Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Zhu, Zhehong; Wu, Manran; Sun, Juan; Huangfu, Zhengyuan; Yin, Lei; Yong, Wei‐Peng; Sun, Jing; Wang, Guanglin; Meng, Fenghua; Zhong, Zhiyuan

doi:10.1080/10717544.2021.1995080

Cited by 11 publications

(13 citation statements)

References 54 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the antimetabolite methotrexate was loaded into the hydrophobic core of the micelles to enhance the cytotoxic effect of radionuclide therapy. The results confirmed that 111 In was effectively accumulated in tumor tissues with high HER2 expression level, and the nuclear radioactivity of the block copolymer micelles was two-to fivefold higher than those without NLS modification, providing a new type of targeted ligands for polymeric micelles loaded with a radioisotope.…”

Section: Radiosensitizers Based On Active Targeting Polymeric Micellessupporting

confidence: 58%

“…For instance, Zhong and coworkers developed a kind of redox‐sensitive iodinated polymersomes (RIP) with tri‐block polymer encapsulating histone deacetylase inhibitors (SAHA) within their hydrophilic lumen. [ 111 ] The obtain polymersomes (RIP‐SAHA) were dually functional, which could not only enhance the radiation absorption due to iodine they contained, but also expose DNA directly to radiation by reducing the interaction between DNA and histone. With the disulfide bond as a crosslinker in the hydrophobic block, the polymersomes were responsive to the highly expressed GSH in tumor tissues.…”

Section: Polymersomes and Polymer‐functionalized Liposomesmentioning

confidence: 99%

“…[41] Hence, with targeting group conjugated to the hydrophilic block, polymeric micelles can be developed for targeted drug delivery. [42][43][44] Early in 2012, a kind of multifunctional block copolymer micelles labeled with the radioisotope indium-111 ( 111 In) was reported for in situ radiation treatment of cancer. [45] By conjugating HER2-specific antibodies and nuclear localization signal (NLS) peptides on the surface, the cell uptake and intracellular distribution of the block copolymer micelles were remarkably improved in the treatment of HER2overexpressing breast cancer cells.…”

Section: Radiosensitizers Based On Active Targeting Polymeric Micellesmentioning

confidence: 99%

See 2 more Smart Citations

Nanomaterials Based on Functional Polymers for Sensitizing Cancer Radiotherapy

Lin

Yin

Liu

et al. 2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Despite being the mainstay treatment for many types of cancer in clinic, radiotherapy is undertaking great challenges in overcoming a series of limitations. Radiosensitizers are promising agents capable of depositing irradiation energy and generating free radicals to enhance the radiosensitivity of tumor cells. Combining radiosensitizers with functional polymer-based nanomaterials holds great potential to improve biodistribution, circulation time, and stability in vivo. The derived polymeric nano-radiosensitizers can significantly improve the efficiency of tumor targeting and radiotherapy, and reduce the side effect to healthy tissues. In this review, an overview of functional polymer-based nanomaterials for radiosensitization in recent years is provided. Particular emphases are given to the action mechanisms, drug loading methods, targeting efficiencies, the impact on therapeutic effects, and biocompatibility of various radiosensitizing polymers, which are classified as polymeric micelles, dendrimers, polymeric nanospheres, nanoscale coordination polymers, polymersomes, and nanogels. The challenges and outlooks of polymeric nano-radiosensitizers are also discussed.

show abstract

Section: Radiosensitizers Based On Active Targeting Polymeric Micellessupporting

confidence: 58%

Section: Polymersomes and Polymer‐functionalized Liposomesmentioning

confidence: 99%

Section: Radiosensitizers Based On Active Targeting Polymeric Micellesmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials Based on Functional Polymers for Sensitizing Cancer Radiotherapy

Lin

Yin

Liu

et al. 2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…125 I-radiolabelled SN-38 ( 125 I-SN-38) was prepared by the iodogen method. 33 SN-38 was dissolved in DMSO and added to an iodogen tube with NaI ( 125 I) (1 mCi) for 30 min. The radiolabelling efficiency was determined by thin layer chromatography (TLC) using HCl (pH=3) solution as a mobile phase.…”

Section: Methodsmentioning

confidence: 99%

Folate Decorated Multifunctional Biodegradable Nanoparticles for Gastric Carcinoma Active Targeting Theranostics

Zhang¹,

Yan²,

Wei³

et al. 2022

IJN

View full text Add to dashboard Cite

“…Surprisingly, there were 17.3‐folds increased circulation and 237.7‐folds accumulation at the cancer microenvironment reported for this vesicular structure when compared to free SAHA. [ 163 ] Therefore, in a nutshell it could be said that the vesicular formulations can be a prospective platform to deliver epigenetic drugs with improved cancer therapy in a safer way.…”

Section: Progress Of Nanocarrier‐based Research Toward Improved Deliv...mentioning

confidence: 99%

Current Strategies in Breast Cancer Therapy: Role of Epigenetics and Nanomedicine

Sengupta

Choudhury

Dutta

et al. 2022

Part & Part Syst Charact

View full text Add to dashboard Cite

Breast cancer (BC), the most common cancer in women, is incurable due to metastatic spread to distant organs. The existence of epigenetic dysregulation has been shown to contribute to the progression and even metastasize through the transition from epithelial to mesenchymal. Behind failure strategies of conventional treatments, fruitful outcomes of epigenetic drugs have provided the hope of solid tumor management where the reversal of acquired resistance of the cancer cells is possible by epigenome regulation. Several agents have been identified to target epigenetic regulators in the cancer cells exhibiting remarkable potential against solid tumors, including BC. However, unnecessary systemic exposure, solubility issues, and unsuitability for diseased conditions using conventional delivery systems limit their use as cancer therapeutics. The progression of nanotechnology in pharmaceutical delivery has revolutionized cancer therapy, where specific, targeted and efficient delivery of epigenetic agents for alteration of cancerous conditions are ensured. In this review, a focus is made on epigenetic alteration in BC condition with the deliverable potential of the nanocarriers toward the breast tumor microenvironment for proper management. The significance of targeting and controlled release of therapeutics in the improved targeting of cancer cells is highlighted.

show abstract

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Cited by 11 publications

References 54 publications

Nanomaterials Based on Functional Polymers for Sensitizing Cancer Radiotherapy

Nanomaterials Based on Functional Polymers for Sensitizing Cancer Radiotherapy

Folate Decorated Multifunctional Biodegradable Nanoparticles for Gastric Carcinoma Active Targeting Theranostics

Current Strategies in Breast Cancer Therapy: Role of Epigenetics and Nanomedicine

Contact Info

Product

Resources

About