Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth

Abstract

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The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles

“…As a first step toward such applications, we demonstrated that the dissociated FC profiles of the identified CBF subdivisions are reproducible in rs‐fMRI acquisitions of elderly participants as typically collected in clinical research settings. We expect rs‐fMRI‐based assessments of CBF connectivity to be particularly useful for the study of functional CBF alterations in predementia stages of neurodegenerative disease (Brayda‐Bruno et al, ; Grothe, Ewers, Krause, Heinsen, & Teipel, ; Lim et al, ; Ray et al, ), as well as other neuropsychiatric conditions with cholinergic involvement that are not typically associated with gross neurodegeneration (Grothe et al, ; Perry et al, ; Sarter et al, ).…”

A machine learning investigation of volumetric and functional MRI abnormalities in adults born preterm

“…Of the initial 682 infants born VP/VLBW, 411 were eligible for the 26-year follow-up assessment, and 260 (63.3%) participated in psychological assessments (Breeman, Jaekel, Baumann, Bartmann, & Wolke, 2015). Previous research using subsets of this sample has been published Daamen et al, 2014;Daamen et al, 2015;Grothe et al, 2017;Jurcoane et al, 2015;Meng et al, 2015;Shang et al, 2018). Of these, 308 were eligible for the 26-year follow-up assessment, and 229 (74.4%) participated in psychological assessments.…”

“…For example, a common hypothesis is that periventricular white matter injury impacts the development of premyelinating oligodendrocytes and subplate neurons resulting in an impaired development of thalamo-cortical connectivity (Grothe et al, 2017;Hoerder-Suabedissen & Molnar, 2015;Thompson et al, 2014), which then leads to the reduced thalamus gray matter volume (GMV) and related widely distributed white matter changes seen in adulthood Joseph J. Volpe, 2009). For example, a common hypothesis is that periventricular white matter injury impacts the development of premyelinating oligodendrocytes and subplate neurons resulting in an impaired development of thalamo-cortical connectivity (Grothe et al, 2017;Hoerder-Suabedissen & Molnar, 2015;Thompson et al, 2014), which then leads to the reduced thalamus gray matter volume (GMV) and related widely distributed white matter changes seen in adulthood Joseph J. Volpe, 2009).…”

“…Until recently, research has predominantly used mass-univariate testing to make downstream inferences regarding pathological signatures of preterm birth in adolescents and adults. For example, a common hypothesis is that periventricular white matter injury impacts the development of premyelinating oligodendrocytes and subplate neurons resulting in an impaired development of thalamo-cortical connectivity (Grothe et al, 2017;Hoerder-Suabedissen & Molnar, 2015;Thompson et al, 2014), which then leads to the reduced thalamus gray matter volume (GMV) and related widely distributed white matter changes seen in adulthood Joseph J. Volpe, 2009). Structural damage and downstream abnormalities are also thought to be linked to functional changes, as evident in univariate task-based and resting-state MRI studies (Baldoli et al, 2015;Bauml et al, 2014;Froudist-Walsh et al, 2015;Meng et al, 2015;Shang et al, 2018).…”

Cognitive Deficits in Prematurely Born Adults Are Associated With Reduced Basal Forebrain Integrity

“…In this issue, Grothe et al (1) investigate whether the impairments in the development of the cholinergic basal forebrain (cBF) contributes to cognitive deficits in premature born individuals during adulthood.…”