Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly

Abstract

This is a repository copy of Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly.

Enabling protein-hosted organocatalytic transformations

“…Preparation of the modied ligands tends to be straightforward, involving simple synthetic techniques such as amide bond coupling and click chemistry. 35,39,[123][124][125][126] Hence, the supramolecular approach enables researchers to screen activity for a broad range of candidates within a short period of time. In addition, the protein hosts can still be engineered via rational design or laboratory evolution.…”

“…As a rule of thumb, the supramolecular catalytic complexes are built based on protein-ligand interactions that have dissociation constants (K D ) ranging from low mM to pM. [123][124][125]130 The ligand needs to possess a site for easy functionalisation while causing minimal effect on protein-ligand interaction. One such pair is the (strept)avidin and biotin, whose K D value is approximately 10 À14 M À1 .…”

Artificial imine reductases: developments and future directions

“…In devising the PBP artIRED, it was found a [Cp*Ir(pyridinesulfonamide)Cl] complex significantly outperformed the more commonly used aminoethylsulfonamide ligand for the reduction of 1a hence was the catalyst of choice in this design. 43 Furthermore, the length and attachment of the linker between the catalyst and the anchoring unit can greatly affect the performance of the catalyst. In one approach, a family of complexes with related structures, but variable linker lengths were incorporated into CAII.…”

Improved Access to Linear Tetrameric Hydroxamic Acids with Potential as Radiochemical Ligands for Zirconium(iv)-89 PET Imaging

“…The fundamental roles played by siderophores in nature and their potential applications in metal sequestration in the realms of health and the environment have inspired a large body of research. [3][4][5][6][7][8][9] One application of siderophores is as multidentate ligands for the coordination of radiometals for use in nuclear medicine. [10][11][12][13] The utility of hydroxamic acids to coordinate the radiometal zirconium(IV)-89 is the focus of the current work.…”