), age (p = 0.03), tumor size (p = 0.017), lymph node metastasis (p = 0.004), and OS (p < 0.05) Liu et al.…”

Section: Clinical Applications Of Circrnas In Nsclcmentioning

confidence: 99%

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Liu

et al. 2022

Molecular Therapy - Nucleic Acids

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Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of LC and accounts for more than 80% of all cases. Circular RNAs (circRNAs) are a large class of non-coding RNAs (ncRNAs) with covalently closed-loop structures, a high abundance, and tissue-specific expression patterns. They participate in various pathophysiological processes by regulating complex gene networks involved in proliferation, apoptosis, migration, and epithelial-to-mesenchymal transition (EMT), as well as metastasis. A growing number of studies have revealed that the dysregulation of circRNAs contributes to many aspects of cancer progression, such as its occurrence, metastasis, and recurrence, suggesting their great potential as efficient and specific biomarkers in the diagnosis, prognosis, and therapeutic targeting of NSCLC. In this review, we systematically elucidate the characteristics, biogenesis, and functions of circRNAs and focus on their molecular mechanisms in NSCLC progression. Moreover, we highlight their clinical implications in NSCLC treatment.

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Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer

Abstract: the mid or advanced stage when they are diagnosed (2,4). Therefore, approaches for preventing and treating NSCLC are needed. It is also important to develop methods for the early diagnosis and accurate prognosis of NSCLC.Circular RNAs (circRNAs) are endogenous non-coding

Cited by 9 publications

References 32 publications

hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis

hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis

Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

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