Reduced cognitive function contributes to economic burden of multiple sclerosis

Maltby, Vicki E.; Lea, Rodney Arthur; Penny, Reeves; Saugbjerg, Bente; Lechner‐Scott, Jeannette

doi:10.1016/j.msard.2022.103707

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…It has a marked effect on the instrumental activities of daily living, additional to the impact of physical impairments. This is reflected in the finding that impairments in several cognitive domains each relate to the economic burden of care, independent from physical disability (Maltby et al, 2022).…”

Section: Ms Cognitionmentioning

confidence: 99%

What would improve MS clinic services for cognition? – A stakeholder panel and survey exploration

Langdon

Coutts

McGuigan

et al. 2022

Multiple Sclerosis and Related Disorders

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Section: Ms Cognitionmentioning

confidence: 99%

What would improve MS clinic services for cognition? – A stakeholder panel and survey exploration

Langdon

Coutts

McGuigan

et al. 2022

Multiple Sclerosis and Related Disorders

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“…To this end, we employed three animal models of ADs, namely CIA in rats [ 24 ], a MOG 35–55 -induced EAE in mice [ 10 ], and a ConA-induced hepatitis in mice [ 20 ]. ADs, such as RA or MS, represent a growing economic burden for societies around the world and have a profound negative impact on the health-related quality of life of people suffering from these diseases [ 32 ]. Current treatment strategies of ADs aim at induction of remission when the disease is not active, and its maintaining or minimization of the disease activity.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases

et al. 2022

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Current treatment strategies of autoimmune diseases (ADs) display a limited efficacy and cause numerous adverse effects. Phosphodiesterase (PDE)4 and PDE7 inhibitors have been studied recently as a potential treatment of a variety of ADs. In this study, a PK/PD disease progression modeling approach was employed to evaluate effects of a new theophylline derivative, compound 34, being a strong PDE4 and PDE7 inhibitor. Activity of the studied compound against PDE1 and PDE3 in vitro was investigated. Animal models of multiple sclerosis (MS), rheumatoid arthritis (RA), and autoimmune hepatitis were utilized to assess the efficacy of this compound, and its pharmacokinetics was investigated in mice and rats. A new PK/PD disease progression model of compound 34 was developed that satisfactorily predicted the clinical score-time courses in mice with experimental encephalomyelitis that is an animal model of MS. Compound 34 displayed a high efficacy in all three animal models of ADs. Simultaneous inhibition of PDE types located in immune cells may constitute an alternative treatment strategy of ADs. The PK/PD encephalomyelitis and arthritis progression models presented in this study may be used in future preclinical research, and, upon modifications, may enable translation of the results of preclinical investigations into the clinical settings.

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“… 1 In terms of productivity changes, 60 hours could be lost over three months due to MS. 2 Aside from the probable physical disabilities, the cognitive aspects could also pose a substantial burden to the patients, their close ones, and the society. 3 …”

Section: Introductionmentioning

confidence: 99%

Economic and Social Standing of Individuals in Iran Diagnosed with Multiple Sclerosis

Ghadiri,

Sahraian,

Ashtari

et al. 2023

Arch Iran Med

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Background: Multiple sclerosis (MS) may be affected by socioeconomic status (SES). This study aims to explore the determinants of SES among Iranian patients with MS and examine how these factors relate to disability and disease progression. Methods: All patients with MS listed in the nationwide MS registry of Iran (NMSRI) until January 8, 2022, were included in this population-based study. Results: Among the 5153 patients, most were female (74.5%), married (70.8%), and did not hold an academic degree (53.8%). Unemployment (OR: 3.75) and being unmarried (OR: 2.60) were significantly associated with Expanded Disability Status Scale (EDSS)≥6, and the time to progression was shorter in the unemployed group (P value: 0.03). There was also a significant negative correlation between the time to progression and the age at disease onset. Conclusion: The study suggests that providing financial and social support to MS patients and their families through investment could reduce both individual and societal burdens.

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Reduced cognitive function contributes to economic burden of multiple sclerosis

Cited by 12 publications

References 28 publications

What would improve MS clinic services for cognition? – A stakeholder panel and survey exploration

What would improve MS clinic services for cognition? – A stakeholder panel and survey exploration

Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases

Economic and Social Standing of Individuals in Iran Diagnosed with Multiple Sclerosis

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