Redox responsive xylan-SS-curcumin prodrug nanoparticles for dual drug delivery in cancer therapy

Sauraj, .; Kumar, Vinay; Kumar, Bijender; Priyadarshi, Ruchir; Deeba, Farha; Kulshreshtha, Anurag; Kumar, Anuj; Agrawal, Garima; Gopinath, P.; Negi, Yuvraj Singh

doi:10.1016/j.msec.2019.110356

Cited by 68 publications

(29 citation statements)

References 47 publications

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“…The most common methods for synthesizing the XNPs are precipitation and dialysis methods. In the precipitation method, xylan solution is direct introduced into another certain solution to form the XNPs, such as acid solution [ 33 ], ethanol [ 16 ], ethyl ether [ 36 , 37 ], or water [ 38 ]. The XNPs from the precipitation method tended to have an irregular shape [ 33 , 39 ], while the roughly uniform spherical XNPs could be formed by the dialysis method [ 34 , 35 , 38 ].…”

Section: Xylan Nanoparticles (Xnps)mentioning

confidence: 99%

“…Moreover, additional steps are necessary to functionalize the XNPs or the drugs in drug delivery application so that the special linkages can be formed. Previous studies have carried out the XNPs or drug functionalizations using several compounds, such as formic acid [ 33 ], acetic acid [ 16 ], succinic anhydride [ 34 ], stearic acid [ 35 , 36 ], 3,3′-dithiodipropionic acid [ 37 ], N - N′ -carbonyl diimidazole [ 35 , 38 ], and cholesteryl [ 40 ].…”

Section: Xylan Nanoparticles (Xnps)mentioning

confidence: 99%

“…The high enough release at pH 5.0 gives an advantage for the XNPs application in targeting tumor and cancer cells, especially in the colon, where the common pH environment of tumor and cancer cells is about 5.0 [ 34 ]. Another functionalization of prodrug XNPs using 3-3′-dithiodipropionic acid has also been carried out to further investigate the targeting ability of functionalized-prodrug XNPs into cancer cells [ 37 ]. This functionalization formed the disulfide linkages in the structure of prodrug XNPs to trigger the redox-responsive degradation in cancer cells.…”

Section: Xylan Nanoparticles (Xnps)mentioning

confidence: 99%

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A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

2021

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Due to their biocompatibility, biodegradability, and non-toxicity, lignocellulosic-derived nanoparticles are very potential materials for drug carriers in drug delivery applications. There are three main lignocellulosic-derived nanoparticles discussed in this review. First, lignin nanoparticles (LNPs) are an amphiphilic nanoparticle which has versatile interactions toward hydrophilic or hydrophobic drugs. The synthesis methods of LNPs play an important role in this amphiphilic characteristic. Second, xylan nanoparticles (XNPs) are a hemicellulose-derived nanoparticle, where additional pretreatment is needed to obtain a high purity xylan before the synthesis of XNPs. This process is quite long and challenging, but XNPs have a lot of potential as a drug carrier due to their stronger interactions with various drugs. Third, cellulose nanocrystals (CNCs) are a widely exploited nanoparticle, especially in drug delivery applications. CNCs have low cytotoxicity, therefore they are suitable for use as a drug carrier. The research possibilities for these three nanoparticles are still wide and there is potential in drug delivery applications, especially for enhancing their characteristics with further surface modifications adjusted to the drugs.

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Section: Xylan Nanoparticles (Xnps)mentioning

confidence: 99%

Section: Xylan Nanoparticles (Xnps)mentioning

confidence: 99%

Section: Xylan Nanoparticles (Xnps)mentioning

confidence: 99%

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A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

2021

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“…The incorporation of disulfide bonds in the middle/side chain of ABC or in a cross-linker provide redox responsiveness to SAN. Tumor-relevant GSH concentration cleavages these bonds, inducing nanocarrier disassembly and cargo release into cancer cells (Wen et al, 2011;Thambi et al, 2012;Hu et al, 2013;Jia et al, 2014;Li et al, 2014;Sun et al, 2014;Wen and Li, 2014;Che and van Hest, 2016;Thambi et al, 2016;Zou et al, 2016;Hu et al, 2017;Zhao et al, 2017;Bej et al, 2018;Qin et al, 2018;García, 2019b;Kumar et al, 2020;Wei Y. et al, 2020;Zhong et al, 2020).…”

Section: Enzyme-responsive Nanocarriersmentioning

confidence: 99%

Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

et al. 2020

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Cancer is one of the most common life-threatening illness and it is the world’s second largest cause of death. Chemotherapeutic anticancer drugs have many disadvantages, which led to the need to develop novel strategies to overcome these shortcomings. Moreover, tumors are heterogenous in nature and there are various biological barriers that assist in treatment reisistance. In this sense, nanotechnology has provided new strategies for delivery of anticancer therapeutics. Recently, delivery platforms for overcoming biological barriers raised by tumor cells and tumor-bearing hosts have been reported. Among them, amphiphilic block copolymers (ABC)-based self-assembled nanocarriers have attracted researchers worldwide owing to their unique properties. In this work, we addressed different biological barriers for effective cancer treatment along with several strategies to overcome them by using ABC‐based self-assembled nanostructures, with special emphasis in those that have the ability to act as responsive nanocarriers to internal or external environmental clues to trigger release of the payload. These nanocarriers have shown promising properties to revolutionize cancer treatment and diagnosis, but there are still challenges for their successful translation to clinical applications.

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“…In comparison, an accelerated release of DOX was activated in the presence of 10 mM GSH, in which over 60% and 80% of DOX was released from GAL-micelles at both pH 7.4 and 5.0, respectively. The reductive response triggered a rapid drug release which is due to the cleavage of disulfide bonds at the surface of the core [33], leading to shell shedding and micelle aggregating, followed by fast drug efflux during the reassembly of deprotected micelles [34].…”

Section: In Vitro Drugmentioning

confidence: 99%

Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells

Zhai

Zhou

et al. 2020

Journal of Nanomaterials

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Nanocarriers with integrated advantage, such as excellent stealth property, active targeting function, and rapid intracellular drug release, are significant for cancer treatment. Herein, a biodegradable zwitterionic triblock copolymer containing disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCB-SS-PCL-SS-PCB) was first synthesized and then partly modified with galactosamine (GAL) for constructing polymeric micelle drug carrier with multifunctionality. Polymeric micelles showed ultralow protein absorption in serum and obvious reduction-responsiveness in the presence of glutathione, provided by the zwitterionic polymer shell and the disulfide bond, respectively. Furthermore, active targeting of the carrier to hepatic carcinoma cells was achieved via GAL ligands on PCB shells due to their specific binding to asialoglycoprotein receptors on the cell surface. As expected, in vivo competition studies demonstrated that doxorubicin- (DOX-) loaded GAL-modified micelles have better anticancer effect in hepatic tumor-bearing mice than free DOX and nontargetable micelles. As a result, this novel multifunctional carrier provides a valuable strategy to design promising anticancer drug delivery systems for liver cancer treatment.

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Redox responsive xylan-SS-curcumin prodrug nanoparticles for dual drug delivery in cancer therapy

Cited by 68 publications

References 47 publications

A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells

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