Redox-Sensitive multifunctional hyaluronic acid-based nanomicelles with Fine-controlled anticancer drug release

Karimi‐Soflou, Reza; Karkhaneh, Akbar

doi:10.1016/j.ijpharm.2022.122402

Cited by 10 publications

(3 citation statements)

References 48 publications

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“…The glycosidic protons of sugar units of HA were observed at chemical shifts between 3.0 and 4.1 ppm along with N ‐acetyl (‐NHCOCH 3 ) group's methyl protons at 1.9 ppm for all samples. [ 10c,18 ] Two additional peaks were observed on NMR spectrums of sphingosine conjugated samples (HA‐Sph) that indicated methylene (‐CH 2 ‐) protons (1165 ppm) and terminal methyl (‐CH 3 ) protons (0.95 ppm) of sphingosine molecules. [ 10c,13b ] These additional peaks confirmed the successful grafting of sphingosines to HA chain.…”

Section: Resultsmentioning

confidence: 99%

Hyaluronan‐Sphingosine Polymersomes for Treatment of Ocular Neovascularization: Synthesis and Evaluation

Yetisgin,

Durak,

Kutlu

et al. 2024

Macromolecular Bioscience

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Ocular neovascularization is a hallmark of several sight‐threatening diseases, including diabetic retinopathy and age‐related macular degeneration. Currently, available treatments are limited and often associated with side effects. Therefore, we present a novel approach to ocular neovascularization treatment through utilization of polymersomes from self‐assembled sphingosine‐grafted hyaluronic acid (HA‐Sph) amphiphilic polymers. The polymersomes are generated in spherical morphologies and sizes between 97.95 nm – 161.9 nm with homogenous size distributions. Our experiments revealed that HA‐Sph polymersomes, with concentrations ≥150 μg/mL, significantly inhibit the proliferation of HUVECs, while concurrently promoting the proliferation of retinal pigment epithelial cells. The polymersomes demonstrated gradual disintegration in vitro, leading to a sustained release of sphingosine, which prolonged the inhibition of HUVEC proliferation (from 87.5% at 24 h to 35.2% viability at 96 h). The efficacy of HA‐Sph polymersomes in inhibiting angiogenesis was confirmed through tube formation assay, revealing a substantial reduction in total tube length compared to the control group. Our findings also validated the ocular penetration capability of polymersomes through an ex vivo whole porcine eye ocular penetration study, indicating their suitability for topical administration. Potentially, HA‐Sph polymersomes can be harnessed to develop intricate drug delivery systems that protect the retina and effectively treat ocular diseases.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Hyaluronan‐Sphingosine Polymersomes for Treatment of Ocular Neovascularization: Synthesis and Evaluation

Yetisgin,

Durak,

Kutlu

et al. 2024

Macromolecular Bioscience

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“…314 Similarly, Karimi-Soflou et al proposed self-assembled micelles derived from hyaluronic acid-palmitoyl (HA-ss-PA) amphiphilic derivatives, aiming to precisely target Dox to breast cancer cells overexpressing high HA receptor. 315 The results indicated that…”

Section: Redox-responsive Npsmentioning

confidence: 98%

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Xing

Zhou

et al. 2023

J. Mater. Chem. B

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“…Nonetheless, they are burdened with lethal side effects including the rapid emergence of resistant cells and toxic effects, which call for the development of a new approach [4,5]. An example of a classic chemotherapy drug that is frequently employed in the treatment of breast cancer and lung cancer is Doxorubicin HCl (DOX.HCl) [6][7][8]. However, DOX.HCl does not possess the ability to specifically target tumor tissues and can still result in significant adverse effects on healthy tissues and organs [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

Ma,

Li,

Zhang

et al. 2024

Marine Drugs

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The present study focused on the design and preparation of acid-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for a controlled, slow-release of Doxorubicin HCl (DOX.HCl). The BIMIXHAC was crosslinked with sodium tripolyphosphate (TPP) using the ion crosslinking method. The method resulted in nanogels with low polydispersity index, small particle size, and positive zeta potential values, indicating the good stability of the nanogels. Compared to hydroxypropyl trimethyl ammonium chloride chitosan-Doxorubicin HCl-sodium tripolyphosphate (HACC-D-TPP) nanogel, the benzimidazole-chitosan quaternary ammonium salt-Doxorubicin HCl-sodium tripolyphosphate (BIMIXHAC-D-TPP) nanogel show higher drug encapsulation efficiency and loading capacity (BIMIXHAC-D-TPP 93.17 ± 0.27% and 31.17 ± 0.09%), with acid-responsive release profiles and accelerated release in vitro. The hydroxypropyl trimethyl ammonium chloride chitosan-sodium tripolyphosphate (HACC-TPP), and benzimidazole-chitosan quaternary ammonium salt-sodium tripolyphosphate (BIMIXHAC-TPP) nanogels demonstrated favorable antioxidant capability. The assay of cell viability, measured by the MTT assay, revealed that nanogels led to a significant reduction in the cell viability of two cancer cells: the human lung adenocarcinoma epithelial cell line (A549) and the human breast cancer cell line (MCF-7). Furthermore, the BIMIXHAC-D-TPP nanogel was 2.96 times less toxic than DOX.HCl to the mouse fibroblast cell line (L929). It was indicated that the BIMIXHAC-based nanogel with enhanced antioxidant and antitumor activities and acidic-responsive release could serve as a potential nanocarrier.

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Redox-Sensitive multifunctional hyaluronic acid-based nanomicelles with Fine-controlled anticancer drug release

Cited by 10 publications

References 48 publications

Hyaluronan‐Sphingosine Polymersomes for Treatment of Ocular Neovascularization: Synthesis and Evaluation

Hyaluronan‐Sphingosine Polymersomes for Treatment of Ocular Neovascularization: Synthesis and Evaluation

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

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