Reduced expression of circ<scp>RNA</scp> hsa_circ_0003159 in gastric cancer and its clinical significance

Mao, Tian; Chen, Ruoyu; Li, Tianwen; Xiao, Bingxiu

doi:10.1002/jcla.22281

Cited by 122 publications

(90 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to being a microRNA “sponge” or regulator of gene transcription [34], circRNAs not only can produce pseudogenes to alter the genomic DNA composition [18, 20, 35] but also possess a protein translation function [19]. Moreover, as prevalent molecules in eukaryotic cells, circRNAs are expressed abnormally in many types of cancer diseases and are closely related to the occurrence and development of cancer [32, 36, 37]. This evidence reveals that circRNAs can provide potential targets for the clinical diagnosis and prognosis of cancer.…”

Section: Discussionsupporting

confidence: 47%

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

Zhao

Wang

et al. 2017

Cell Physiol Biochem

105

View full text Add to dashboard Cite

Background/Aims: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still no effective early diagnosis methods for patients to be cured in a timely manner. Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. However, it is still a puzzle as to which specific circRNAs are involved in the development of early-stage lung adenocarcinoma. Methods: Tumor samples and paired adjacent normal tissues from 4 patients with early-stage lung adenocarcinoma were selected to investigate the expression profile of circRNAs by using a high-throughput circRNA microarray. Bioinformatic analyses were conducted to screen those differentially expressed circRNAs. qRT-PCR and sequencing were performed to assure the microarray data. Results: A total of 357 circRNAs were dysregulated in the tumor samples, which suggests potential roles in lung cancer. qRT-PCR detection showed that five selected circRNAs were identical to the microarray data, and the potential circRNA-miRNA interactions were predicted. Conclusion: This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer.

show abstract

Section: Discussionsupporting

confidence: 47%

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

Zhao

Wang

et al. 2017

Cell Physiol Biochem

105

View full text Add to dashboard Cite

show abstract

“…The hsa_circ_0003159 levels were first detected in 108 paired gastric cancer tissues and adjacent nontumorous tissues from surgical patients with gastric cancer. Compared with paired adjacent non-tumorous tissues, hsa_circ_0003159 expression was significantly down-regulated in gastric cancer tissues and significantly negatively associated with gender, distal metastasis, and tumor-node-metastasis stage [34]. Similarly, hsa_circ_0014717 was significantly down regulated as well in gastric cancer tissues and related to tumor stage, distal metastasis, tissue carcinoembryonic antigen and carbohydrate antigen 19-9 expression [35].…”

Section: Correlation Of Circrnas To Gastric Cancersupporting

confidence: 46%

Landscape of Circular RNAs in the Clinical Application of Digestive System Neoplasm

Zhou¹,

Fu²,

Hu³

et al. 2018

Chemotherapy

View full text Add to dashboard Cite

It has been confirmed that noncoding RNAs (ncRNAs) play an important role in cellular development, differentiation, proliferation and apoptosis of various carcinomas. As a member of the ncRNAs family, circular RNAs (circRNAs) are getting new research hotspots because of their newly discovered and numerous potential functions such as acting as microRNA (miRNA) sponges and binding to RNA-binding proteins (RBPs) to modulate the gene transcription. Herein, we review the current understanding of the roles of circRNAs in the clinical application of digestive system neoplasm and provide a new insight into the potential implications in the diagnosis and targeted therapy of digestive system carcinomas.

show abstract

“…Zhuang et al () report that hsa_circ_0005836 was significantly down‐regulated in the peripheral blood mononuclear cells, serving as a novel potential biomarker for pulmonary tuberculosis infection(Zhuang et al, ). In gastric cancer tissues, Tian, Chen, Li, and Xiao () reported that hsa_circ_0003159 expression was significantly down‐regulated, acting as a potential cancer marker of patients with gastric cancer. In breast cancer, Zhang et al () reported circulating circular RNA hsa_circ_0001785 was up‐regulated in plasma and had better diagnostic accuracy (AUC = 0.784) (Yin et al, ).…”

Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR‐486/CDK4 pathway

Zheng

Tan

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

Recent studies have revealed that circular RNAs (circRNAs) play important roles in the tumorigenesis of human cancer, including hepatocellular carcinoma (HCC). In present study, we screen the circular RNA expression profiles in HCC tissue and investigate the molecular roles on HCC tumorigenesis. Human circRNA microarray analysis showed there were total 1,245 differently expressed circular RNAs, including 756 up-regulated circRNAs and 489 down-regulated circRNAs, in three pairs of HCC tissue and adjacent normal tissue. Hsa_circ_0016788 was identified to be up-regulated in both HCC tissue and cell lines. Loss-of-functional experiments in vivo and vitro revealed that hsa_circ_0016788 silencing inhibited the proliferation, invasion and promoted the apoptosis in vitro, and inhibited the tumor growth in vivo. Bioinformatics tools and luciferase reporter assay validated that miR-486 targeted hsa_circ_0016788 and CDK4 accompanying with negatively correlated expression, suggesting the hsa_circ_0016788/miR-486/CDK4 pathway. Receiver operating characteristic (ROC) curve showed that hsa_circ_0016788 had high diagnostic value (AUC = 0.851). In summary, results reveal the role of hsa_circ_0016788/miR-486/CDK4 in HCC tumorigenesis, providing a novel therapeutic target for HCC.

show abstract

Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance

Abstract: All of the results suggest that hsa_circ_0003159 may be a potential cancer marker of patients with gastric cancer.

Cited by 122 publications

References 17 publications

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

Landscape of Circular RNAs in the Clinical Application of Digestive System Neoplasm

Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR‐486/CDK4 pathway

Contact Info

Product

Resources

About