Redox-Sensitive Polymer/SPIO Nanocomplexes for Efficient Magnetofection and MR Imaging of Human Cancer Cells

Huang, Rih-Yang; Chiang, Pin-Hsin; Hsiao, Wei-Chen; Chuang, Ching-Hao; Chang, Chien‐Wen

doi:10.1021/acs.langmuir.5b01208

Cited by 43 publications

(25 citation statements)

References 34 publications

(48 reference statements)

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“…Dual/multi‐responsive delivery systems have the ability to simultaneously overcome various barriers during targeted delivery, including blood clearance, cellular uptake and intracellular release of the cargo. Among the designs of most multi‐responsive systems, the most commonly studied comprise a combination two different stimuli, such as pH/redox, pH/ROS, pH/ATP, pH/enzyme, pH/light, light/redox and redox/magnetic field . Those systems have some unique characteristics, including high cell uptake, low cytotoxicity and specific intracellular gene release, etc.…”

Section: Dynamic and Bioresponsive Processes Have Inspired Designs Inmentioning

confidence: 99%

Virus‐inspired and mimetic designs in non‐viral gene delivery

Luo

Liang

Jin

et al. 2019

The Journal of Gene Medicine

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Virus‐inspired mimics for nucleic acid transportation have attracted much attention in the past decade, especially the derivative microenvironment stimuli‐responsive designs. In the present mini‐review, the smart designs of gene carriers that overcome biological barriers and realize an efficient delivery are categorized with respect to the different “triggers” provided by tumor cells, including pH, redox potentials, ATP, enzymes and reactive oxygen species. Some dual/multi‐responsive gene vectors have also been introduced that show a more precise and efficient delivery in the complicated environment of human body. In addition, inspired by the special recognition mechanisms and components of viruses, improvements in the design of carriers relating to targeting/penetration properties, as well as chemical component evolution, are also addressed.

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Section: Dynamic and Bioresponsive Processes Have Inspired Designs Inmentioning

confidence: 99%

Virus‐inspired and mimetic designs in non‐viral gene delivery

Luo

Liang

Jin

et al. 2019

The Journal of Gene Medicine

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“…Several attempts, also including NPs, have been made to distribute anti-survivin siRNA in order to silence the BIRC5 gene [445,446,447]. For NP-based GTH applications for PCa, there are also quite few publications the last decade [141,448,449,450,451,452]. Guo et al investigated, for example, gene silencing using siRNA-based AuNPs for LNCaP cells, overexpressing PSMA.…”

Section: Multimodal Therapy Options For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

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Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

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“…The in vivo transfection efficiency was greatly increased under the influence of external magnetic field. This polymeric SPIONs demonstrated significant transgene expression on human prostate cancer cell lines and mouse glioma . Prijic et al used surface modified magnetic nanoparticles against murine mammary cancer.…”

Section: Strategies For Anticancer Therapymentioning

confidence: 99%

Tailoring of physicochemical properties of nanocarriers for effective anti‐cancer applications

Chakraborty

Dhakshinamurthy

Misra

2017

J Biomedical Materials Res

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Nanotechnology has emerged strongly as a viable option to overcome the challenge of early diagnosis and effective drug delivery, for cancer treatment. Emerging research articles have expounded the advantages of using a specific type of nanomaterial-based system called as "nanocarriers," for anti-cancer therapy. The nanocarrier system is used as a transport unit for targeted drug delivery of the therapeutic drug moiety. In order for the nanocarriers to be effective for anticancer therapy, their physicochemical parameter needs to be tuned so that bio-functionalisation can be achieved to (1) allow drugs being attached to the substrate and for their controlled release, (2) ensure the stability of the nanocarrier up to the point of delivery, and (3) clearance of the nanocarrier after the delivery. It is therefore envisaged that tailoring of the physicochemical properties of nanocarriers can greatly influence their reactivity and interaction in the biological milieu, and this is becoming an important parameter for increasing the efficacy of cancer therapy. This review emphasizes the importance of physicochemical properties of nanocarriers, and how they influence its usage as chemotherapeutic drug carriers. The goal of this review is to present a correlation between the physicochemical properties of the nanocarriers and its intended action, and how their design based on these properties can enhance their cancer combating abilities while minimizing damage to the healthy tissues. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2906-2928, 2017.

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Redox-Sensitive Polymer/SPIO Nanocomplexes for Efficient Magnetofection and MR Imaging of Human Cancer Cells

Cited by 43 publications

References 34 publications

Virus‐inspired and mimetic designs in non‐viral gene delivery

Virus‐inspired and mimetic designs in non‐viral gene delivery

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Tailoring of physicochemical properties of nanocarriers for effective anti‐cancer applications

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