Reduced exploratory activity of audiogenic seizures suceptible Wistar rats

García-Cairasco, Norberto; Oliveira, José Antônio Cortes de; Wakamatsu, Hidefumi; Bueno, Salomão; Guimarães, Francisco Silveira

doi:10.1016/s0031-9384(98)00129-2

Cited by 61 publications

(43 citation statements)

References 22 publications

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“…Recently, several anomalies in other behavioral attributes, such as exploratory activity, have been reported [55]. The latency, presence of phases, seizure resolution, and kinetic-postural descriptions have all been utilized as instruments to evaluate audiogenic seizures.…”

Section: Audiogenic Susceptibilitymentioning

confidence: 99%

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Muñoz

Carballosa-Gautam

Yanowsky

et al. 2017

Epilepsy & Behavior

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The hamster has been previously described as a paroxysmal dystonia model, but our strain is currently recognized as a model of audiogenic seizures (AGS). The original first epileptic hamster appeared spontaneously at the University of Valladolid, where it was known as the GPG:Vall line, and was transferred to the University of Salamanca where a new strain was developed, named GASH:Sal. By testing auditory brainstem responses, the GASH:Sal exhibits elevated auditory thresholds that indicate a hearing impairment. Moreover, amplified fragment length polymorphism analysis distinguished genetic differences between the susceptible GASH:Sal hamster strain and the control Syrian hamsters. The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic-clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem. The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.This article is part of a Special Issue entitled Genetic Models-Epilepsy.

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Section: Audiogenic Susceptibilitymentioning

confidence: 99%

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Muñoz

Carballosa-Gautam

Yanowsky

et al. 2017

Epilepsy & Behavior

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show abstract

“…The following parameters were considered: the number of squares crossed; the number of rearings and grooming reactions and the number of center entries during 10 min test. Lower activity in the open field test is usually taken as a measure of a higher level of anxiety and vice versa (Garcia-Cairasco et al, 1998).…”

Section: Open Field Testmentioning

confidence: 99%

Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity

et al. 2013

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“…The following parameters were considered: the time spent in the center, the number of rearings, the total distance moved, and the mean velocity during the 10-min test. Lower activity in the open-field test is usually taken as a measure of a higher level of anxiety/emotionality and vice versa [44].…”

Section: Open-field Testmentioning

confidence: 99%