Reduced Auditory Steady State Responses in Autism Spectrum Disorder

Goiaeva

et al. 2020

Preprint

Background: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorders (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the Auditory Steady State Response (ASSR) and the Sustained Field (SF). It has been shown that the SF in neuro-typical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, this auditory response may reflect vocal pitch processing abnormalities in ASD. The SF, however, has never been studied in people with these disorders. Methods: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in 7-13-year-old boys with ASD (N=35) and neuro-typical (NT) boys (N=35). Results: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher contralaterally to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF did not change between 7 and 13 years. It was moderately decreased in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. Limitations: We have not tested language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. Conclusion: The selective left-hemispheric SF abnormalities found in children with ASD are consistent with a deficit at a low level of pitch processing, which in turn may contribute to their difficulties in perception and production of linguistic prosody.

Section: Assr In Nt Children and Children With Asdmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Left Hemispheric Deficit in the Sustained Neuromagnetic Response to Periodic Click Trains in Children with ASD.

Goiaeva

et al. 2020

Preprint

Section: Introductionmentioning

confidence: 98%

“…Although both the SF and ASSR were previously associated with processing of periodicity/temporal regularity [19,21], only the 40 Hz ASSR has been examined in individuals with ASD [22][23][24][25]. The ASSR is an oscillatory response phase-locked to the onset of each single auditory event, i.e.…”

Section: Introductionmentioning

confidence: 99%

Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD

Goiaeva

et al. 2020

Preprint

Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorders (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the Auditory Steady State Response (ASSR) and the Sustained Field (SF). It has been shown that the SF in neuro-typical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, this auditory response may reflect vocal pitch processing abnormalities in ASD. The SF, however, has never been studied in people with these disorders. We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in 7-13-year-old boys with ASD (N=35) and neuro-typical (NT) boys (N=35). In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and the right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher contralaterally to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF was moderately decreased in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. We suggest that the selective left-hemispheric SF abnormalities in children with ASD reflect a low-level deficiency in pitch processing that may contribute to their difficulties with perception and production of linguistic prosody.

“…Although both the SF and ASSR had been previously associated with processing of periodicity/temporal regularity [19,21], only the ASSR has been examined in individuals with ASD [22][23][24][25]. The ASSR is an oscillatory response phase-locked to the onset of each single auditory event, i.e.…”

Section: Introductionmentioning

confidence: 99%

Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD.

Sysoeva

et al. 2020

Preprint

Background: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, this auditory response may reflect vocal pitch processing abnormalities in ASD. The SF, however, has never been studied in people with this disorder. Methods: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N=35) and neurotypical (NT) boys (N=35) aged 7-12-years.Results: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms.Limitations: We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative.Conclusion: Children with ASD demonstrate selective left-hemispheric abnormalities at the level of the core auditory cortex when processing spectrally complex periodic sound. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody.