Reduced activation in the ventral striatum during probabilistic decision-making in patients in an at-risk mental state

Rausch, Franziska; Mier, Daniela; Eifler, Sarah; Fenske, Sabrina; Schirmbeck, Frederike; Englisch, Susanne; Schilling, Cláudia; Meyer‐Lindenberg, Andreas; Kirsch, Peter; Zink, Mathias

doi:10.1503/jpn.140191

Cited by 27 publications

(26 citation statements)

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“…1 We recently found that a schizophrenia RPS was associated with an attenuated VS BOLD response during a probabilistic learning task, 15 suggesting that the cumulative effect of risk single-nucleotide polymorphisms was associated with the VS BOLD alterations previously observed in patients with psychosis [16][17][18] and unaffected relatives. 19 However, it is currently not known whether polygenic risk of psychotic disorders is associated with reward processes, such as anticipation and receipt, as assayed using the monetary incentive delay (MID) task.…”

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confidence: 87%

Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

et al. 2016

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(2016) Polygenic risk of psychosis and ventral striatal activation during reward processing in healthy adolescents. JAMA Psychiatry, 73 (8). pp. 852-861. ISSN 2168-6238 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39607/1/yoi160037.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: http://eprints.nottingham.ac.uk/end_user_agreement.pdf A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.ukCopyright 2016 American Medical Association. All rights reserved. Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy AdolescentsThomas M. Lancaster, PhD; David E. Linden, MD, PhD; Katherine E. Tansey, PhD; Tobias Banaschewski, MD, PhD; Arun L. W. Bokde, PhD; Uli Bromberg, Dipl-Psych; Christian Büchel, MD; Anna Cattrell, PhD; Patricia J. Conrod, PhD; Herta Flor, PhD; Vincent Frouin, PhD; Jürgen Gallinat, MD; Hugh Garavan, PhD; Penny Gowland, PhD; Andreas Heinz, MD, PhD; Bernd Ittermann, PhD; Jean-Luc Martinot, MD, PhD; Marie-Laure Paillère Martinot, MD, PhD; Eric Artiges, MD, PhD; Herve Lemaitre, PhD; Frauke Nees, PhD; Dimitri Papadopoulos Orfanos, PhD; Tomáš Paus, MD, PhD; Luise Poustka, MD; Michael N. Smolka, MD; Nora C. Vetter, PhD; Sarah Jurk, Dipl-Psych; Eva Mennigen, MD; Henrik Walter, MD, PhD; Robert Whelan, PhD; Gunter Schumann, MD; for the IMAGEN Consortium IMPORTANCE Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging.OBJECTIVE To examine whether common risk variants for psychosis are associated with individual variation in the VS. DESIGN, SETTING, AND PARTICIPANTSA cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N = 1524-1836). MAIN OUTCOMES AND MEASURESReward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipatio...

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Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

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“…According to the tripartite model of frontostriatal circuits which are defined by their cortical inputs, the sensorimotor loop connects the somatosensory and motor‐related cortices with the dorsal caudal putamen and dorsal rostral putamen, associative loop connects the dlPFC with the dorsal caudate and ventral rostral putamen, and the limbic loop connects the ACC, OFC, and ventromedial PFC with the VS (including the nucleus accumbens and ventral parts of the caudate and putamen). Among the above loops, limbic and associative loop dysfunction have been reported frequently in patients with SZ or individuals at a high risk for SZ (Juckel et al, ; Lancaster et al, ; Rausch et al, ; Sarpal et al, ; Sole‐Padulles et al, ).…”

Section: Discussionmentioning

confidence: 99%

Functional dysconnectivity of the limbic loop of frontostriatal circuits in first‐episode, treatment‐naive schizophrenia

Lin

Wang

Zhang

et al. 2017

Human Brain Mapping

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Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ-related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first-episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects. Seed-based FC analyses were performed by placing six bilateral pairs of seeds within a priori defined subdivisions of the striatum. We observed significantly decreased FC for the FESZ group relative to the HC group [p < .05, family-wise error (FWE)-corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry. Moreover, bilaterally decreased inferior ventral striatum/nucleus accumbens (VSi)-dorsal anterior cingulate cortex (dACC) FC within the limbic loop correlated inversely with overall FESZ symptom severity and the disorganization factor score of PANSS. These findings provide new insight into the role of frontostriatal limbic loop hypoconnectivity in early-stage schizophrenia pathology and suggest potential novel therapeutic targets.

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“…Currently, few prior studies have reported on the relationship of metamemory biases with early delusions in patients with a FEP or delusional thinking in healthy controls (HCs). Several recent studies also investigated metacognitive functioning in the ARMS and found, for example, jumping to conclusion to be associated with the severity of abnormal beliefs (Broome et al 2007), reduced functional activation in the ventral striatum of ARMS patients during a JTC-fMRI (functional magnetic resonance imaging) task (Rausch et al 2015), or associations between impairments in self-monitoring and delusion ideation (Versmissen et al 2007). In a study with healthy participants, a tendency to rate incorrect memories with higher confidence in those subjects with high delusion ideation scores was found compared to other healthy participants (Laws & Bhatt, 2005).…”

Section: Introductionmentioning

confidence: 99%

Investigation of metamemory functioning in the at-risk mental state for psychosis

et al. 2015

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Reduced activation in the ventral striatum during probabilistic decision-making in patients in an at-risk mental state

Cited by 27 publications

References 52 publications

Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

Functional dysconnectivity of the limbic loop of frontostriatal circuits in first‐episode, treatment‐naive schizophrenia

Investigation of metamemory functioning in the at-risk mental state for psychosis

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