Reduced binding of (3H)-1,25-Dihydroxyvitamin D3 in peripheral blood mononuclear cells from patients with chronic renal failure

Martinez, Juliana; Olmos, JM; Francisco, Alm de; Riancho, J A; Ja, Amado; González‐Macías, Jesús

doi:10.1016/0169-6009(92)91852-a

Cited by 2 publications

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“…In addition, a lower number of l,25(OH)2D vitamin receptors in target cells from pa tients with hyperparathyroidism secondary to chronic renal failure has been reported [13], According to these considerations, one should expect that the lower TSH response to TRH in dialysis patients with hyperparathy roidism is due to a low concentration or decreased sensi tivity of thyrotrophs to the secosteroid. On the other hand, the enhancement of the TSH secretory reserve after PTX might be explained by the postoperative treatment with vitamin l,25(OH)2D.…”

Section: Discussionmentioning

confidence: 99%

Effect of Parathyroidectomy on Thyrotropic and Lactotropic Function in Patients with Renal Osteopathy

Žofková

Sotorník²

1995

Nephron

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To test the effect of parathyroidectomy on thyrotropic and lactotropic function, a thyrotropin-releasing hormone (TRH) test was performed before and between the 2nd and 3rd month after operation in 13 haemodialysed patients with secondary hyperparathyroidism. The thyrotropin response to TRH was higher in the postoperative period as compared with the values before the operation (p < 0.01). The prolactin response to TRH did not differ from the values before the operation. No correlations between thyrotropin response and serum parathyroid hormone (PTH), ionised calcium and haemoglobin or haematocrit were found. The lower sensitivity of the thyrotropic system to TRH in patients with renal osteopathy is not dependent on serum PTH or calcium.

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Section: Discussionmentioning

confidence: 99%