Biochemical Pharmacology volume 82, issue 10, P1490-1499 2011 DOI: 10.1016/j.bcp.2011.07.092 View full text
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G. Pennisi, C. Cornelius, M.M. Cavallaro, A. Trovato Salinaro, M.T. Cambria, M. Pennisi, R. Bella, P. Milone, B. Ventimiglia, M.R. Migliore, L. Di Renzo, A. De Lorenzo, V. Calabrese

Abstract: Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease with characteristic foci of inflammatory demyelination in the brain, spinal cord, and optic nerves. Recent studies have demonstrated not only that axonal damage and neuronal loss are significant pathologic components of MS, but that this neuronal damage is thought to cause the permanent neurologic disability often seen in MS patients. Emerging finding suggests that altered redox homeostasis and increased oxidative stress, primarily imp…

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