Reduced cognitive ability in alcohol dependence: Examining the role of covarying externalizing psychopathology.

Finn, Peter R.; Rickert, Martin E.; Miller, Melissa A.; Lucas, Jesolyn; Bogg, Tim; Bobova, Lyuba; Cantrell, Hope

doi:10.1037/a0014656

Cited by 54 publications

(107 citation statements)

References 96 publications

(152 reference statements)

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…The fi ndings suggest neural activation as potential biomarkers for youth at risk to transition to heavy drinking. Diminished executive cognitive abilities in working memory may contribute signifi cantly to the development and maintenance of alcohol use disorders (Finn, 2002;Finn et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Any defi cits in working memory from heavy drinking would have a substantial negative effect on normal daily functioning of adolescents. Less effi cient working memory and attention could deter heavy-drinking adolescents from academic and occupational success and predispose them to alcohol use disorders (Finn et al, 2009). Future directions for this work are to (a) replicate these fi ndings in a larger sample; (b) disseminate fi ndings through adolescent drinking-prevention materials and public service campaigns; and (c) inform intervention and psychoeducational programs on how to optimally intervene with youth engaging in heavy drinking, considering brain response and neurocognitive patterns linked to adolescent alcohol use.…”

Section: Discussionmentioning

confidence: 99%

“…Any defi cits in working memory accrued from heavy drinking would have substantial negative effects on daily functioning. Second, working-memory capacity has an important infl uence on decision making and may moderate risk for heavy alcohol use (Finn, 2002;Finn et al, 2009). Third, working memory continues to improve over the course of adolescence to early adulthood, with greater reliance on the more refi ned and effi cient use of right dorsolateral prefrontal and bilateral parietal cortex during task performance (Crone et al, 2006).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Brain Response to Working Memory Over Three Years of Adolescence: Influence of Initiating Heavy Drinking

Squeglia

Pulido

Wetherill

et al. 2012

J. Stud. Alcohol Drugs

139

136

View full text Add to dashboard Cite

ABSTRACT. Objective: Many adolescents engage in heavy alcohol use. The aim of this study was to disentangle whether brain abnormalities seen in adolescent heavy drinkers are a consequence of heavy drinking, a preexisting risk factor for initiation of alcohol use, or both. Method: Study 1 used cross-sectional functional magnetic resonance imaging (fMRI) visual working-memory (VWM) data from 15-to 19-year-olds (20 heavy drinkers, 20 controls) to identify brain regions affected by heavy adolescent alcohol use. Study 2 used longitudinal fMRI VWM data from 12-to 16-year-olds imaged before the onset of drinking and imaged again on the same scanner approximately 3 years later. Those who had transitioned into heavy drinking (n = 20) were matched to continuous nondrinkers (n = 20) on baseline alcohol risk and developmental factors (N = 40; 80 scans). Results: Study 1 found that heavy drinkers exhibited more frontal and parietal but less occipital activation than controls, defi ning the regions of interest for Study 2. In Study 2, adolescents who later transitioned into heavy drinking showed less fMRI response contrast at baseline than continuous nondrinkers, which increased after the onset of heavy drinking, in frontal (1,431 µL, p = .003; η 2 = .19) and parietal (810 µL, p = .005; η 2 = .23) regions, as in Study 1. Lower baseline activation in the frontal and parietal regions predicted subsequent substance use, more so than commonly observed predictors of youth drinking (p < .05). Conclusions: Adolescents who initiated heavy drinking showed different brain activation before the onset of drinking, then less effi cient information processing after high-dose alcohol use started. This suggests neural response patterns that could be risk factors for future substance use and also supports prior neuropsychological reports indicating that initiating heavy episodic drinking in adolescence may be followed by subtle alterations in brain functioning. (J. Stud. Alcohol Drugs, 73, 749-760, 2012)

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Brain Response to Working Memory Over Three Years of Adolescence: Influence of Initiating Heavy Drinking

Squeglia

Pulido

Wetherill

et al. 2012

J. Stud. Alcohol Drugs

139

136

View full text Add to dashboard Cite

show abstract

“…This is not surprising, since working memory is believed to represent a supervisory control system that monitors cognition and self-regulatory behavior (Burgess et al 2007;Endres et al 2011;Koechlin et al 1999;Miller 2000). In addition, there is evidence suggesting that working memory is associated with indicators of impulsive/sensation-seeking behavior and antisocial/unconventional personality traits (Bogg and Finn 2010;Finn et al 2009). It seems that working memory is an overarching concept, which might underlie different aspects of antisocial behavior and differentiates antisocial from normal behavior.…”

Section: The Selection Of Neuropsychological Tasksmentioning

confidence: 99%

Using basic neurobiological measures in criminological research

Cornet

2015

Crime Sci

View full text Add to dashboard Cite

Research on the relationship between neurobiological factors and antisocial behavior has grown exponentially in recent decades. As a result, criminal behavior has been related to impairments in different biological systems, such as genetics, hormones and brain functioning. The development of innovative techniques, for example brain imaging techniques and physiological measurements, can partially explain the increase in neurobiological studies on criminal behavior. Despite a recent zeitgeist change, which has led to a greater acceptance of neurobiology as an additional approach for the study of criminal behavior, neurobiological measurements dot not yet play a more significant role in criminological research and practice. This article aims to familiarize crime researchers and other interested readers with two important neurobiological measures, namely neuropsychological assessment and resting heart rate measurement, and with how these measures can play an important role in criminological research. It will argue that neuroscientific approaches might benefit the field of criminology in several important ways, from assessing the empirical validity of criminological theories to improving the effectiveness of correctional intervention programs. Furthermore, this article will provide insight into how to use these measures in research, to guide interested readers towards their application in their own studies.

show abstract

“…While the direct treatment implications are not clear, it is important to note that the emerging work in physiology indicates that substance abuse and disinhibition are different [66]. Prominent striatal dopamine has an important influence on externalizing proneness (disinhibition) and on reward-based decision-making.…”

Section: Contributions From Contemporary Pharmacology and Neurosciencementioning

confidence: 99%

Substance Abuse Therapeutics

Mills¹

2016

Recent Advances in Drug Addiction Research and Clinical Applications

View full text Add to dashboard Cite

This chapter provides a broad overview of therapies for substance abuse. These therapies are understood in the context of the history of drug use in the United States and factors that influenced the expansion and regulation of substance use. This is followed by a discussion of how the complexity of these factors was associated with difficulties in understanding substance misuse and created challenges to the creation of effective treatment systems. The chapter reviews the moral and disease models of addiction before discussing the diagnosis of substance-related disorders. The chapter describes major treatment approaches and their efficacy.

show abstract

Reduced cognitive ability in alcohol dependence: Examining the role of covarying externalizing psychopathology.

Cited by 54 publications

References 96 publications

Brain Response to Working Memory Over Three Years of Adolescence: Influence of Initiating Heavy Drinking

Brain Response to Working Memory Over Three Years of Adolescence: Influence of Initiating Heavy Drinking

Using basic neurobiological measures in criminological research

Substance Abuse Therapeutics

Contact Info

Product

Resources

About