Reduced bone density in individuals with severe hemophilia B

Mansouritorghabeh, Hassan; Rezaieyazdi, Zahra; Saadati, Nayyereh; Saghafi, Masoud; Mirfeizi, Zahra; Rezai, J.

doi:10.1111/j.1756-185x.2009.01394.x

Cited by 25 publications

(42 citation statements)

References 15 publications

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“…Hemophilia B is seen as 1 case among 5,000 male births in the European countries and United State. [ 3 ] It is estimated that the total number of hemophilia to be about 500,000 in the universe. [ 4 ] Among 77 countries in the world, the total number of individuals with hemophilia has been estimated 100,000.…”

Section: Common Bleeding Disorders: Hemophiliamentioning

confidence: 99%

“…This confirmed by further surveys on individuals with hemophilia. [ 3 39 40 41 42 43 44 ] After that reduced bone density has been shown in two other bleeding disorders (hemophilia B and combined factor V and VIII deficiency). [ 3 44 45 ] There are gaps in status of bone density in vWD, factor VII deficiency, factor V deficiency, factor X deficiency, factor XIII deficiency, fibrinogen abnormalities, and platelet disorders.…”

Section: The New Horizon For Further Surveysmentioning

confidence: 99%

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Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Mansouritorghabeh

Rezaieyazdi

2017

J Bone Metab

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Bleeding disorders, including hemophilia, can be seen in every ethnic population in the world. Among various bleeding disorders, reduced bone density has been addressed in hemophilia A. In recent years, there has been an increasing interest in addressing osteopenia and osteoporosis in hemophilia A. There is little or no study about the possible susceptibility of other individuals with bleeding disorders to reduced bone density. Questions have been raised about the role of blood coagulation factors in bone mineralization. This review provides new insight and ideas for further survey in the field of bleeding disorders and reduced bone density.

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Section: Common Bleeding Disorders: Hemophiliamentioning

confidence: 99%

Section: The New Horizon For Further Surveysmentioning

confidence: 99%

Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Mansouritorghabeh

Rezaieyazdi

2017

J Bone Metab

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“…Barnes et al (13) compared BMImatched PWH and normal healthy controls and showed significantly reduced BMD in PWH. Mansouritorghabeh et al (14) showed that BMD is significantly reduced even in cases of severe haemophilia B and the effect on BMD is not dependent on the severity of haemophilia (13,14). PWH with low BMD have reduced bone formation activity, while no difference was found with regard to bone resorption markers (15).…”

Section: Osteoporosis and Osteopenia In Persons With Haemophiliamentioning

confidence: 99%

“…Several studies have published increased prevalence of decreased BMD amongst PWH (6,(11)(12)(13)(14)(15)(16)(17)(18)(19). The prevalence of osteopenia and osteoporosis has been variable in these studies.…”

Section: Osteoporosis and Osteopenia In Persons With Haemophiliamentioning

confidence: 99%

Bone health in persons with haemophilia: a review

Ghosh

Shetty

2012

European J of Haematology

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Bone density is a measure of equilibrium between bone formation and bone resorption; any imbalance in these two processes might lead to osteopenia and osteoporosis. Osteoporosis in general has been considered to be an important cause of morbidity in both men and women and more so in haemophilia and other bleeding disorders. Specific triggering factors in persons with haemophilia (PWH) are abnormal liver function because of viral infection, bleeding and inflammation, lack of physical and athletic activities, low body weight and others. Although the pathogenesis of osteoporosis is not clear, it has been considered as a severe comorbidity in PWH in both developing and developed countries. This is more evident in developing countries where there is no free access to factor concentrates, and primary prophylaxis is beyond the reach of vast majority of the patients. Only few references are available in the literature on the prevalence and management of osteoporosis in haemophilia population. This review summarises the prevalence, plausible mechanisms and management options of this important morbidity in PWH.

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“…Nowadays, long-term survival of individuals with haemophilia has been improved noticeably that attributable to many factors including improved treatment regimens, but new concerns such as inhibitor autoantibody to coagulation factors and RBD have been emerged recently [10,11]. We also need new insights into the pathophysiology and also management of reduced bone density in bleeding disorders.…”

Section: Introductionmentioning

confidence: 96%

Bleeding disorders and reduced bone density

Mansouritorghabeh

Rezaieyazdi

2010

Rheumatol Int

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In recent decays, quality of life and life expectancy of individuals with severe haemophilia A and B have been improved by better quality in treatment and more availability of blood coagulation products. Recently, new concerns have emerged in current groups such as auto-antibody inhibitors to coagulation factors and reduced bone density (RBD). RBD in bleeding disorders is becoming an escalating burden worldwide due to an increased in life expectancy and also in the ageing population with bleeding disorders. Here, we review published papers on bone mineral density of individuals with haemophilia A & B, a rare bleeding disorder entitled combined factor V and VIII deficiency and other rare bleeding disorders. It seems in individuals with bleeding disorders preventive measures including early detection, treatment and adequate physical activity, encouragement to be active in sports and finally anti-osteoporotic therapy must be done.

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Reduced bone density in individuals with severe hemophilia B

Abstract: The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.

Cited by 25 publications

References 15 publications

Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Bone health in persons with haemophilia: a review

Bleeding disorders and reduced bone density

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