Reduced Cortical Thickness of Brain Areas Involved in Pain Processing in Patients With Chronic Pancreatitis

Frøkjær, Jens Brøndum; Bouwense, Stefan; Olesen, Søren Schou; Lundager, Flemming Holbæk; Eskildsen, Simon Fristed; Goor, Harry van; Wilder–Smith, Oliver H.G.; Drewes, Asbjørn Mohr

doi:10.1016/j.cgh.2011.11.024

Cited by 71 publications

(33 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This increased sensitivity may reflect changes in central neuronal pathways of the spinal cord and brain (47, 48). Brain MRI studies show alteration in brain thickness and microstructure in cingulate and prefrontal cortices correlating to CP patients' clinical pain scores (49, 50), reminiscent of changes seen in patients that suffer from other chronic pain states (e.g. lower back pain) (51).…”

Section: Resultsmentioning

confidence: 99%

Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group

et al. 2016

View full text Add to dashboard Cite

Description Pain in patients with chronic pancreatitis (CP) remains the primary clinical complaint and source of poor quality of life. However, clear guidance on evaluation and treatment is lacking. Methods Pancreatic Pain working groups reviewed information on pain mechanisms, clinical pain assessment and pain treatment in CP. Levels of evidence were assigned using the Oxford system, and consensus was based on GRADE. A consensus meeting was held during PancreasFest 2012 with substantial post-meeting discussion, debate, and manuscript refinement. Results Twelve discussion questions and proposed guidance statements were presented. Conference participates concluded: Disease Mechanism: Pain etiology is multifactorial, but data are lacking to effectively link symptoms with pathologic feature and molecular subtypes. Assessment of Pain: Pain should be assessed at each clinical visit, but evidence to support an optimal approach to assessing pain character, frequency and severity is lacking. Management: There was general agreement on the roles for endoscopic and surgical therapies, but less agreement on optimal patient selection for medical, psychological, endoscopic, surgical and other therapies. Conclusions Progress is occurring in pain biology and treatment options, but pain in patients with CP remains a major problem that is inadequately understood, measured and managed. The growing body of information needs to be translated into more effective clinical care.

show abstract

Section: Resultsmentioning

confidence: 99%

Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Functionally, the MCC, hypothalamus and PAG form a descending pain modulatory system, through which some supraspinal areas can directly or indirectly regulate the processing of nociceptive stimuli on the dorsal horn of the spinal cord. MCC dysfunction may indicate damages to the endogenous pain suppressing system [17]. The insula and MCC dysfunctions suppress the reaction of the cingulated gyrus-PAG/brainstem descending inhibitory system and the receptive system in the anterior insula to nociceptive stimuli, thereby inhibiting the normal analgesic effect of the body [15].…”

Section: Discussionmentioning

confidence: 99%

Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging

Bao

Liu

et al. 2016

Pain

View full text Add to dashboard Cite

Abnormal pain processing in the central nervous system may be related to abdominal pain in patients with Crohn's disease (CD). The purpose of this study was to investigate changes in resting-state brain activity in CD patients in remission and its relationship with the presence of abdominal pain. Twenty-five CD patients with abdominal pain, 25 CD patients without abdominal pain, and 32 healthy subjects were scanned using a 3.0 T functional magnetic resonance imaging (fMRI) scanner. Regional homogeneity (ReHo) was used to assess resting-state brain activity. Daily pain scores were collected 1 week before fMRI scanning. We found that patients with abdominal pain exhibited lower ReHo values in the insula, middle cingulate cortex (MCC), and supplementary motor area, and higher ReHo values in the temporal pole. In contrast, patients without abdominal pain exhibited lower ReHo values in the hippocampal/parahippocampal cortex and higher ReHo values in the dorsomedial prefrontal cortex (all P<0.05, corrected). The ReHo values of the insula and MCC were significantly negatively correlated with daily pain scores for patients with abdominal pain (r=−0.53, P=0.008, and r=−0.61, P=0.002, respectively). These findings suggest that resting-state brain activities are different between remissive CD patients with and without abdominal pain, and that abnormal activities in insula and MCC are closely related to the severity of abdominal pain.

show abstract

“…Гістологічні та нейрофізіологічні дослідження механізму болю показали його зв'язок з нервовим уш-кодженням, що призводить до виникнення вісцеральної гіперчутливості з сенсибіліза-цією центральної нервової системи і реор-ганізацією відділів мозку, які беруть участь в обробці вісцерального болю. Однак механіз-ми, які лежать в основі функціональних та структурних змін, вивчені недостатньо [2,3].…”

Section: вступunclassified

The activity of hyaluronate-binding proteins in the brain and pancreas during experimental chronic pancreatitis in rats

Va¹,

Ov²,

Ушакова³

2014

Fiziol Zh

View full text Add to dashboard Cite

Reduced Cortical Thickness of Brain Areas Involved in Pain Processing in Patients With Chronic Pancreatitis

Cited by 71 publications

References 41 publications

Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group

Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group

Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging

The activity of hyaluronate-binding proteins in the brain and pancreas during experimental chronic pancreatitis in rats

Contact Info

Product

Resources

About