Redox signaling and modulation in ageing

Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer’s Disease and the Assessment of the Protective Potential of D-Galactose

“…Further investigation is needed to clarify the exact mechanisms underlying these findings. Nrf2 stands out as a vital signaling pathway that governs the control of cellular antioxidant defense capacity, especially in response to nutrients and oxidative stress. − Given the reduced ability of STZ cells to react to a pro-oxidative environment by boosting their antioxidant mechanisms, it is imperative for future research to investigate whether the absence of this compensatory response in STZ cells could be linked to the dysregulation of Nrf2 and its associated pathways. In both groups, the reactivity of SOD2 activity was minimal, suggesting that its modulation was not a significant factor in the response to coincubation with oxidants and D-galactose.…”

“…In reality, however, AAPH is a free-radical-generating azo compound capable of initiating oxidation through various complementary mechanisms. On the other hand, H 2 O 2 is a stable, diffusible, nonradical oxidant that also plays essential roles in endogenous redox signaling. ,,− H 2 O 2 is a significant molecule involved in the regulation of redox and metabolic pathways through its interactions with multiple redox-sensitive proteins. ,,− Consequently, its production and spatiotemporal patterns are tightly controlled within cells, ,,− and it is probable that modeling the oxidative environment using H 2 O 2 resulted in distinct effects on these pathways in both CTR and STZ samples. This is evident, for example, in the differential expression of CAT and the responses to prooxidative conditions.…”

“…On the other hand, H 2 O 2 is a stable, diffusible, nonradical oxidant that also plays essential roles in endogenous redox signaling. 4 , 73 , 92 − 94 H 2 O 2 is a significant molecule involved in the regulation of redox and metabolic pathways through its interactions with multiple redox-sensitive proteins. 4 , 73 , 92 − 94 Consequently, its production and spatiotemporal patterns are tightly controlled within cells, 4 , 73 , 92 − 94 and it is probable that modeling the oxidative environment using H 2 O 2 resulted in distinct effects on these pathways in both CTR and STZ samples.…”

“… 4 , 73 , 92 − 94 H 2 O 2 is a significant molecule involved in the regulation of redox and metabolic pathways through its interactions with multiple redox-sensitive proteins. 4 , 73 , 92 − 94 Consequently, its production and spatiotemporal patterns are tightly controlled within cells, 4 , 73 , 92 − 94 and it is probable that modeling the oxidative environment using H 2 O 2 resulted in distinct effects on these pathways in both CTR and STZ samples. This is evident, for example, in the differential expression of CAT and the responses to prooxidative conditions.…”

Targeting mitochondria for ovarian aging: new insights into mechanisms and therapeutic potential

“…Free Radical Theory of Aging, introduced in 1956, proposes that the accumulated damage caused by free radicals, which are produced during normal metabolic processes, contributes to the aging process ( 21 ). ROS, including free radicals, are believed to induce oxidative damage, affecting cellular structures and molecules over time ( 22 ).…”