Reduced concentration of serum growth hormone-binding protein in children with idiopathic short stature. National Cooperative Growth Study.

Carlsson, Lena; Attie, Kenneth M.; Compton, Peter; Vitangcol, R. V.; Merimee, Thomas J.

doi:10.1210/jcem.78.6.8200933

Cited by 51 publications

(40 citation statements)

References 21 publications

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“…In line with earlier observations [24–27], average plasma IGF-I is low in ISS and SGA, and the percentage (21%) of low values (<−2.0 SDS) is similar to percentages found previously. Remarkably, average plasma IGFBP-3 levels are normal.…”

Section: Discussionsupporting

confidence: 92%

The Auxological and Biochemical Continuum of Short Children Born Small for Gestational Age (SGA) or with Normal Birth Size (Idiopathic Short Stature)

Caliebe

Martin

Ranke

et al. 2010

International Journal of Pediatric Endocrinology

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Objective. Retrospective single-centre analysis of growth characteristics in 182 healthy short children born small for gestational age (SGA) or appropriate for gestational age (idiopathic short stature, ISS). Methods. Birth size references from the USA and Sweden were compared, and for the classification as SGA or ISS the Swedish reference was chosen. Height, target height (TH), bone age (BA), predicted adult height (PAH), IGF-I and IGFBP-3 values were compared between SGA and ISS. Results. In the combined group, birth weight and length showed a symmetric Gaussian distribution. The American reference overestimates the percentage of short birth length and underestimates that of low birth weight. In childhood, SGA children were shorter than ISS (−3.1 versus −2.6 SDS, P < .001), also in comparison to TH (−2.6 versus −1.9 SDS, P < .001). TH, height SDS change over time, BA delay, and PAH were similar. IGF-I and IGFBP-3 were lower in ISS (P = .03 and .09). Conclusions. SGA children represent the left tail of the Gaussian distribution of birth size in short children. The distinction between SGA and ISS depends on birth size reference. Childhood height of SGA is lower than of ISS, but the other auxological features are similar.

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Section: Discussionsupporting

confidence: 92%

The Auxological and Biochemical Continuum of Short Children Born Small for Gestational Age (SGA) or with Normal Birth Size (Idiopathic Short Stature)

Caliebe

Martin

Ranke

et al. 2010

International Journal of Pediatric Endocrinology

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“…Causes for CDGP are far from clear. Children with this condition are included, in most studies, in idiopathic short stature, and, whereas normality in the GH secretory dynamics has been reported (22), there are studies that report an impaired GH secretion (23,24), decreased GH binding proteins (25,26) and mutations of the GH receptor in some children with idiopathic short stature (27). Therefore, an abnormality in the GH/IGF-I axis cannot be excluded as a possible factor for the poor mineral density found in CDGP.…”

Section: Journal Of Endocrinology (1998) 139mentioning

confidence: 99%

Bone mineral status in prepubertal children with constitutional delay of growth and puberty

Moreira-Andres¹,

Cañizo²,

Cruz

et al. 1998

European Journal of Endocrinology

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Objective: We wished to clarify whether the osteopenia reported in adult men with a history of constitutional delay of growth and puberty (CDGP) could be due to the delayed puberty or an independent predisposition to osteoporosis in this condition. Design: Short prepubertal children with CDGP and children with familial short stature (FSS) were matched for height and other auxological variables. The FSS children served as a control group. Methods: We measured spinal (L1-L4) bone mineral content (BMC) and bone mineral density (BMD) by dual energy X-ray absorptiometry (Hologic QDR 1000/w) in 56 children aged 5-11 years. All children had height below the 10th percentile for chronological age (CA), and bone age (BA) less than 10 years, 29 of them with clinical diagnosis of possible CDGP and 27 of them with FSS. The BMD standard deviation scores (SDS) relative to the values for normal height children were obtained. Results: The mean (Ϯ S.D.) spinal BMD was significantly lower in the children with CDGP than in the FSS group (0.534 Ϯ 0.059 vs 0.623 Ϯ 0.060 g/cm 2 , P < 0.001). Both groups had negative mean lumbar BMD SDS, but in the CDGP group it was significantly lower than in the FSS group as well when the SDS was based on the CA (¹1.41 Ϯ 0.61 vs ¹0.38 Ϯ 0.51, P < 0.001) and when it was related to BA (¹0.78 Ϯ 0.64 vs ¹0.17 Ϯ 0.52, P < 0.01). BMC was significantly lower in the CDGP than in the FSS group, when multiple regression analysis was performed by using scanned bone area, body weight and height, sex and BA as independent variables (P ¼ 0.0005). Conclusion:The finding of decreased mineralization in prepubertal children with CDGP before the age of puberty suggests that they may have an inherent predisposition to osteopenia.

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“…For example, GHBP concentrations in the blood are positively correlated with the response to GH treatment in children with GHD (3), and there is an inverse relationship between GH secretion and GHBP levels in children of normal height (9). In GH-'sufficient' children with idiopathic short stature, GHBP levels are low (10), and we recently reported that in adults undergoing abdominal surgery both mRNA levels for the GH receptor in skeletal muscle and plasma levels of GHBP decrease in parallel (8). Studies of the regulation of GHBP may therefore indirectly provide information about the regulation of the GH receptor.…”

Section: Introductionmentioning

confidence: 99%

Leptin levels are strongly correlated with those of GH-binding protein in prepubertal children

Bjarnason

Boguszewski

Dahlgren

et al. 1997

European Journal of Endocrinology

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Objective: Nutritional status is an important determinant of growth, and previous studies have indicated that this is due, at least in part, to an increased target-tissue sensitivity to GH. An attractive candidate for mediating this effect is leptin, a hormone secreted by the adipose tissue. The aim of this study was to investigate if there was a connection between GH-binding protein (GHBP) and leptin. Design and Methods: We investigated the relationship between serum levels of leptin and those of GHBP in 229 prepubertal children. These included 107 healthy children with normal GH secretion, 55 GHdeficient (GHD) children and 55 children born small for gestational age (SGA) sampled on one occasion for GHBP and leptin, and 12 healthy children followed longitudinally at monthly intervals for 1 year. Results: In the healthy children and in those born SGA, the serum concentration of GHBP was positively correlated with that of leptin (r ¼ 0:65, P < 0:001; r ¼ 0:74, P < 0:001 respectively). There was no correlation between GHBP and leptin in the group of children with GHD (r ¼ 0:27, not significant). This means that leptin alone explained 42% of the variation of GHBP in the healthy group and 55% in the SGA group. The correlation remained after adjustment for body mass index and age in the healthy children (r ¼ 0:57, P < 0:0001, r 2 ¼ 0:33) and for children born SGA (r ¼ 0:74, P < 0:0001, r 2 ¼ 0:55). There was a positive correlation between the intra-individual monthly changes in GHBP and changes in leptin respectively, in the 12 healthy children followed longitudinally, the mean of the correlation coefficients was 0:38 (median ¼ 0:29; range 0:03 to 0:86; P < 0:05). Conclusions: There was a highly significant correlation between serum levels of leptin and those of GHBP, except in children with GHD. The possibility that leptin could mediate the effects of body fat mass on GH sensitivity, therefore, merits further investigation. European Journal of Endocrinology 137 68-73

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Reduced concentration of serum growth hormone-binding protein in children with idiopathic short stature. National Cooperative Growth Study.

Cited by 51 publications

References 21 publications

The Auxological and Biochemical Continuum of Short Children Born Small for Gestational Age (SGA) or with Normal Birth Size (Idiopathic Short Stature)

The Auxological and Biochemical Continuum of Short Children Born Small for Gestational Age (SGA) or with Normal Birth Size (Idiopathic Short Stature)

Bone mineral status in prepubertal children with constitutional delay of growth and puberty

Leptin levels are strongly correlated with those of GH-binding protein in prepubertal children

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