2011
DOI: 10.1038/ajh.2011.115
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Reduced Dietary Salt for the Prevention of Cardiovascular Disease: A Meta-Analysis of Randomized Controlled Trials (Cochrane Review)

Abstract: Despite collating more event data than previous systematic reviews of RCTs (665 deaths in some 6,250 participants) there is still insufficient power to exclude clinically important effects of reduced dietary salt on mortality or CVD morbidity. Our estimates of benefits from dietary salt restriction are consistent with the predicted small effects on clinical events attributable to the small BP reduction achieved.

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Cited by 260 publications
(178 citation statements)
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“…In addition, there was a high proportion (33.9%) of exclusions, mainly due to inadequate urine collections. In the Cochrane meta-analysis of the randomized trials, 14 one of these trials in heart failure 17 should not have been included because the participants were severely salt-and water-depleted due to aggressive diuretics therapy (furosemide 250-500 mg twice daily). The optimal salt intake is not clear, at present, but there is no doubt that salt reduction is mandatory in any country in which salt consumption is extremely high, such as Japan.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, there was a high proportion (33.9%) of exclusions, mainly due to inadequate urine collections. In the Cochrane meta-analysis of the randomized trials, 14 one of these trials in heart failure 17 should not have been included because the participants were severely salt-and water-depleted due to aggressive diuretics therapy (furosemide 250-500 mg twice daily). The optimal salt intake is not clear, at present, but there is no doubt that salt reduction is mandatory in any country in which salt consumption is extremely high, such as Japan.…”
Section: Discussionmentioning
confidence: 99%
“…6 There has been much debate concerning this article and a subsequent Cochrane Review. [14][15][16] For example, in the cohort study, 6 a single 24-h urine sample, which was used for all of the analysis, could not represent the usual salt intake at the individual level. In addition, there was a high proportion (33.9%) of exclusions, mainly due to inadequate urine collections.…”
Section: Discussionmentioning
confidence: 99%
“…Including family members in HF treatment -particularly regarding adherence to nonpharmacological measures -appears crucial and has been gaining ground as a self-care strategy. [24,25] A US study that sought to assess the effect of educational sessions geared to the family members of HF patients showed a significant reduction in sodium intake among patients whose family members received the intervention. [23] Family education is an effective strategy; however, grocery shopping, making meals, and eating together are important elements of family interaction.…”
Section: Published By Sciedu Pressmentioning
confidence: 99%
“…Moreover, two meta-analyses presented the data from randomized controlled trials on salt restriction and cardiovascular mortality. Taylor et al [124] analyzed the effect of sodium restriction on the blood pressure status at baseline (normotensive vs hypertensive). They found a tendency to better cardiovascular outcomes when patients were salt-restricted [124].…”
Section: Hypertension and Kidney Diseases Update 2011mentioning
confidence: 99%
“…Taylor et al [124] analyzed the effect of sodium restriction on the blood pressure status at baseline (normotensive vs hypertensive). They found a tendency to better cardiovascular outcomes when patients were salt-restricted [124]. He et al [125] reported that sodium restriction was associated with significant reduction in cardiovascular events but not in mortality.…”
Section: Hypertension and Kidney Diseases Update 2011mentioning
confidence: 99%