Redução enzimática do 4-(dimetilamino)benzaldeído com pedaços de cenoura (Daucus carota): um experimento simples na compreensão da biocatálise

Cloração Mecanoquímica Da Acetanilida

“…2 Para isto, é necessário o desenvolvimento de experimentos que contemplem, por exemplo, a realização de reação na ausência de solventes 3,4 ou empregando o mais verde deles, a água, 5,6 bem como o uso de biomassa como material de partida/reagente 7 ou aparelhos e técnicas modernas como o uso de micro-ondas, 8 e até mesmo técnicas clássicas modernizadas. Neste último aspecto, a mecanoquímica é a nova fronteira da metodologia sintética.…”

“…9 No desenvolvimento de síntese de substância orgânica como experimento didático inserida no contexto da QV, o emprego da mecanoquímica é ainda relativamente escasso, destacando-se a adição de anilinas a naftoquinonas em fase sólida, como descrito por Martinez e colaboradores. 12 Apesar dos avanços recentes na elaboração de experimentos inseridos num contexto atual, [3][4][5][6][7][8]12 o treinamento prático do profissional da Química na graduação ainda é majoritariamente centrado em reações entre líquidos ou de um líquido com um sólido, sempre mediadas por solvente. A experiência do graduando no emprego de misturas sólidas em química orgânica é restrita à formação de solução sólida de KBr e substâncias orgânicas na obtenção de pastilhas para análise por infravermelho.…”

Biotransformation of Aromatic Ketones by Linum usitatissimum

“…Linum usitatissimum L. (Linaceae), known as flax or linseed, is a good source of oil and meal, which is rich in fiber, protein, and fat. Its oil is arguably one of the richest source of polyunsaturated fatty acids, used in food and in the prevention of cardiovascular diseases [2,3].The use of natural catalysts offers a clean way to perform chemical process under mild reaction conditions with less or no usage of organic solvents, a high degree of selectivity due to the high chemo-, regio-and enantioselectivity of enzymes, while working under mild and environmental friendly conditions linked to the principles of green chemistry [4][5][6][7][8]. Thus, the biocatalysts can be an interesting alternative to prepare chiral alcohols and can also act as chiral auxiliaries in asymmetric synthesis of chiral molecules, and as a result the production of single enantiomers of molecules has become increasingly important in the food, cosmetic, and pharmaceutical industries, from the corresponding prochiral ketones [6,[9][10][11][12][13].…”

“…Thus, the biocatalysts can be an interesting alternative to prepare chiral alcohols and can also act as chiral auxiliaries in asymmetric synthesis of chiral molecules, and as a result the production of single enantiomers of molecules has become increasingly important in the food, cosmetic, and pharmaceutical industries, from the corresponding prochiral ketones [6,[9][10][11][12][13]. Therefore, researchers have strived to find solutions for the replacement of conventional chemical routes by application of enzymes.Reports in the literature describe the use of different plant species for biotransformation, with several advantages such as their disposal after use, their biodegrability, as well as their wide availability at low cost [6,[8][9][10][11][14][15][16][17].In particular, the potential source of enzymes from Brazilian northwestern plants and their use as biocatalysts in bioreduction reactions have been related [10,11,14,17,18]. In order to contribute to the study of vegetables as natural catalyst, this paper reports the use of whole plant cell of seeds of L. usitatissimum as a biocatalyst for the reduction reactions of aromatic ketones.…”

“…Thus, the biocatalysts can be an interesting alternative to prepare chiral alcohols and can also act as chiral auxiliaries in asymmetric synthesis of chiral molecules, and as a result the production of single enantiomers of molecules has become increasingly important in the food, cosmetic, and pharmaceutical industries, from the corresponding prochiral ketones [6,[9][10][11][12][13]. Therefore, researchers have strived to find solutions for the replacement of conventional chemical routes by application of enzymes.…”