Redox‐Responsive Nanocomposites Composed of Graphene Oxide and Chlorin e6 for Photodynamic Treatment of Cholangiocarcinoma

Kim, Dong Jun; Kim, Jungsoo; Lee, Hye Lim; Lee, Sangeun; Choi, Jung Sik; Kim, Su Jin; Jeong, Young‐Il; Kang, Dae Hwan

doi:10.1002/bkcs.11552

Cited by 10 publications

(12 citation statements)

References 35 publications

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“…The animals treated by the nanocomposite had a great accumulation of Ce6 in the tumor while the liver of other groups exhibited the highest uptake of it. 87 In a more recent study, gefitinib (Gef) as a drug for lung cancer was linked to HA functionalized GO nanosheets. The NGO-SS-HA-Gef nanocarrier showed significant responsiveness to the high level of GSH in A549 lung cancer cells due to the disulfide linkage.…”

Section: Redox-triggered Drug Release Of Graphenementioning

confidence: 99%

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<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

150

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Graphene, a wonder material, has made far-reaching developments in many different fields such as materials science, electronics, condensed physics, quantum physics, energy systems, etc. Since its discovery in 2004, extensive studies have been done for understanding its physical and chemical properties. Owing to its unique characteristics, it has rapidly became a potential candidate for nano-bio researchers to explore its usage in biomedical applications. In the last decade, remarkable efforts have been devoted to investigating the biomedical utilization of graphene and graphene-based materials, especially in smart drug and gene delivery as well as cancer therapy. Inspired by a great number of successful graphene-based materials integrations into the biomedical area, here we summarize the most recent developments made about graphene applications in biomedicine. In this paper, we review the up-to-date advances of graphene-based materials in drug delivery applications, specifically targeted drug/ gene delivery, delivery of antitumor drugs, controlled and stimuli-responsive drug release, photodynamic therapy applications and optical imaging and theranostics, as well as investigating the future trends and succeeding challenges in this topic to provide an outlook for future researches.

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Section: Redox-triggered Drug Release Of Graphenementioning

confidence: 99%

“…The animals treated by the nanocomposite had a great accumulation of Ce6 in the tumor while the liver of other groups exhibited the highest uptake of it. 87 …”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

150

View full text Add to dashboard Cite

show abstract

“…In 2018, Kim and collaborators described the synthesis of graphene oxide conjugated with chlorin e6 and methoxy poly(ethylene glycol) [ 119 ] ( Table 5 , entry 9). This nanomaterial was evaluated in a cellosaurus cell line using different concentrations (0–2.5 µg/mL), a light dose of 2.0 J/cm 2 , and 24 h of incubation, resulting in a cell viability of 10%.…”

Section: An Update On Chlorin-based Photosensitizers Immobilized Omentioning

confidence: 99%

Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy

Dias

Mfouo-Tynga

2020

Biomimetics

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Chlorophylls, which are chlorin-type photosensitizers, are known as the key building blocks of nature and are fundamental for solar energy metabolism during the photosynthesis process. In this regard, the utilization of bioinspired chlorin analogs as photosensitizers for photodynamic therapy constitutes an evolutionary topic of research. Moreover, carbon nanomaterials have been widely applied in photodynamic therapy protocols due to their optical characteristics, good biocompatibility, and tunable systematic toxicity. Herein, we review the literature related to the applications of chlorin-based photosensitizers that were functionalized onto carbon nanomaterials for photodynamic and photothermal therapies against cancer. Rather than a comprehensive review, we intended to highlight the most important and illustrative examples over the last 10 years.

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“…The SN38-PEG-GO was water soluble and stable in phosphate buffer saline and mouse serum and showed enhanced cell killing ability compared with a water-soluble drug CPT-11. This pioneer study has stimulated the reach on the delivery of various drugs, e.g., doxorubicin hydrochloride (DOX) [74][75][76][77][78], chlorin e6 (Ce6) [79,80], camptothecin (CPT) [81,82], methotrexate (MTX) [83][84][85], and ibuprofen [86]. As the most effective drug for cancer treatment, DOX is widely investigated.…”

Section: Graphenementioning

confidence: 99%

Functionalization of Carbon Nanomaterials for Biomedical Applications

Liu

Speranza

2019

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Over the past decade, carbon nanostructures (CNSs) have been widely used in a variety of biomedical applications. Examples are the use of CNSs for drug and protein delivery or in tools to locally dispense nucleic acids to fight tumor affections. CNSs were successfully utilized in diagnostics and in noninvasive and highly sensitive imaging devices thanks to their optical properties in the near infrared region. However, biomedical applications require a complete biocompatibility to avoid adverse reactions of the immune system and CNSs potentials for biodegradability. Water is one of the main constituents of the living matter. Unfortunately, one of the disadvantages of CNSs is their poor solubility. Surface functionalization of CNSs is commonly utilized as an efficient solution to both tune the surface wettability of CNSs and impart biocompatible properties. Grafting functional groups onto the CNSs surface consists in bonding the desired chemical species on the carbon nanoparticles via wet or dry processes leading to the formation of a stable interaction. This latter may be of different nature as the van Der Waals, the electrostatic or the covalent, the π-π interaction, the hydrogen bond etc. depending on the process and on the functional molecule at play. Grafting is utilized for multiple purposes including bonding mimetic agents such as polyethylene glycol, drug/protein adsorption, attaching nanostructures to increase the CNSs opacity to selected wavelengths or provide magnetic properties. This makes the CNSs a very versatile tool for a broad selection of applications as medicinal biochips, new high-performance platforms for magnetic resonance (MR), photothermal therapy, molecular imaging, tissue engineering, and neuroscience. The scope of this work is to highlight up-to-date using of the functionalized carbon materials such as graphene, carbon fibers, carbon nanotubes, fullerene and nanodiamonds in biomedical applications.

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Redox‐Responsive Nanocomposites Composed of Graphene Oxide and Chlorin e6 for Photodynamic Treatment of Cholangiocarcinoma

Cited by 10 publications

References 35 publications

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy

Functionalization of Carbon Nanomaterials for Biomedical Applications

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