Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Xie, Yuqing; Arik, Hacer; Wei, Lixia; Zheng, Yiran; Suh, Heikyung; Irvine, Darrell J.; Tang, Li

doi:10.1039/c8bm01556b

Cited by 67 publications

(42 citation statements)

References 34 publications

(45 reference statements)

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“…[ 25 ] Covalent conjugation has been investigated as a better alternative to noncovalent binding, and has found application in reducing the immune response after transplants in vivo, [ 45–47 ] as well as in cancer therapy by directly targeting T cells and boosting the immune response toward tumors. [ 94–96 ] However, the lack of selectivity of covalent approaches that use functional groups already present at the plasma membrane, such as amines and thiols, limits their applications in targeted cell therapies and increases their side effects. On the other hand, bio‐orthogonal chemistries offer unique and highly biocompatible routes to explore mammalian cell surface engineering.…”

Section: Discussionmentioning

confidence: 99%

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Engineering the Mammalian Cell Surface with Synthetic Polymers: Strategies and Applications

Arno

2020

Macromol. Rapid Commun.

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Manipulating the surface of living cells represents a powerful tool by which to control cell behavior and provides a unique strategy to modulate cellular function and cell–cell interactions. Recent progress in this area has seen the development of robust and elegant approaches to selectively decorate the cell surface, leading to unprecedented advances in cellular manipulation and cell‐based therapies. Despite some impressive in vitro results, several obstacles remain to the broader application of some of these strategies, including their limited translation in vivo. In this review, the leading techniques used to introduce polymers at the plasma membrane of mammalian cells are discussed, focusing on strategies that generate a stable and homogeneous distribution of polymeric chains at the cell surface. Application of these strategies to control cell behavior and deliver cell‐based therapies to targeted tissues are highlighted.

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Section: Discussionmentioning

confidence: 99%

“…[ 95 ] This approach was then extended to the delivery of IL‐2 in vivo, improving the efficacy of this therapy against melanoma metastases. [ 96 ]…”

Section: Targeting Polymeric Nanoparticles At the Cell Surfacementioning

confidence: 99%

Engineering the Mammalian Cell Surface with Synthetic Polymers: Strategies and Applications

Arno

2020

Macromol. Rapid Commun.

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“…In order to reduce the severity of adverse effects, Xie Y.Q. et al (2019) developed a complex delivery system, binding redox-responsive IL-2/Fc nanogels to the surface of adoptively transferred T cells [34]. Interestingly, the cytokine nanogels are able to selectively release IL-2 in response to the activation of T cell receptors after antigen recognition in tumors [34].…”

Section: High-dose Interleukin-2 (Il-2)mentioning

confidence: 99%

“…et al (2019) developed a complex delivery system, binding redox-responsive IL-2/Fc nanogels to the surface of adoptively transferred T cells [34]. Interestingly, the cytokine nanogels are able to selectively release IL-2 in response to the activation of T cell receptors after antigen recognition in tumors [34]. In a melanoma mouse model the delivery system showed improved efficiency, without obvious toxicity [34].…”

Section: High-dose Interleukin-2 (Il-2)mentioning

confidence: 99%

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Nanosystems for Improved Targeted Therapies in Melanoma

Beiu

Giurcăneanu

Grumezescu

et al. 2020

JCM

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Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative targeted therapies for melanoma has multiple benefits and could significantly improve the outcome of melanoma patients. In this paper, we review the most recent progress in the field of targeted therapies, emphasizing the impact of nanoscale materials on the targeting and controlled release of anti-tumor drugs. The applications of nanomedicine in the management of melanoma are extensive and refer to sentinel lymph node mapping, chemotherapy, and RNA interference; each of these applications harboring the potential to develop efficient and personalized diagnostic techniques and therapies. Further research, especially in clinical trials, is needed to establish whether fighting melanoma on the nanoscale level represents the key to reaching a critical inflection point in mankind’s battle with metastatic melanoma.

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Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Ayoubi‐Joshaghani

Seidi

Azizi

et al. 2020

Adv Funct Materials

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Novel advanced hydrogels can provide a versatile platform for controlled delivery and release of various cargos, with a myriad of biomedical applications. These gel-based nanostructures possess good biocompatibility, biodegradability, flexibility, multifunctionality, can respond to internal or external stimuli, and can adapt to their surrounding environment. This new generation of hydrogels is not only capable of serving as targeted drug delivery vehicles, but they can also perform a variety of tasks within living cells and organisms. In this review, advanced hydrogels are classified as static, dynamic, multistage, or bioinspired. They can be used as cell-free gene expression platforms for gene therapy. Administration of nanogel-based sprays can act as an immunovaccine priming macrophages toward the M1 phenotype to avoid cancer recurrence following surgery. Nanogels can also serve as a dual biosensing and capture platform for liquid biopsies, and can recognize and remove circulating cancer cells from the blood of cancer patients.

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Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Abstract: Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment.

Cited by 67 publications

References 34 publications

Engineering the Mammalian Cell Surface with Synthetic Polymers: Strategies and Applications

Engineering the Mammalian Cell Surface with Synthetic Polymers: Strategies and Applications

Nanosystems for Improved Targeted Therapies in Melanoma

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

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