Reduced exercise arteriovenous O₂difference in Type 2 diabetes

Abstract

Maximal O(2) consumption (Vo(2 max)) is lower in individuals with Type 2 diabetes than in sedentary nondiabetic individuals. This study aimed to determine whether the lower Vo(2 max) in diabetic patients was due to a reduction in maximal cardiac output (Q(max)) and/or peripheral O(2) extraction. After 11 Type 2 diabetic patients and 12 nondiabetic subjects, matched for age and body composition, who had not exercised for 2 yr, performed a bicycle ergometer exercise test to determine Vo(2 max), submaximal cardiac output, Q(max), and arterial-mixed venous O(2) (a-v O(2)) difference were assessed. Maximal workload, Vo(2 max), and maximal a-v O(2) difference were lower in Type 2 diabetic patients (P < 0.05). Q(max) was low in both groups but not significantly different: 11.2 and 10.0 l/min for controls and diabetic patients, respectively (P > 0.05). Submaximal O(2) uptake and heart rate were lower at several workloads in diabetic patients; respiratory exchange ratio was similar between groups at all workloads. Vo(2 max) was linearly correlated with a-v O(2) difference, but not Q(max) in diabetic patients. These data suggest that a reduction in maximal a-v O(2) difference contributes to a decreased Vo(2 max) in Type 2 diabetic patients.

Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus

“…The a−vO 2 , calculated using the Fick equation and measured cardiac output and oxygen uptake, is lower during exercise in adult type 2 diabetic patients [5], but not in diabetic adolescents. Baldi et al [5] found that a−vO 2 was lower during exercise in type 2 diabetic adults and postulated that impaired endothelial function may have effected a maldistribution of blood to exercising muscle.…”

“…Baldi et al [5] found that a−vO 2 was lower during exercise in type 2 diabetic adults and postulated that impaired endothelial function may have effected a maldistribution of blood to exercising muscle. In contrast, we found that a−vO 2 was the same in diabetic as in non-diabetic adolescents.…”

“…Cardiac output, a−vO 2 and stroke volume were then determined at rest and during submaximal exercise using CO 2 rebreathing (equilibration method) [5]. To eliminate the potentially confounding effects of heart rate on stroke volume, measurements were taken at rest and while participants pedalled at workloads that elicited heart rates of 100 and 120 beats per min.…”

Systolic and Diastolic Abnormalities Reduce the Cardiac Response to Exercise in Adolescents With Type 2 Diabetes

“…Diabetes Care 2014;37:143937: -144637: | DOI: 10.233737: /dc13-2031 Exercise is a standard recommendation in the management and prevention of type 2 diabetes mellitus (T2DM) (1,2). Regrettably, people with diabetes often have reduced cardiac reserve (3,4) and a resultant decrease in aerobic capacity (3,5). Adults with T2DM have smaller left ventricular stroke volume (6) and reduced heart rates (3,7) during peak exercise.…”

Pokazateli gazoobmena u bol'nykh s sakharnym diabetom 2 tipa po dannym spiroergometrii

“…В то же время, в исследовании J.C. Baldi и соавт. [3] не выявлено различий между показателями максимального сердечного выброса у диабетиков и лиц без диабета, сопоставимых по уровню физи-ческой активности, индексу массы тела и возрасту. В данной работе выявлено снижение максимальной артерио-венозной разницы по содержанию кислорода на 19% в сравнении с груп-пой контроля.…”