“…Deficiencies of PDC and a-ketoglutarate dehydrogenase have been found in various tissues by some workers Maruyama and Yamaguchi, 1984) while others have found normal activity (Evans, 1983). Methodological problems may have contributed to the confusion and in some cases methodological errors have led to subsequent retractions (Kark et al, 1980(Kark et al, , 1981. Deficiencies of PDC have also been described in Huntington's disease (Sorbi et al, 1982;Butterworth et al, 1981), Alzheimer's disease (Sorbi et al, 1982) and Reye's syndrome .…”