Reduced cardiac parasympathetic activity in children with autism

Ming, Xue; Julu, Peter O.O.; Brimacombe, Michael; Connor, Susan; Daniels, M. Leigh Anne

doi:10.1016/j.braindev.2005.01.003

Cited by 204 publications

(202 citation statements)

References 24 publications

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“…Some of these manifestations, including unexplained constipation or diarrhea, urinary retention, cold and clammy extremities, and sleep disturbances, suggest underlying autonomic dysfunction. 97 These children seem to have impaired parasympathetic activity resulting in unrestrained sympathetic activity. 97 Autonomic tests have demonstrated blunted autonomic arousal responses to visual and auditory social stimuli.…”

Section: Autismmentioning

confidence: 99%

“…97 These children seem to have impaired parasympathetic activity resulting in unrestrained sympathetic activity. 97 Autonomic tests have demonstrated blunted autonomic arousal responses to visual and auditory social stimuli. 98,99 In addition, there is low baseline cardiac vagal tone and low cardiac baroreceptor sensitivity, resulting in hyperactive heart rate and blood pressure responses.…”

Section: Autismmentioning

confidence: 99%

“…98,99 In addition, there is low baseline cardiac vagal tone and low cardiac baroreceptor sensitivity, resulting in hyperactive heart rate and blood pressure responses. 97 However, paradoxically, children with autistic behavior are less flexible in their autonomic adaptation to attention-demanding tasks and demonstrate less decrease in heart rate variability than normal controls during periods of task performance. 97 In support of central autonomic dysfunction, pathologic examinations have revealed abnormalities in central structures often associated with autonomic control, such as the brainstem, the amygdala, the limbic system, the cerebellum, and the prefrontal lobes.…”

Section: Autismmentioning

confidence: 99%

“…97 However, paradoxically, children with autistic behavior are less flexible in their autonomic adaptation to attention-demanding tasks and demonstrate less decrease in heart rate variability than normal controls during periods of task performance. 97 In support of central autonomic dysfunction, pathologic examinations have revealed abnormalities in central structures often associated with autonomic control, such as the brainstem, the amygdala, the limbic system, the cerebellum, and the prefrontal lobes. 100 In addition, abnormal levels of monoaminergic and cholinergic neurotransmitters, including norepinephrine, dopamine, acetylcholine, serotonin, and various neuropeptides, have been reported.…”

Section: Autismmentioning

confidence: 99%

“…100 In addition, abnormal levels of monoaminergic and cholinergic neurotransmitters, including norepinephrine, dopamine, acetylcholine, serotonin, and various neuropeptides, have been reported. 97 In addition, secretin and oxytocin, both polypeptide neurotransmitters that cross the blood-brain barrier, have each been reported to improve some of the symptoms in different autistic subgroups. 101,102 The reversal of symptoms through agents that seem to alter central autonomic function further supports direct involvement of autonomic centers in autism.…”

Section: Autismmentioning

confidence: 99%

See 4 more Smart Citations

Pediatric Autonomic Disorders

2006

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The scope of pediatric autonomic disorders is not well recognized. The goal of this review is to increase awareness of the expanding spectrum of pediatric autonomic disorders by providing an overview of the autonomic nervous system, including the roles of its various components and its pervasive influence, as well as its intimate relationship with sensory function. To illustrate further the breadth and complexities of autonomic dysfunction, some pediatric disorders are described, concentrating on those that present at birth or appear in early childhood.www.pediatrics.org/cgi

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Section: Autismmentioning

confidence: 99%

Section: Autismmentioning

confidence: 99%

Section: Autismmentioning

confidence: 99%

Section: Autismmentioning

confidence: 99%

Section: Autismmentioning

confidence: 99%

See 3 more Smart Citations

Pediatric Autonomic Disorders

2006

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Sensory Features in Autism Spectrum Disorders

Baranek

Little

Parham

et al. 2014

Handbook of Autism and Pervasive Developmental Disorders, Fourth Edition

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Sensory features (i.e., unusual behavioral responses to sensory stimuli) are highly prevalent and heterogeneous across individuals with ASD. From a developmental perspective, sensory response patterns are associated with and have cascading effects on other core symptoms in ASD. Burgeoning research using novel technologies is beginning to uncover the nature and pathogenesis of these features. As sensory issues often demonstrate a functional impact on adaptive behavior, social participation, and well‐being, it is important that the evidence base for clinical interventions continues to grow.

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Children with Autism Show Altered Autonomic Adaptation to Novel and Familiar Social Partners

2015

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Social deficits are fundamental to autism spectrum disorder (ASD), and a growing body of research implicates altered functioning of the autonomic nervous system (ANS), including both sympathetic and parasympathetic branches. However, few studies have explored both branches concurrently in ASD, particularly within the context of social interaction. The current study investigates patterns of change in indices of sympathetic (pre-ejection period; PEP) and parasympathetic (respiratory sinus arrhythmia; RSA) cardiac influence as boys (ages 8-11 years) with (N = 18) and without (N = 18) ASD engage in dyadic social interaction with novel and familiar social partners. Groups showed similar patterns of autonomic change during interaction with the novel partner, but differed in heart rate, PEP, and RSA reactivity while interacting with a familiar partner. Boys without ASD evinced decreasing sympathetic and increasing parasympathetic influence, whereas boys with ASD increased in sympathetic influence. Boys without ASD also demonstrated more consistent ANS responses across partners than those with ASD, with parasympathetic responding differentiating familiar and novel interaction partners. Finally, PEP slopes with a familiar partner correlated with boys' social skills. Implications include the importance of considering autonomic state during clinical assessment and treatment, and the potential value of regulation strategies as a complement to intervention programs aiming to support social cognition and behavior. Autism Res 2016, 9: 579-591. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

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Reduced cardiac parasympathetic activity in children with autism

Cited by 204 publications

References 24 publications

Pediatric Autonomic Disorders

Pediatric Autonomic Disorders

Sensory Features in Autism Spectrum Disorders

Children with Autism Show Altered Autonomic Adaptation to Novel and Familiar Social Partners

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