Redox signaling in acute pancreatitis

Pérez, Salvador; Pereda, Javier; Sabater, Luís; Sastre, Juan

doi:10.1016/j.redox.2015.01.014

Cited by 116 publications

(85 citation statements)

References 221 publications

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“…Acute pancreatitis is a localised inflammation of the pancreatic gland leads to local and systemic complications [33]. In this study, L-arg was used to induce experimental AP in rats, whereas its mechanism to induce pancreatitis is not fully clear.…”

Section: Discussionmentioning

confidence: 97%

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

Sadek

Khattab

2017

Folia Morphol

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Background: Acute pancreatitis (AP) is an inflammatory disease that has an incre- Materials and methods: Thirty-six adult male albino rats were used in this study. Animals were divided into four groups; Control group (Group A; n = 6), Mel group (Group B; n = 6), L-arg group (Group C; n = 12) receiving two doses of L-arg injection with 1 h interval in-between, and L-arg+Mel group (Group D; n = 12) receiving Mel 1 h after each L-arg injection. 24 h after the second L-arg injection, the serum levels of amylase (AM), lipase (LP), interleukin-6 (IL-6) and (Folia Morphol 2017; 76, 1: 66-73)

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Section: Discussionmentioning

confidence: 97%

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

Sadek

Khattab

2017

Folia Morphol

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“…When studies on TNF-α are examined, it is observed that anti-TNF-α treatment is effective on pancreatic cell healing 19 . In addition, many conducted studies have shown that an increase in IL-1β and IL-6 levels may be precursor markers of pancreatic damage and these levels were seen to decrease after treatment 5 . In this study, EA was seen to correct increased IL-1β, IL-6, and TNF-α levels seen during AP in the AP-EA group, and these results were confirmed by histopathological evaluations as well.…”

Section: Figure 1 -Hematoxylin-eosin (Hande) Staining (X200) Microscopmentioning

confidence: 99%

“…The mean incidence around the world is 40/100 2,3 . Many studies have shown that cytokines such as IL-1β, IL-6, and TNF-α 4,5 , which are secreted due to ductal obstruction and ductal injury as well as oxidative stress, are involved in the pathogenesis of AP 6,8 . Oxidative stress, through reactive oxygen species, can damage the membrane resulting in lipid peroxidation, and alter the cytosol dynamics leading to early activation of pancreatic digestive enzymes that initiate pancreatic damage.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis

et al. 2016

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PURPOSE:To investigate the therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis in rats. METHODS:Thirty-two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L-arginine administration, rats were sacrificed by cardiac puncture.Group 4 (EA)-(AP): 85mg/kg EA was administered orally after the L-arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF-α, IL-1β, IL-6, total oxidative status (TOS), total antioxidant capacity (TAC), amylase levels were determined in all groups. RESULTS:Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001). Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA). TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003). Group 3 (AP) showed significantly increased TNF-α, IL-1β and IL-6 serum levels as compared to Group 4 (AP+EA). Histopathological changes were supported our result. CONCLUSION:The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue.

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“…Reactive oxygen substances (ROS) may also contribute to the damage of pancreatic acinar cells. 4,[6][7][8][9][10] Previous studies have confirmed the participation of ROS at early stages of AP, regardless of the underlying cause. [11][12][13] The characteristics of the pancreatitis induced by cerulein (a decapeptide and cholecystokinin analogue) resemble the early phase of AP in humans.…”

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confidence: 99%

The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

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OBJECTIVE:The aim of this study was to evaluate the protective and therapeutic effects of quercetin on pancreatic injury in cerulein-induced acute pancreatitis. METHOD: Thirty-two rats were randomly divided into four groups, eight per group: (CT): untreated controls, (CER) treated with cerulein, 50 μg/kg body weight; (Q+CER) pre-treatment with quercetin, 100 mg/kg body weight, followed by cerulein, 50 μg/kg; (CER+Q) post-treatment, cerulein followed by quercetin, same doses. Cerulein was divided into four doses, given at 1-hour intervals by intraperitoneal injection. Quercetin was given either 1-hour before (in pre-treatment group) or 1-hour after (in post-treatment group) cerulein. Pancreatic malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), reduced and oxidized glutathione (GSH and GSSG, respectively) were measured. Histology of the pancreas was studied. RESULTS: (1) MDA, carbonyl, MPO, TNF-a and IL-6 levels were significantly higher in CER vs CT rats. (2) MDA, carbonyl, MPO and TNF-α decreased significantly in pre-treated rats vs. CER. (3) MDA, MPO, TNF-α, IL-6 were significantly lower in post-treated rats vs. CER. (4) The reduced vs. oxidized glutathione ratio (GSH/GSSG) of was significantly lower CER vs. CT rats. (5) Pre-and post-treatment with quercetin significantly increased this ratio. (6) Pancreatic histology showed that quercetin had no significant effect on the histological image of the pancreas CONCLUSION: These results suggest that quercetin can attenuate the severity of cerulein-induced acute pancreatitis by acting as an antioxidant and anti-inflammatory agent and combating oxidative stress. Further studies are needed to clearly explain its utility on acute pancreatitis.

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Redox signaling in acute pancreatitis

Cited by 116 publications

References 221 publications

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

Therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis

The effect of quercetin on cerulein-induced acute pancreatitis

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