Reduced excitability of the cortico-spinal system during the warning period of a reaction time task

Touge, Tetsuo; Taylor, Janet L.; Rothwell, John C.

doi:10.1016/s0924-980x(98)00050-2

Cited by 87 publications

(114 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was in line with previous studies reporting decreased CS excitability towards the end of the preparation period (Davranche et al 2007;Hasbroucq et al 1997) that was linked to the prevention of erroneous premature responding (Davranche et al 2007;Duque and Ivry 2009;Touge et al 1998). In addition, our observations revealed a significant interaction between age and side.…”

Section: Discussionsupporting

confidence: 93%

“…It is assumed that suppression of CS excitability is necessary to prevent erroneous premature responding (Davranche et al 2007;Duque and Ivry 2009;Touge et al 1998). During response generation, however, it has been reported that CS excitability is increased in the agonist muscle of the selected hand towards voluntary electromyographical (EMG) signal onset (Chen et al 1998;Chen and Hallett 1999;Leocani et al 2000).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Age-related differences in corticospinal excitability during a choice reaction time task

Cuypers

Thijs

Duqué

et al. 2012

AGE

View full text Add to dashboard Cite

Age-related declines in central processing may affect corticospinal (CS) excitability that underlies the emergence of voluntary responses to external stimuli. We used single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex to explore the evolution of CS excitability in 14 young and ten elderly healthy right-handed participants. Motor-evoked potentials (MEPs) were elicited in the right or left first dorsal interosseus (FDI) during the preparatory and premotor periods of a choice reaction time (CRT) task, which required selection of left or right index finger responses. Both age groups showed significant suppression of CS excitability in the preparatory period. However, suppression was generally less pronounced in older than in young adults. Moreover, our data indicated that a reduced suppression in the right FDI during the preparatory period was associated with longer reaction times (RTs) in older adults only. In the premotor period, both age groups demonstrated comparable facilitation levels towards movement onset. Our findings indicate that increased RTs among older individuals could be directly associated with declines in preparatory processes.

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Age-related differences in corticospinal excitability during a choice reaction time task

Cuypers

Thijs

Duqué

et al. 2012

AGE

View full text Add to dashboard Cite

show abstract

“…Although some studies have shown an increase in corticospinal excitability during movement preparation (e.g., Van den Hurk et al 2007;), the results have been mixed with some studies Wnding no eVect (Young et al 2000) or even a decrease in corticospinal excitability (Touge et al 1998;Hasbroucq et al 1999) during instructed delay periods. As discussed in the" Introduction", these conXicting results might be partly explained by diVerences across studies in the timing of the response, and therefore in the degree of preparation , or in the timing of the TMS pulse (Takei et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have reported a decrease in corticospinal excitability during instructed delay periods, but no response-speciWc change in corticospinal excitability (e.g., Touge et al 1998;Hasbroucq et al 1999). Conversely, some recent studies reported increases in corticospinal excitability, speciWc to the prepared response (Van den Hurk et al 2007;).…”

Section: Introductionmentioning

confidence: 99%

Effects of motor preparation and spatial attention on corticospinal excitability in a delayed-response paradigm

et al. 2007

View full text Add to dashboard Cite

The preparation of motor responses during the delay period of an instructed delay task is associated with sustained neural Wring in the primate premotor cortex. It remains unclear how and when such preparation-related premotor activity inXuences the motor output system. In this study, we tested modulation of corticospinal excitability using single-pulse transcranial magnetic stimulation (TMS) during a delayed-response task. At the beginning of the delay interval participants were either provided with no information, spatial attentional information concerning location but not identity of an upcoming imperative stimulus, or information regarding the upcoming response. Behavioral data indicate that participants used all information available to them. Only when information concerning the upcoming response was provided did corticospinal excitability show diVerential modulation for the eVector muscle compared to other task-unrelated muscles. We conclude that modulation of corticospinal excitability reXects speciWc response preparation, rather than non-speciWc event preparation.

show abstract

“…Based on previous work (Hasbroucq et al, 1997(Hasbroucq et al, , 1999Touge et al, 1998;Cattaneo et al, 2005;Prabhu et al, 2007), we predicted that the PMC-M1 network would facilitate paired-pulse MEPs relative to single-pulse MEPs during grasp preparation in an object and muscle specific manner. Be-cause the "dorsal stream" is preferentially involved in on-line visuomotor control, we predicted that such facilitation would be stronger when current visual input, as opposed to memory cues, specified which object to grasp.…”

Section: Introductionmentioning

confidence: 99%

On-Line Control of Grasping Actions: Object-Specific Motor Facilitation Requires Sustained Visual Input

Prabhu¹,

Lemon²,

Haggard³

2007

J. Neurosci.

View full text Add to dashboard Cite

Dorsal stream visual processing is generally considered to underlie visually driven action, but when subjects grasp an object from memory, as visual information is not available, ventral stream characteristics emerge. In this study we use paired-pulse transcranial magnetic stimulation (TMS) to investigate the importance of the current visual input during visuomotor grasp. Previously, the amplitude of the paired-pulse motor evoked potentials (MEPs) in hand muscles before movement onset have been shown to predict the subsequent pattern of muscle activity during grasp. Specific facilitation of paired-pulse MEPs may reflect premotor-motor (PMC-M1) cortex connectivity. Here we investigate the paired-pulse MEPs evoked under memory-cued and visually driven conditions before grasping one of two possible target objects (a handle or a disc). All trials began with a delay period of 1200 ms. Then, a TMS pulse served as the cue to reach, grasp and hold the target object for 0.5 s. Total trial length was 5 s. Both objects were continually visible in both conditions, but the way in which the target object was designated differed between conditions. In the memory-cued condition, the target object was illuminated for the first 200 ms of the trial only. In the visually driven condition, the target object was illuminated throughout the 5 s trial. Thus, the conditions differed in whether or not the object to be grasped was designated at the time of movement initiation. We found that the pattern of paired-pulse MEP facilitation matched the pattern of object-specific muscle activity only for the visually driven condition. The results suggest that PMC-M1 connectivity contributes to action selection only when immediate sensory information specifies which action to make.

show abstract

Reduced excitability of the cortico-spinal system during the warning period of a reaction time task

Cited by 87 publications

References 15 publications

Age-related differences in corticospinal excitability during a choice reaction time task

Age-related differences in corticospinal excitability during a choice reaction time task

Effects of motor preparation and spatial attention on corticospinal excitability in a delayed-response paradigm

On-Line Control of Grasping Actions: Object-Specific Motor Facilitation Requires Sustained Visual Input

Contact Info

Product

Resources

About