Reduced adipose tissue in growth-restricted fetuses using quantitative analysis of magnetic resonance images

Rabinowich, Aviad; Avisdris, Netanell; Zilberman, Arkadi; Link-Sourani, Daphna; Lazar, Sapir; Herzlich, Jacky; Specktor-Fadida, Bella; Joskowicz, Leo; Malinger, G.; Ben‐Sira, Liat; Hiersch, Liran; Bashat, Dafna Ben

doi:10.1007/s00330-023-09855-y

Cited by 2 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we previously demonstrated strong agreement among different readers for fetal fat segmentation and good repeatability for automatic fetal volume measurements. 18,27,28 Based on these, our suggested workflow may be adopted by other fetal MRI centers as well.…”

Section: Discussionmentioning

confidence: 99%

“…A detailed description of the computed parameters is given in a previous publication. 18 Those parameters were obtained as follows:…”

Section: Body Composition Analysismentioning

confidence: 99%

“…1. Data on normal TBV development are provided in Specktor-Fadida et al, 27 and data on FBVR and FSF are provided in Rabinowich et al 18…”

Section: Body Composition Analysismentioning

confidence: 99%

“…24 We previously demonstrated that FGR and SGA fetuses had reduced fat signal fraction (FSF) and volume. 18 Against this background, the objective of this study was to investigate the relationship between body and lipid deposition and perinatal outcomes in SGA fetuses, and their performance compared to the common sonography criteria. We hypothesized that leaner and smaller fetuses will experience less favorable perinatal outcomes.…”

mentioning

confidence: 99%

“…Few studies used fetal MRI to characterize normal lipid accretion. 18,23,24 Giza et al showed lipid accretion throughout the third trimester using proton density fat fraction. 23 Similarly, the T 1 -weighted fat signal increased during late gestation.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Fetal MRI‐Based Body and Adiposity Quantification for Small for Gestational Age Perinatal Risk Stratification

Rabinowich,

Avisdris,

Yehuda

et al. 2023

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

BackgroundSmall for gestational age (SGA) fetuses are at risk for perinatal adverse outcomes. Fetal body composition reflects the fetal nutrition status and hold promise as potential prognostic indicator. MRI quantification of fetal anthropometrics may enhance SGA risk stratification.HypothesisSmaller, leaner fetuses are malnourished and will experience unfavorable outcomes.Study TypeProspective.Population40 SGA fetuses, 26 (61.9%) females: 10/40 (25%) had obstetric interventions due to non‐reassuring fetal status (NRFS), and 17/40 (42.5%) experienced adverse neonatal events (CANO). Participants underwent MRI between gestational ages 30 + 2 and 37 + 2.Field Strength/Sequence3‐T, True Fast Imaging with Steady State Free Precession (TruFISP) and T1‐weighted two‐point Dixon (T1W Dixon) sequences.AssessmentTotal body volume (TBV), fat signal fraction (FSF), and the fat‐to‐body volumes ratio (FBVR) were extracted from TruFISP and T1W Dixon images, and computed from automatic fetal body and subcutaneous fat segmentations by deep learning. Subjects were followed until hospital discharge, and obstetric interventions and neonatal adverse events were recorded.Statistical TestsUnivariate and multivariate logistic regressions for the association between TBV, FBVR, and FSF and interventions for NRFS and CANO. Fisher's exact test was used to measure the association between sonographic FGR criteria and perinatal outcomes. Sensitivity, specificity, positive and negative predictive values, and accuracy were calculated. A P‐value <0.05 was considered statistically significant.ResultsFBVR (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.2–0.76) and FSF (OR 0.95, CI 0.91–0.99) were linked with NRFS interventions. Furthermore, TBV (OR 0.69, CI 0.56–0.86) and FSF (OR 0.96, CI 0.93–0.99) were linked to CANO. The FBVR sensitivity/specificity for obstetric interventions was 85.7%/87.5%, and the TBV sensitivity/specificity for CANO was 82.35%/86.4%. The sonographic criteria sensitivity/specificity for obstetric interventions was 100%/33.3% and insignificant for CANO (P = 0.145).Data ConclusionReduced TBV and FBVR may be associated with higher rates of obstetric interventions for NRFS and CANO.Evidence Level2Technical EfficacyStage 5

show abstract

Section: Discussionmentioning

confidence: 99%

“…A detailed description of the computed parameters is given in a previous publication. 18 Those parameters were obtained as follows:…”

Section: Body Composition Analysismentioning

confidence: 99%

“…1. Data on normal TBV development are provided in Specktor-Fadida et al, 27 and data on FBVR and FSF are provided in Rabinowich et al 18…”

Section: Body Composition Analysismentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Fetal MRI‐Based Body and Adiposity Quantification for Small for Gestational Age Perinatal Risk Stratification

Rabinowich,

Avisdris,

Yehuda

et al. 2023

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

Reduced gyrification in fetal growth restriction with prenatal magnetic resonance images

Yehuda,

Rabinowich,

Zilberman

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

Placental-related fetal growth restriction, resulting from placental dysfunction, impacts 3–5% of pregnancies and is linked to elevated risk of adverse neurodevelopmental outcomes. In response, the fetus employs a mechanism known as brain-sparing, redirecting blood flow to the cerebral circuit, for adequate supply to the brain. In this study we aimed to quantitatively evaluate disparities in gyrification and brain volumes among fetal growth restriction, small for gestational age and appropriate-for gestational-age fetuses. Additionally, we compared fetal growth restriction fetuses with and without brain-sparing. The study encompassed 106 fetuses: 35 fetal growth restriction (14 with and 21 without brain-sparing), 8 small for gestational age, and 63 appropriate for gestational age. Gyrification, supratentorial, and infratentorial brain volumes were automatically computed from T2-weighted magnetic resonance images, following semi-automatic brain segmentation. Fetal growth restriction fetuses exhibited significantly reduced gyrification and brain volumes compared to appropriate for gestational age (P < 0.001). Small for gestational age fetuses displayed significantly reduced gyrification (P = 0.038) and smaller supratentorial volume (P < 0.001) compared to appropriate for gestational age. Moreover, fetal growth restriction fetuses with BS demonstrated reduced gyrification compared to those without BS (P = 0.04), with no significant differences observed in brain volumes. These findings demonstrate that brain development is affected in fetuses with fetal growth restriction, more severely than in small for gestational age, and support the concept that vasodilatation of the fetal middle cerebral artery reflects more severe hypoxemia, affecting brain development.

show abstract

Reduced adipose tissue in growth-restricted fetuses using quantitative analysis of magnetic resonance images

Cited by 2 publications

References 39 publications

Fetal MRI‐Based Body and Adiposity Quantification for Small for Gestational Age Perinatal Risk Stratification

Fetal MRI‐Based Body and Adiposity Quantification for Small for Gestational Age Perinatal Risk Stratification

Reduced gyrification in fetal growth restriction with prenatal magnetic resonance images

Contact Info

Product

Resources

About