Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release

Gu, Haibin; Mu, Shengdong; Qiu, Guirong; Xiong, Liu; Zhang, Li; Yuan, Yanfei; Astruc, Didier

doi:10.1016/j.ccr.2018.03.013

Cited by 114 publications

(74 citation statements)

References 217 publications

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“…[1][2][3][4][5][6][7][8][9][10][11] Out of many methodologies to prepare metallopolymers,r ing-opening polymerization (ROP)o fs trained ferrocenophanes (FCPs) had been extensively applied in the past. [1][2][3][4][5][6][7][8][9][10][11] Out of many methodologies to prepare metallopolymers,r ing-opening polymerization (ROP)o fs trained ferrocenophanes (FCPs) had been extensively applied in the past.…”

Section: Introductionmentioning

confidence: 99%

Unique Bora[1]ferrocenophanes with Sterically Protected Boron: A Potential Gateway to Helical Polyferrocenes

2019

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Section: Introductionmentioning

confidence: 99%

Unique Bora[1]ferrocenophanes with Sterically Protected Boron: A Potential Gateway to Helical Polyferrocenes

2019

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“…[35,36] For example, Liu et al described a redox-controlled drug delivery system based on ferrocene (Fc)-containing amphiphilic block copolymers (PEG-b-PMAEFc) that were fabricated via atom transfer radical polymerization (ATRP) using a PEGbased macro-ATRP agent. [37][38][39][40][41][42] And notably, this redox process is attributed to the gain and loss of one electron, and the molecular structure of Fc group is not destroyed, which is a great benefit for the reversible self-assembly and disassembly of Fc-containing amphiphilic macromolecules. [37][38][39][40][41][42] And notably, this redox process is attributed to the gain and loss of one electron, and the molecular structure of Fc group is not destroyed, which is a great benefit for the reversible self-assembly and disassembly of Fc-containing amphiphilic macromolecules.…”

Section: Introductionmentioning

confidence: 99%

Ferrocenyl amphiphilic Janus dendrimers as redox‐responsive micellar carriers

Ling

et al. 2019

Applied Organom Chemis

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Amphiphilic Janus dendrimers have attracted increasing attention due to their asymmetric structures and various functional properties compared to the conventional symmetric macromolecules. Herein, a novel ferrocenyl-terminated amphiphilic Janus dendrimer containing nine hydrophilic triethylene glycol branches was synthesized by two synthetic routes, namely the typical chemo selective coupling method and the mixed modular approach. Chemical redox triggers, namely Fe 2 (SO 4 ) 3 as oxidant and ascorbic acid as reductant, could regulate the self-assembly behavior of the Janus dendrimer in water through the redox-switching between ferrocene and ferricinium cations, and the change of micelles formed were investigated and confirmed through scanning electron microscopy and dynamic light scattering. The cargo-loading property of the micelles self-assembled by the Janus dendrimer was further proved by the successful fabrication of Rhodamine B (RhB)-loaded micelles, and the oxidation-triggered release behavior of the encapsulated RhB could be mediated by changing the concentration of oxidants. This work provides an effective approach to prepare ferrocenyl-terminated amphiphilic Janus dendrimers and the self-assembled micelles might be used as a promising molecular carrier in areas such as drug delivery and catalysis.

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“…The unique electrochemical, physicochemical, magnetic, and optical properties of ferrocene (Fc)‐containing polymers have attracted widespread concerns in the fields of molecular battery, amperometric biosensors, sensors, nanopatterns, drug delivery, electrochromics, and catalysis . Particularly, Fc‐containing polymers could be used as reducing agents to prepare MNPs .…”

Section: Introductionmentioning

confidence: 99%

AuNPs composites of gelatin hydrogels crosslinked by ferrocene‐containing polymer as recyclable supported catalysts

Long

Song

Shi

et al. 2019

J of Applied Polymer Sci

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To fabricate a recyclable supported catalyst based on gold nanoparticles (AuNPs) and gelatin hydrogel (HG) composites, a ferrocene (Fc)-containing tetrablock copolymer [P(NCHO-b-NFc-b-NTEG-b-NCHO)] was used as both reducing and stabilizing agents for AuNPs and as a crosslinker for HG. First, the effects of Fc-containing polymers, including homopolymer PNFc and copolymer P(NCHO-b-NFc-b-NTEG-b-NCHO), and different solvent systems on the morphology and aggregation of AuNPs were examined by using ultraviolet-visible spectroscopy, transmission electron microscopy, and dynamic light scattering. Second, two strategies (blending and soaking) were applied to prepare different AuNPs/HG composites (AuNPs-HG), and their structure and properties were studied by using various techniques including scanning electron microscopy, X-ray diffraction, and thermogravimetry. Finally, the catalytic performance and reusability of AuNPs-HG-1 (via blending) and AuNPs-HG-2 (via soaking) were evaluated utilizing the model catalytic reduction of 4-nitrophenol to 4-aminophenol by NaBH 4 . Results indicated that P(NCHO-b-NFc-b-NTEG-b-NCHO) dissolved in N,Ndimethylformamide was the optimal reductant and stabilizer to prepare AuNPs. The in situ reduction of Au III ions to Au 0 particles was very essential for the fabrication of AuNPs-HG in terms of hydrogel pore size, Au 0 distribution and immobilization stability, and hydrogel thermal stability. Due to the stronger interactions among AuNPs, P(NCHO-b-NFc-b-NTEG-b-NCHO), and gelatin molecules in the blending strategy, AuNPs-HG-1 showed better mechanical stability and catalytic performance and more reusing cycles than AuNPs-HG-2. This work highlights the design and fabrication of robust recyclable supported AuNP catalyst by using eco-friendly Fccontaining HGs.

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Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release

Cited by 114 publications

References 217 publications

Unique Bora[1]ferrocenophanes with Sterically Protected Boron: A Potential Gateway to Helical Polyferrocenes

Unique Bora[1]ferrocenophanes with Sterically Protected Boron: A Potential Gateway to Helical Polyferrocenes

Ferrocenyl amphiphilic Janus dendrimers as redox‐responsive micellar carriers

AuNPs composites of gelatin hydrogels crosslinked by ferrocene‐containing polymer as recyclable supported catalysts

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